ChemicalBook > CAS DataBase List > 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole

1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole

Product Name
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
CAS No.
449758-17-2
Chemical Name
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
Synonyms
1-(Tetrahydro-pyran-2-yl)-1H-pyrazole;1-(oxan-2-yl)pyrazole;1-(2-Tetrahydropyranyl);1-(oxan-2-yl)-1H-pyrazole;1-(2-Tetrahydropyranyl)pyrazole;1-(2-Tetrahydropyranyl)-1H-pyrazole;1-(2-Tetrahydropyranyl)-1H-pyrazole 95%;1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole;1H-Pyrazole,1-(tetrahydro-2H-pyran-2-yl)-;1-(2-Tetrahydropyranyl)-1H-pyrazole
CBNumber
CB12092927
Molecular Formula
C8H12N2O
Formula Weight
152.19
MOL File
449758-17-2.mol
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1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole Property

Boiling point:
269.8±33.0℃ (760 Torr)
Density 
1.084 g/mL at 25 °C
refractive index 
n20/D 1.503
Flash point:
104 °C
storage temp. 
Sealed in dry,Room Temperature
form 
Liquid
pka
2.08±0.19(Predicted)
color 
Colorless to pale yellow
InChI
InChI=1S/C8H12N2O/c1-2-7-11-8(4-1)10-6-3-5-9-10/h3,5-6,8H,1-2,4,7H2
InChIKey
IMZWSOSYNFVECD-UHFFFAOYSA-N
SMILES
N1(C2OCCCC2)C=CC=N1
CAS DataBase Reference
449758-17-2
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Safety

WGK Germany 
3
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
694665
Product name
1-(2-Tetrahydropyranyl)-1H-pyrazole
Purity
95%
Packaging
1g
Price
$112
Updated
2023/06/20
Sigma-Aldrich
Product number
694665
Product name
1-(2-Tetrahydropyranyl)-1H-pyrazole
Purity
95%
Packaging
5g
Price
$136
Updated
2023/06/20
TCI Chemical
Product number
T3408
Product name
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
Purity
>98.0%(GC)
Packaging
1g
Price
$28
Updated
2025/07/31
TCI Chemical
Product number
T3408
Product name
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
Purity
>98.0%(GC)
Packaging
5g
Price
$112
Updated
2025/07/31
TRC
Product number
T889560
Product name
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
Packaging
25g
Price
$75
Updated
2021/12/16
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1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Uses

1-THP-protected 1H-pyrazole as the valuable starter for the preparation of pyrazolylboronic ester, which is useful in the synthesis of pyrazoloisoindoles and other pyrazole derivatives

Synthesis

110-87-2

288-13-1

449758-17-2

General procedure for the synthesis of 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole from 3,4-dihydro-2H-pyran and pyrazole: cf. Example 1 [1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl]boronic acid. Pyrazole (14.3 g, 0.21 mol) was mixed with 3,4-dihydro-2H-pyran (29 mL, 0.32 mol) and trifluoroacetic acid (0.1 mL, 0.0013 mol) and heated under reflux conditions for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by the addition of sodium hydride (60% dispersed in mineral oil, 0.2 g, 0.008 mol) and stirred for 10 min. Finally, the reaction mixture was purified by reduced pressure distillation (60-65 °C, 0.5-1 mmHg) to afford the target product 1-(tetrahydropyran-2-yl)-1H-pyrazole (30.8 g, 96% yield).

References

[1] Tetrahedron Letters, 2006, vol. 47, # 27, p. 4665 - 4669
[2] Tetrahedron Letters, 2007, vol. 48, # 23, p. 4123 - 4126
[3] Journal of Organic Chemistry, 2016, vol. 81, # 4, p. 1718 - 1722
[4] Patent: WO2017/66606, 2017, A1. Location in patent: Page/Page column 49
[5] Patent: WO2007/138072, 2007, A2. Location in patent: Page/Page column 54

1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole Suppliers

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View Lastest Price from 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole manufacturers

LY Global chemicals co.,ltd .
Product
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole 449758-17-2
Price
US $0.00/kg
Min. Order
1kg
Purity
95.0%min
Supply Ability
1000kg
Release date
2023-03-10
Career Henan Chemical Co
Product
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole 449758-17-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-25

449758-17-2, 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazoleRelated Search:

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