ChemicalBook > CAS DataBase List > ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE

Product Name: ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE
CAS No.: 124755-24-4
Chemical Name: ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE
Synonyms: ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE;Ethyl 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]acetate;Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate;Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate 97%;Di(3,3,3-trifluoroethyl)(ethoxycarbonylmethyl)phosphonate;[Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid ethyl ester;[BIS-(2,2,2-TRIFLUORO-ETHOXY)-PHOSPHORYL]-ACETIC ACID METHYL ESTER;Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, ethyl ester
CBNumber: CB1206274
Molecular Formula: C8H11F6O5P
Formula Weight: 332.13
MOL File: 124755-24-4.mol

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ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Property

Boiling point:: 249-250 °C(lit.)
Density: 1.403 g/mL at 25 °C(lit.)
refractive index: n20/D 1.3730(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C, stored under nitrogen
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C8H11F6O5P/c1-2-17-6(15)3-20(16,18-4-7(9,10)11)19-5-8(12,13)14/h2-5H2,1H3
InChIKey: HBYHPBCAZBLFTD-UHFFFAOYSA-N
SMILES: C(OCC)(=O)CP(OCC(F)(F)F)(OCC(F)(F)F)=O

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E677510
Product name: Ethyl[Bis(2,2,2-trifluoroethoxy)phosphinyl]acetate
Packaging: 1g
Price: $100
Updated: 2021/12/16

Ark Pharm

Product number: P000231421
Product name: Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate
Purity: 97%
Packaging: 1g
Price: $33
Updated: 2021/12/16

Ark Pharm

Product number: P000231421
Product name: Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate
Purity: 97%
Packaging: 5g
Price: $102
Updated: 2021/12/16

Ark Pharm

Product number: P000231421
Product name: Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate
Purity: 97%
Packaging: 10g
Price: $170
Updated: 2021/12/16

AK Scientific

Product number: Z4021
Product name: Ethyl2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate
Packaging: 5g
Price: $237
Updated: 2021/12/16

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ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Chemical Properties,Usage,Production

Uses

Ethyl [Bis(2,2,2-trifluoroethoxy)phosphinyl]acetate is a reagent used in the preparation of spiroketal EBC-23; an anticancer agent, scytonemin A; a novel calcium antagonist and other useful organic compounds.

Synthesis

To stirred solution of 18-crown-6 (4.40 g, 16.65 mmol), THF (20 mL), and bis (2,2,2-trifluoroethyl) phosphite (1) (0.55 mL, 3.75 mmol), KHMDS (8.0 mL, 4.00 mmol, 0.5 M in toluene) was added via syringe in a dropwise manner at -78 oC. Ethyl chloroacetate (0.35 mL, 3.30 mmol) was added to the flask after 15 min. The reaction flask was allowed to warm to room temperature and stir for 4 hr. After standard workup procedure, the crude product was then purified by flash column chromatography (2:1-1:1 hexanes:EtOAc, Rf = 0.25 in 2:1 hexanes:EtOAc) yielding Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate (808 mg, 2.43 mmol, 73.4%) as a yellow syrup.

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Suppliers

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View Lastest Price from ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate 124755-24-4
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50 tons
Release date: 2020-01-17

124755-24-4, ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATERelated Search:

ETHYL (4-IODOBENZOYL)ACETATE BIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE PHOSPHONOACETIC ACID BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE

Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate

[BIS-(2,2,2-TRIFLUORO-ETHOXY)-PHOSPHORYL]-ACETIC ACID METHYL ESTER

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE

Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate 97%

Di(3,3,3-trifluoroethyl)(ethoxycarbonylmethyl)phosphonate

[Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid ethyl ester

Acetic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, ethyl ester

Ethyl 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]acetate

124755-24-4

C8H11F6O5P

Organic Building Blocks

Building Blocks

Phosphonates/Phosphinates

Phosphorus Compounds

Organic Building Blocks

Phosphonates/Phosphinates

Phosphorus Compounds