ChemicalBook > CAS DataBase List > 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide

Product Name
3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide
CAS No.
26638-66-4
Chemical Name
3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide
Synonyms
Tianeptine intermediates;Tianeptine sodium intermediates;Tianeptine InterMediate (the ninth step);Tianeptine Thiazepinyl Chloride IMpurity;5,8-Dichloro-11-Methyldibenzo[c,f]thiazepine 10,10-dioxide;5,8-DICHLORO-10-DIOXO-11-METHYL-DIBENZO[C,F][1,2]THIAZEPINE;3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepi...;3,11-DICHLORO-6,11-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE5,5-DIOXIDE;3,11-dichloro-6-methyl-11H-benzo[c][2,1]benzothiazepine 5,5-dioxide;3,11-Dichloro-6,11-dihydro-6-methyl-5,5-dioxodibenzo[c,f][1,2]thiazepine
CBNumber
CB1201158
Molecular Formula
C14H11Cl2NO2S
Formula Weight
328.21
MOL File
26638-66-4.mol
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3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Property

Melting point:
>233oC (dec.)
Boiling point:
445.3±55.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly)
form 
Solid
pka
-4.11±0.40(Predicted)
color 
White
InChI
InChI=1S/C14H11Cl2NO2S/c1-17-12-5-3-2-4-10(12)14(16)11-7-6-9(15)8-13(11)20(17,18)19/h2-8,14H,1H3
InChIKey
FHICZIHQHGRZLE-UHFFFAOYSA-N
SMILES
S1(=O)(=O)C2=CC(Cl)=CC=C2C(Cl)C2=CC=CC=C2N1C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D434170
Product name
rac3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine5,5-Dioxide
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
D434170
Product name
rac3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine5,5-Dioxide
Packaging
25mg
Price
$55
Updated
2021/12/16
Usbiological
Product number
288650
Product name
rac 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide
Packaging
10mg
Price
$446
Updated
2021/12/16
Matrix Scientific
Product number
072788
Product name
3,11-Dichloro-6,11-dihydro-6-methyl-5,5-dioxodibenzo[c,f][1,2]thiazepine
Purity
95+%
Packaging
10g
Price
$448
Updated
2021/12/16
AK Scientific
Product number
X0081
Product name
Dibenzo[c,f][1,2]thiazepine,3,11-dichloro-6,11-dihydro-6-methyl-,5,5-dioxide
Packaging
25g
Price
$458
Updated
2021/12/16
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3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Intermediate in the preparation of Tianeptine and respective metabolites

Synthesis

26723-60-4

26638-66-4

General procedure for the synthesis of 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide from 3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin 5,5-dioxide: the compound of formula III (58.0 g) was suspended in dichloromethane ( 600 ml) and cooled to 0-10°C. Hydrogen chloride gas was passed into the suspension at 0-10°C and the reaction was kept for 2-4 hours. Upon completion of the reaction, the precipitate was collected by filtration and the resulting solid was dried to constant weight to afford the target product 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide in 90-95% yield.

References

[1] Patent: WO2010/70667, 2010, A2. Location in patent: Page/Page column 5
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 13, p. 2481 - 2496

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Preparation Products And Raw materials

Raw materials

Preparation Products

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3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Suppliers

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View Lastest Price from 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide manufacturers

Jinan Jianfeng Chemical Co., Ltd
Product
3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide 26638-66-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
5000kg
Release date
2024-08-15
Hebei Chuanghai Biotechnology Co,.LTD
Product
Tianeptine 26638-66-4
Price
US $10.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10 ton
Release date
2024-08-22
Zhuozhou Wenxi import and Export Co., Ltd
Product
3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide 26638-66-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

26638-66-4, 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxideRelated Search:

Dihydromyrcenol 2-Chloro-5-chloromethylpyridine Tetramethylammonium hydroxide pentahydrate Zirconium dioxide Dichloromethylphenylsilane Dichlorodimethylsilane Carbon dioxide Sulfurous Acid Chlorine dioxide Rutile Quartz Thiophanate-methyl Tianeptine sodium salt Tianeptine Methyl Ester sulfur dioxide 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide SilicaDioxide

  • Dibenzo[c,f][1,2]thiazepine,3,11-dichloro-6,11-dihydro-6-methyl-,5,5-dioxide
  • 3,11-DICHLORO-6,11-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE5,5-DIOXIDE
  • 5,8-DICHLORO-10-DIOXO-11-METHYL-DIBENZO[C,F][1,2]THIAZEPINE
  • DIBENZO[C,F][1,2]THIAZEPINE,3,11-DICHLORO-6,11-DIHYDRO-6-METHYL-,5,5-DIOXIDE (8CI,9CI)
  • 3-Chloro-6,11-dihydro-6-methyl-11-chlorodibenzo[c,f][1,2]thiazepine 5,5-dioxide
  • 3,11-Dichloro-6,11-dihydro-6-methyl-5,5-dioxodibenzo[c,f][1,2]thiazepine
  • rac 3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-Dioxide
  • Tianeptine InterMediate (the ninth step)
  • 3,11-DICHLORO-6,11-DIHYDRO-5,5-DIOXO-11-HYDROXY-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE
  • 3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide
  • Tianeptine intermediates
  • 5,8-Dichloro-11-Methyldibenzo[c,f]thiazepine 10,10-dioxide
  • Tianeptine Thiazepinyl Chloride IMpurity
  • 3,11-Dichloro-6-Methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide
  • 3,11-dichloro-6-methyl-11H-benzo[c][2,1]benzothiazepine 5,5-dioxide
  • 11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide
  • 3,11-Dichloro-6,11-dihydro-6-methyld26638-66-4ibenzo[c,f][1,2]thiazepine 5,5-dioxide
  • Tianeptine sodium intermediates
  • 3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepi...
  • 3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo [c, f] [1,2] thiodiazepine 5,5-dioxide
  • 3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin 5,5-dioxide
  • 26638-66-4
  • Intermediate
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
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  • 26638-66-4