3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide

Product Name: 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide
CAS No.: 26638-66-4
Chemical Name: 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide
Synonyms: Tianeptine intermediates;Tianeptine sodium intermediates;Tianeptine InterMediate (the ninth step);Tianeptine Thiazepinyl Chloride IMpurity;5,8-Dichloro-11-Methyldibenzo[c,f]thiazepine 10,10-dioxide;5,8-DICHLORO-10-DIOXO-11-METHYL-DIBENZO[C,F][1,2]THIAZEPINE;3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepi...;3,11-DICHLORO-6,11-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE5,5-DIOXIDE;3,11-dichloro-6-methyl-11H-benzo[c][2,1]benzothiazepine 5,5-dioxide;3,11-Dichloro-6,11-dihydro-6-methyl-5,5-dioxodibenzo[c,f][1,2]thiazepine
CBNumber: CB1201158
Molecular Formula: C14H11Cl2NO2S
Formula Weight: 328.21
MOL File: 26638-66-4.mol

More

Less

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Property

Melting point:: >233oC (dec.)
Boiling point:: 445.3±55.0 °C(Predicted)
Density: 1.54±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly)
form: Solid
pka: -4.11±0.40(Predicted)
color: White
InChI: InChI=1S/C14H11Cl2NO2S/c1-17-12-5-3-2-4-10(12)14(16)11-7-6-9(15)8-13(11)20(17,18)19/h2-8,14H,1H3
InChIKey: FHICZIHQHGRZLE-UHFFFAOYSA-N
SMILES: S1(=O)(=O)C2=CC(Cl)=CC=C2C(Cl)C2=CC=CC=C2N1C

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: D434170
Product name: rac3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine5,5-Dioxide
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D434170
Product name: rac3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine5,5-Dioxide
Packaging: 25mg
Price: $55
Updated: 2021/12/16

Usbiological

Product number: 288650
Product name: rac 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide
Packaging: 10mg
Price: $446
Updated: 2021/12/16

Matrix Scientific

Product number: 072788
Product name: 3,11-Dichloro-6,11-dihydro-6-methyl-5,5-dioxodibenzo[c,f][1,2]thiazepine
Purity: 95+%
Packaging: 10g
Price: $448
Updated: 2021/12/16

AK Scientific

Product number: X0081
Product name: Dibenzo[c,f][1,2]thiazepine,3,11-dichloro-6,11-dihydro-6-methyl-,5,5-dioxide
Packaging: 25g
Price: $458
Updated: 2021/12/16

More

Less

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Intermediate in the preparation of Tianeptine and respective metabolites

Synthesis

26723-60-4

26638-66-4

General procedure for the synthesis of 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide from 3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin 5,5-dioxide: the compound of formula III (58.0 g) was suspended in dichloromethane ( 600 ml) and cooled to 0-10°C. Hydrogen chloride gas was passed into the suspension at 0-10°C and the reaction was kept for 2-4 hours. Upon completion of the reaction, the precipitate was collected by filtration and the resulting solid was dried to constant weight to afford the target product 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide in 90-95% yield.

References

[1] Patent: WO2010/70667, 2010, A2. Location in patent: Page/Page column 5
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 13, p. 2481 - 2496

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Suppliers

Canada 1 China 159 Germany 1 India 2 United States 11 Global 174

Ningbo Dingsheng New Material Co. , Ltd.

Tel: 0574-27961868
Email: jianghuanhuan@lumilan.cn
Country: China
ProdList: 10
Advantage: 58

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Tel: 029-029-029-81148696 18161915376
Email: 1040@dideu.com
Country: China
ProdList: 10001
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

More

Less

View Lastest Price from 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide manufacturers

Jinan Jianfeng Chemical Co., Ltd

Product: 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide 26638-66-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 5000kg
Release date: 2024-08-15

Hebei Chuanghai Biotechnology Co,.LTD

Product: Tianeptine 26638-66-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10 ton
Release date: 2024-08-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide 26638-66-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

26638-66-4, 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxideRelated Search:

Dihydromyrcenol 2-Chloro-5-chloromethylpyridine Tetramethylammonium hydroxide pentahydrate Zirconium dioxide Dichloromethylphenylsilane Dichlorodimethylsilane Carbon dioxide Sulfurous Acid Chlorine dioxide Rutile Quartz Thiophanate-methyl Tianeptine sodium salt Tianeptine Methyl Ester sulfur dioxide 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide SilicaDioxide

Dibenzo[c,f][1,2]thiazepine,3,11-dichloro-6,11-dihydro-6-methyl-,5,5-dioxide

3,11-DICHLORO-6,11-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE5,5-DIOXIDE

5,8-DICHLORO-10-DIOXO-11-METHYL-DIBENZO[C,F][1,2]THIAZEPINE

DIBENZO[C,F][1,2]THIAZEPINE,3,11-DICHLORO-6,11-DIHYDRO-6-METHYL-,5,5-DIOXIDE (8CI,9CI)

3-Chloro-6,11-dihydro-6-methyl-11-chlorodibenzo[c,f][1,2]thiazepine 5,5-dioxide

3,11-Dichloro-6,11-dihydro-6-methyl-5,5-dioxodibenzo[c,f][1,2]thiazepine

rac 3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-Dioxide

Tianeptine InterMediate (the ninth step)

3,11-DICHLORO-6,11-DIHYDRO-5,5-DIOXO-11-HYDROXY-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE

3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide

Tianeptine intermediates

5,8-Dichloro-11-Methyldibenzo[c,f]thiazepine 10,10-dioxide

Tianeptine Thiazepinyl Chloride IMpurity

3,11-Dichloro-6-Methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide

3,11-dichloro-6-methyl-11H-benzo[c][2,1]benzothiazepine 5,5-dioxide

11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide

3,11-Dichloro-6,11-dihydro-6-methyld26638-66-4ibenzo[c,f][1,2]thiazepine 5,5-dioxide

Tianeptine sodium intermediates

3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepi...

3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo [c, f] [1,2] thiodiazepine 5,5-dioxide

3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin 5,5-dioxide

26638-66-4

Intermediate

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

26638-66-4