3-Aminocarbonyl-1-Boc-pyrrolidine
- Product Name
- 3-Aminocarbonyl-1-Boc-pyrrolidine
- CAS No.
- 122684-34-8
- Chemical Name
- 3-Aminocarbonyl-1-Boc-pyrrolidine
- Synonyms
- 1-Boc-3-pyrrolidinecarboxamide;1-BOC-PYRROLIDINE-3-CARBOXAMIDE;1-BOC-PYRROLIDINE-3-CARBOXYAMIDE;3-AMINOCARBONYL-1-BOC-PYRROLIDINE;(S)-1-BOC-PYRROLIDINE-3-CARBOXAMIDE;3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP;TERT-BUTYL 3-CARBAMOYLPYRROLIDINE-1-CARBOXYLATE;1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxamide;TERT-BUTYL 3-(AMINOCARBONYL)PYRROLIDINE-1-CARBOXYLATE;3-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CBNumber
- CB1205707
- Molecular Formula
- C10H18N2O3
- Formula Weight
- 214.26
- MOL File
- 122684-34-8.mol
3-Aminocarbonyl-1-Boc-pyrrolidine Property
- Melting point:
- 117.0 to 121.0 °C
- Boiling point:
- 370.1±31.0 °C(Predicted)
- Density
- 1.155±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder to crystal
- pka
- 16.40±0.20(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 122684-34-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000051
- Product name
- 3-Carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- B5248
- Product name
- tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $119
- Updated
- 2025/07/31
- Product number
- B5248
- Product name
- tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $355
- Updated
- 2025/07/31
- Product number
- T135553
- Product name
- tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FC147584
- Product name
- 3-Carbamoyl-pyrrolidine-1-carboxylic acid tert-butylester
- Packaging
- 2g
- Price
- $708
- Updated
- 2021/12/16
3-Aminocarbonyl-1-Boc-pyrrolidine Chemical Properties,Usage,Production
Uses
tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate is used for preparation and sulfuration of 1,2,4-thiadiazoles.
Synthesis
72925-16-7
122684-34-8
The general procedure for the synthesis of 1-BOC-pyrrolidine-3-carboxamide from (R)-1-Boc-3-carboxypyrrolidine was as follows: to a solution of 1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (5 g, 23.23 mmol) in anhydrous THF (100 mL) was added triethylamine (TEA, 4.69 g, 46.46 mmol) and isobutyl chloroformic acid ester (3.8 g, 27.87 mmol). The reaction mixture was stirred at 0 °C for 20 min. Subsequently, ammonia (NH3-H2O) was slowly added and stirring was continued for 2 h at room temperature. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (30 mL) and washed sequentially with saturated sodium carbonate solution (2 × 20 mL) and saturated sodium bicarbonate solution. The organic layer was then washed with citric acid solution (2 × 20 mL) to remove residual base. Finally, the organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product (2.39 g, 49% yield) as a yellow solid. Mass spectrometry (ESI) analysis showed: m/z = 159.0 [M + H]+.
References
[1] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 91
[2] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059
[3] Chemical Biology and Drug Design, 2016, p. 54 - 65
3-Aminocarbonyl-1-Boc-pyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Aminocarbonyl-1-Boc-pyrrolidine Suppliers
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View Lastest Price from 3-Aminocarbonyl-1-Boc-pyrrolidine manufacturers
- Product
- 3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-17
- Product
- 3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 tons
- Release date
- 2020-04-27