ChemicalBook > CAS DataBase List > 3-Aminocarbonyl-1-Boc-pyrrolidine

3-Aminocarbonyl-1-Boc-pyrrolidine

Product Name: 3-Aminocarbonyl-1-Boc-pyrrolidine
CAS No.: 122684-34-8
Chemical Name: 3-Aminocarbonyl-1-Boc-pyrrolidine
Synonyms: 1-Boc-3-pyrrolidinecarboxamide;1-BOC-PYRROLIDINE-3-CARBOXAMIDE;1-BOC-PYRROLIDINE-3-CARBOXYAMIDE;3-AMINOCARBONYL-1-BOC-PYRROLIDINE;(S)-1-BOC-PYRROLIDINE-3-CARBOXAMIDE;3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP;TERT-BUTYL 3-CARBAMOYLPYRROLIDINE-1-CARBOXYLATE;1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxamide;TERT-BUTYL 3-(AMINOCARBONYL)PYRROLIDINE-1-CARBOXYLATE;3-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber: CB1205707
Molecular Formula: C10H18N2O3
Formula Weight: 214.26
MOL File: 122684-34-8.mol

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3-Aminocarbonyl-1-Boc-pyrrolidine Property

Melting point:: 117.0 to 121.0 °C
Boiling point:: 370.1±31.0 °C(Predicted)
Density: 1.155±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder to crystal
pka: 16.40±0.20(Predicted)
color: White to Almost white
CAS DataBase Reference: 122684-34-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000051
Product name: 3-Carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

TCI Chemical

Product number: B5248
Product name: tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $119
Updated: 2025/07/31

TCI Chemical

Product number: B5248
Product name: tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $355
Updated: 2025/07/31

TRC

Product number: T135553
Product name: tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC147584
Product name: 3-Carbamoyl-pyrrolidine-1-carboxylic acid tert-butylester
Packaging: 100mg
Price: $68
Updated: 2021/12/16

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3-Aminocarbonyl-1-Boc-pyrrolidine Chemical Properties,Usage,Production

Uses

tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate is used for preparation and sulfuration of 1,2,4-thiadiazoles.

Synthesis

72925-16-7

122684-34-8

The general procedure for the synthesis of 1-BOC-pyrrolidine-3-carboxamide from (R)-1-Boc-3-carboxypyrrolidine was as follows: to a solution of 1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (5 g, 23.23 mmol) in anhydrous THF (100 mL) was added triethylamine (TEA, 4.69 g, 46.46 mmol) and isobutyl chloroformic acid ester (3.8 g, 27.87 mmol). The reaction mixture was stirred at 0 °C for 20 min. Subsequently, ammonia (NH3-H2O) was slowly added and stirring was continued for 2 h at room temperature. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (30 mL) and washed sequentially with saturated sodium carbonate solution (2 × 20 mL) and saturated sodium bicarbonate solution. The organic layer was then washed with citric acid solution (2 × 20 mL) to remove residual base. Finally, the organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product (2.39 g, 49% yield) as a yellow solid. Mass spectrometry (ESI) analysis showed: m/z = 159.0 [M + H]+.

References

[1] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 91
[2] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059
[3] Chemical Biology and Drug Design, 2016, p. 54 - 65

3-Aminocarbonyl-1-Boc-pyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Aminocarbonyl-1-Boc-pyrrolidine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Dideu Industries Group Limited

Product: 3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-06-17

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 tons
Release date: 2020-04-27

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122684-34-8

123751

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