ChemicalBook > CAS DataBase List > ESTETROL

ESTETROL

Product Name: ESTETROL
CAS No.: 15183-37-6
Chemical Name: ESTETROL
Synonyms: E 4;UBE4A;UBOX3;UFD2A;HDNB1;Donesta;ESTETROL;KIAA0126;KIAA0684;MGC133315
CBNumber: CB1210710
Molecular Formula: C18H24O4
Formula Weight: 304.38
MOL File: 15183-37-6.mol

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ESTETROL Property

Melting point:: 233-236°C
Boiling point:: 491.9±45.0 °C(Predicted)
Density: 1.343±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO: soluble20mg/mL, clear
pka: 10.22±0.70(Predicted)
form: powder
color: white to beige
optical activity: [α]/D +125 to +135, c = 1 in ethanol
InChI: InChI=1/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12-,13-,14-,15-,16-,17+,18+/s3
InChIKey: AJIPIJNNOJSSQC-VRHMYLLRNA-N
SMILES: [C@@]12([H])CCC3C=C(O)C=CC=3[C@@]1([H])CC[C@]1(C)[C@H]([C@H](O)[C@H](O)[C@@]21[H])O |&1:0,11,15,17,18,20,22,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H351Suspected of causing cancer

H360May damage fertility or the unborn child

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1523
Product name: Estetrol
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $213.75
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1523
Product name: Estetrol
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $625.8
Updated: 2025/07/31

Cayman Chemical

Product number: 18232
Product name: Estetrol
Purity: ≥95%
Packaging: 500μg
Price: $35
Updated: 2021/12/16

Cayman Chemical

Product number: 18232
Product name: Estetrol
Purity: ≥95%
Packaging: 1mg
Price: $63
Updated: 2021/12/16

Cayman Chemical

Product number: 18232
Product name: Estetrol
Purity: ≥95%
Packaging: 5mg
Price: $158
Updated: 2021/12/16

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ESTETROL Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium). In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.

Uses

A metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.

Definition

ChEBI: Estetrol is a 3-hydroxy steroid that is 17beta-estradiol which has been substituted at the 15alpha and 16alpha positions by two additional hydroxy groups. It is a natural estrogen produced exclusively during pregnancy by the fetal liver. It has a role as an estrogen, an estrogen receptor agonist, a human metabolite, a human xenobiotic metabolite and an oral contraceptive. It is a 3-hydroxy steroid, a 17beta-hydroxy steroid, a 16alpha-hydroxy steroid, a 15alpha-hydroxy steroid and a steroid hormone. It derives from a hydride of an estrane.

in vivo

Estetrol (0.6 and 6 mg/kg/day, mixed in diet, 12 weeks) induces an atheroprotective effect in mice, with an ERα‐dependent manner^[3].
Estetrol (0.03-3.0 mg/kg, p.o., twice daily for four consecutive days) inhibits ovulation in rats^[5].

Animal Model:	Four‐week‐old ovariectomized ERα^+/+LDL‐r^?/? or ERα^?/?LDL‐r^?/? mice were switched to atherogenic diet from the age of 6-18 weeks^[1]
Dosage:	0.6 or 6 mg/kg/day
Administration:	mixed in atherogenic diet, 12 weeks
Result:	Decreased total plasma cholesterol at 6 mg/kg/day in ERα^+/+LDLr^?/? but not in ERα^?/?LDLr^?/? mice. Prevented lipid deposition in ovariectomized ERα^+/+LDLr^?/? mice.

ESTETROL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ESTETROL manufacturers

Wuhan Fortuna Chemical Co.,Ltd

Product: ESTETROL 15183-37-6
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 2000G
Release date: 2025-08-30

15183-37-6, ESTETROLRelated Search:

1,3,5(10)-ESTRATRIEN-2,3,15-ALPHA, 16-ALPHA, 17-BETA-PENTOL 2-METHYL ETHER 1,3,5(10)-ESTRATRIEN-3,15-ALPHA, 16-ALPHA, 17-BETA-TETROL TETRA ACETATE Estriol 1,3,5(10)-ESTRATRIEN-3,15-ALPHA, 17-BETA-TRIOL ESTETROL Fulvestrant β-Estradiol Elacestrant

1,3,5(10)-ESTRATRIEN-3,15-ALPHA, 16-ALPHA, 17-BETA-TETROL

15-ALPHA-HYDROXYESTRIOL

E 4

ESTETROL

(15a,16a,17)-Estra-1,3,5(10)-triene-3,15,16,17-tetrol

15a-Hydroxyestriol

3,15a,16a,17-Tetrahydroxyestra-1,3,5(10)-triene

Estra-1,3,5(10)-triene-3,15a,16a,17-tetrol

15α-Hydroxyestriol

Estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol

(15α,16α,17β)-Estra-1,3,5(10)-triene-3,15,16,17-tetrol

3,15α,16α,17β-Tetrahydroxyestra-1,3,5(10)-triene

KIAA0126

MGC133315

UBE4A

(8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol

Estra-1,3,5(10)-triene-3,15,16,17-tetrol, (15α,16α,17β)-

1, 3, 5(10)-ESTRATRIEN-3, 15α, 16α, 17β-TETROL

(8R,9S,13S,14S,15R,16R,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,15,16,17-tetraol

Donesta

Estetrol, 10 mM in DMSO

Estetrol (E4)

UBOX3

UFD2A

HDNB1

KIAA0684

15183-37-6

Intermediates & Fine Chemicals

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Steroids