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3-Aminocarbonyl-1-Boc-pyrrolidine

Product Name
3-Aminocarbonyl-1-Boc-pyrrolidine
CAS No.
122684-34-8
Chemical Name
3-Aminocarbonyl-1-Boc-pyrrolidine
Synonyms
1-Boc-3-pyrrolidinecarboxamide;1-BOC-PYRROLIDINE-3-CARBOXAMIDE;1-BOC-PYRROLIDINE-3-CARBOXYAMIDE;3-AMINOCARBONYL-1-BOC-PYRROLIDINE;(S)-1-BOC-PYRROLIDINE-3-CARBOXAMIDE;3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP;TERT-BUTYL 3-CARBAMOYLPYRROLIDINE-1-CARBOXYLATE;1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxamide;TERT-BUTYL 3-(AMINOCARBONYL)PYRROLIDINE-1-CARBOXYLATE;3-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber
CB1205707
Molecular Formula
C10H18N2O3
Formula Weight
214.26
MOL File
122684-34-8.mol
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3-Aminocarbonyl-1-Boc-pyrrolidine Property

Melting point:
117.0 to 121.0 °C
Boiling point:
370.1±31.0 °C(Predicted)
Density 
1.155±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
powder to crystal
pka
16.40±0.20(Predicted)
color 
White to Almost white
CAS DataBase Reference
122684-34-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000051
Product name
3-Carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Purity
Aldrich
Packaging
1g
Price
$216
Updated
2025/07/31
TCI Chemical
Product number
B5248
Product name
tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$119
Updated
2025/07/31
TCI Chemical
Product number
B5248
Product name
tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$355
Updated
2025/07/31
TRC
Product number
T135553
Product name
tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate
Packaging
500mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC147584
Product name
3-Carbamoyl-pyrrolidine-1-carboxylic acid tert-butylester
Packaging
2g
Price
$708
Updated
2021/12/16
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3-Aminocarbonyl-1-Boc-pyrrolidine Chemical Properties,Usage,Production

Uses

tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate is used for preparation and sulfuration of 1,2,4-thiadiazoles.

Synthesis

72925-16-7

122684-34-8

The general procedure for the synthesis of 1-BOC-pyrrolidine-3-carboxamide from (R)-1-Boc-3-carboxypyrrolidine was as follows: to a solution of 1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (5 g, 23.23 mmol) in anhydrous THF (100 mL) was added triethylamine (TEA, 4.69 g, 46.46 mmol) and isobutyl chloroformic acid ester (3.8 g, 27.87 mmol). The reaction mixture was stirred at 0 °C for 20 min. Subsequently, ammonia (NH3-H2O) was slowly added and stirring was continued for 2 h at room temperature. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (30 mL) and washed sequentially with saturated sodium carbonate solution (2 × 20 mL) and saturated sodium bicarbonate solution. The organic layer was then washed with citric acid solution (2 × 20 mL) to remove residual base. Finally, the organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product (2.39 g, 49% yield) as a yellow solid. Mass spectrometry (ESI) analysis showed: m/z = 159.0 [M + H]+.

References

[1] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 91
[2] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059
[3] Chemical Biology and Drug Design, 2016, p. 54 - 65

3-Aminocarbonyl-1-Boc-pyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Aminocarbonyl-1-Boc-pyrrolidine Suppliers

Americas 1 Canada 1 China 91 Europe 1 Germany 2 India 2 Japan 1 United Kingdom 3 United States 16 Global 118
AB Chemicals Inc.
Tel
--
Fax
--
Email
sales@abcheminc.com
Country
Canada
ProdList
1128
Advantage
47
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View Lastest Price from 3-Aminocarbonyl-1-Boc-pyrrolidine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Dideu Industries Group Limited
Product
3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-17
Shaanxi Dideu Medichem Co. Ltd
Product
3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 tons
Release date
2020-04-27

122684-34-8, 3-Aminocarbonyl-1-Boc-pyrrolidineRelated Search:

N-Vinyl-2-pyrrolidone tert-Butyl peroxyacetate N-Methyl-2-pyrrolidone tert-Butanol Buprofezin Povidone iodine Tris(trimethylsilyl)phosphate BUTYL OLEATE tert-Butyl acetate Butyl acetate Cyhalofop-butyl 3-Pyrrolidinecarboxylic acid Polyvinylpyrrolidone Pyrrolidine METHYL-2-PYRROLIDONE (R)-1-Boc-3-(aminomethyl)pyrrolidine 1-Boc-Pyrrolidine 3-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

  • 3-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 3-AMINOCARBONYL-1-BOC-PYRROLIDINE
  • (S)-1-BOC-PYRROLIDINE-3-CARBOXAMIDE
  • 1-BOC-PYRROLIDINE-3-CARBOXAMIDE
  • TERT-BUTYL 3-(AMINOCARBONYL)PYRROLIDINE-1-CARBOXYLATE
  • TERT-BUTYL 3-CARBAMOYLPYRROLIDINE-1-CARBOXYLATE
  • 1-BOC-PYRROLIDINE-3-CARBOXYAMIDE
  • N-[2-oxo-3-(trifluoromethyl)-3-piperidinyl]carbamic acid tert-butyl ester
  • 1-Pyrrolidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester
  • 1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxamide
  • 1-Boc-3-pyrrolidinecarboxamide
  • 3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP
  • 122684-34-8
  • 123751
  • pharmacetical