L-Glutathione
- Product Name
- L-Glutathione
- CAS No.
- 27025-41-8
- Chemical Name
- L-Glutathione
- Synonyms
- GSSG;L-GLUTATHIONE OXIDIZED;GLUTATHIONE DISULFIDE;Oxiglutatione;oxidizedglutathione;L-GLUTATHIONE OXIDISED;GSSC;NOV-002;Glutathiol;oxigluthione
- CBNumber
- CB1200803
- Molecular Formula
- C20H32N6O12S2
- Formula Weight
- 612.63
- MOL File
- 27025-41-8.mol
L-Glutathione Property
- Melting point:
- 178 °C (dec.)(lit.)
- alpha
- -99 º (c=4, water)
- Density
- 1.3688 (rough estimate)
- refractive index
- -105 ° (C=2, H2O)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble
- form
- powder
- pka
- 2.12, 3.59, 8.75, 9.65(at 25℃)
- color
- White to off-white
- optical activity
- -111.016 (H2O)
- Water Solubility
- soluble
- Merck
- 13,4488
- BRN
- 1718700
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- YPZRWBKMTBYPTK-USZNOCQGSA-N
- CAS DataBase Reference
- 27025-41-8(CAS DataBase Reference)
- EPA Substance Registry System
- Oxiglutatione (27025-41-8)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25-36/37/39-27-37/39
- WGK Germany
- 2
- RTECS
- MC0556500
- HS Code
- 29309090
- Toxicity
- mouse,LD50,intravenous,> 2gm/kg (2000mg/kg),Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- G2299
- Product name
- L-Glutathione oxidized
- Purity
- PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production.
- Packaging
- 100g
- Price
- $1586
- Updated
- 2024/03/01
- Product number
- G2299
- Product name
- L-Glutathione oxidized
- Purity
- PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production.
- Packaging
- 1kg
- Price
- $10456
- Updated
- 2024/03/01
- Product number
- 3542
- Product name
- Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem
- Purity
- Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys
- Packaging
- 1g
- Price
- $96.7
- Updated
- 2024/03/01
- Product number
- 3542
- Product name
- Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem
- Purity
- Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys
- Packaging
- 5G
- Price
- $265
- Updated
- 2024/03/01
- Product number
- G0073
- Product name
- Glutathione oxidized form
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $64
- Updated
- 2024/03/01
L-Glutathione Chemical Properties,Usage,Production
Description
L-Glutathione oxidized(GSSG) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of it. It can be used for the research of sickle cells and erythrocytes. The ratio of glutathione (GSH) to oxidised glutathione (GSSG) is a key indicator of cellular oxidative stress. It can be used in the clinical diagnosis and treatment of leukaemia by detecting the level of cellular GSH/GSSG in acute myeloid leukaemia (AML), which is characterised by oxidative stress leading to abnormally low levels of oxidised glutathione, with real-time, dynamic and highly sensitive characteristics[1].
Uses
L-Glutathione is used as a Acts as hydrogen acceptor in enzymatic determination of NADP and NADPH, it is used to reduced back to glutathione (GSH) via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress, L-Glutathione formation is used to study the polymorphism in glutathione conjugation ac tivity of human erythrocytes towards ethylene dibromide.
Application
L-Glutathione (GSH) has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads. It has been used to prepare a standard curve for GSH analyses. May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.
Definition
ChEBI: Glutathione disulfide is an organic disulfide and a glutathione derivative. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a glutathione disulfide(2-).
Biochem/physiol Actions
L-Glutathione, oxidized is frequently measure in vivo as an indicator of oxidative stress. Oxidized L-Glutathione may be converted to L-glutathione by various reducing systems.
Side effects
There have been few studies on the side effects of glutathione use, and as a supplement, no associated side effects have been reported from consuming high glutathione only from diet. However, long-term use of glutathione supplements may reduce zinc levels, and inhaling glutathione can cause breathing problems in some people with mild asthma. In addition, there are concerns that the use of glutathione supplements may cause cramps and bloating or allergic reactions, accompanied by symptoms such as rashes. If you experience any of these side effects, stop taking the supplement and contact your doctor.
Purification Methods
Purify it by recrystallisation from 50% aqueous EtOH. Its solubility in H2O is 5%. Store it at 4o. [Li et al. J Am Chem Soc 76 225 1954, Berse et al. Can J Chem 37 1733 1959, Beilstein 4 IV 3168.]
References
[1] ABBASGHULAM. Construction of Genetically Encoded Biosensors to Monitor Subcellular Compartment-Specific Glutathione Response to Chemotherapeutic Drugs in Acute Myeloid Leukemia Cells.[J]. Analytical Chemistry, 2023, 95 5: 2838-2847. DOI:10.1021/acs.analchem.2c04255.
L-Glutathione Preparation Products And Raw materials
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View Lastest Price from L-Glutathione manufacturers
- Product
- L-Glutathione 27025-41-8
- Price
- US $35.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/Week
- Release date
- 2024-05-07
- Product
- L(-)-Glutathione 27025-41-8
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-09-19
- Product
- L(-)-Glutathione 27025-41-8
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-05