1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
- Product Name
- 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
- CAS No.
- 449758-17-2
- Chemical Name
- 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
- Synonyms
- 1-(Tetrahydro-pyran-2-yl)-1H-pyrazole;1-(oxan-2-yl)pyrazole;1-(2-Tetrahydropyranyl);1-(oxan-2-yl)-1H-pyrazole;1-(2-Tetrahydropyranyl)pyrazole;1-(2-Tetrahydropyranyl)-1H-pyrazole;1-(2-Tetrahydropyranyl)-1H-pyrazole 95%;1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole;1H-Pyrazole,1-(tetrahydro-2H-pyran-2-yl)-;1-(2-Tetrahydropyranyl)-1H-pyrazole
- CBNumber
- CB12092927
- Molecular Formula
- C8H12N2O
- Formula Weight
- 152.19
- MOL File
- 449758-17-2.mol
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole Property
- Boiling point:
- 269.8±33.0℃ (760 Torr)
- Density
- 1.084 g/mL at 25 °C
- refractive index
- n20/D 1.503
- Flash point:
- 104 °C
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- pka
- 2.08±0.19(Predicted)
- color
- Colorless to pale yellow
- InChI
- InChI=1S/C8H12N2O/c1-2-7-11-8(4-1)10-6-3-5-9-10/h3,5-6,8H,1-2,4,7H2
- InChIKey
- IMZWSOSYNFVECD-UHFFFAOYSA-N
- SMILES
- N1(C2OCCCC2)C=CC=N1
- CAS DataBase Reference
- 449758-17-2
Safety
- WGK Germany
- 3
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 694665
- Product name
- 1-(2-Tetrahydropyranyl)-1H-pyrazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $112
- Updated
- 2023/06/20
- Product number
- 694665
- Product name
- 1-(2-Tetrahydropyranyl)-1H-pyrazole
- Purity
- 95%
- Packaging
- 5g
- Price
- $136
- Updated
- 2023/06/20
- Product number
- T3408
- Product name
- 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- T3408
- Product name
- 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- T889560
- Product name
- 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole Chemical Properties,Usage,Production
Uses
1-THP-protected 1H-pyrazole as the valuable starter for the preparation of pyrazolylboronic ester, which is useful in the synthesis of pyrazoloisoindoles and other pyrazole derivatives
Synthesis
110-87-2
288-13-1
449758-17-2
General procedure for the synthesis of 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole from 3,4-dihydro-2H-pyran and pyrazole: cf. Example 1 [1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl]boronic acid. Pyrazole (14.3 g, 0.21 mol) was mixed with 3,4-dihydro-2H-pyran (29 mL, 0.32 mol) and trifluoroacetic acid (0.1 mL, 0.0013 mol) and heated under reflux conditions for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by the addition of sodium hydride (60% dispersed in mineral oil, 0.2 g, 0.008 mol) and stirred for 10 min. Finally, the reaction mixture was purified by reduced pressure distillation (60-65 °C, 0.5-1 mmHg) to afford the target product 1-(tetrahydropyran-2-yl)-1H-pyrazole (30.8 g, 96% yield).
References
[1] Tetrahedron Letters, 2006, vol. 47, # 27, p. 4665 - 4669
[2] Tetrahedron Letters, 2007, vol. 48, # 23, p. 4123 - 4126
[3] Journal of Organic Chemistry, 2016, vol. 81, # 4, p. 1718 - 1722
[4] Patent: WO2017/66606, 2017, A1. Location in patent: Page/Page column 49
[5] Patent: WO2007/138072, 2007, A2. Location in patent: Page/Page column 54
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole manufacturers
- Product
- 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole 449758-17-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 95.0%min
- Supply Ability
- 1000kg
- Release date
- 2023-03-10
- Product
- 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole 449758-17-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25