BCTC

Product Name: BCTC
CAS No.: 393514-24-4
Chemical Name: BCTC
Synonyms: BCTC;BCTC, 10 mM in DMSO;BCTC, inhibitor of TRPV1;N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide;1-Piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-diMethylethyl)phenyl]-1-piperazinecarboxaMide (BCTC)
CBNumber: CB12122071
Molecular Formula: C20H25ClN4O
Formula Weight: 372.89
MOL File: 393514-24-4.mol

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BCTC Property

Melting point:: 150-152℃
Boiling point:: 561.6±50.0 °C(Predicted)
Density: 1.229±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: >10mg/mL
pka: 13.95±0.70(Predicted)
form: powder
color: white to beige
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stord at -20°C for up to 2 months.
InChI: InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
InChIKey: ROGUAPYLUCHQGK-UHFFFAOYSA-N
SMILES: N1(C(NC2=CC=C(C(C)(C)C)C=C2)=O)CCN(C2=NC=CC=C2Cl)CC1

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0355
Product name: BCTC
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $94.43
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0355
Product name: BCTC
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $275
Updated: 2025/07/31

Cayman Chemical

Product number: 10006309
Product name: BCTC
Purity: ≥98%
Packaging: 5mg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 10006309
Product name: BCTC
Purity: ≥98%
Packaging: 10mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 10006309
Product name: BCTC
Purity: ≥98%
Packaging: 50mg
Price: $322
Updated: 2024/03/01

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BCTC Chemical Properties,Usage,Production

Description

BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) blocker, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Displays analgesic activity in rat models of neuropathic pain. BCTC is orally active and cell permeable.

Uses

BCTC is a antagonists of TRPA1 and TRPV1, a non-selective cation channel gated by noxious heat, vanilloids and extracellular protons. BCTC inhibits both capsaicin and proton activation.

Definition

ChEBI: 1-piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-n-[4-(1,1-dimethylethyl)phenyl]- is a member of piperazines and a member of pyridines.

in vivo

BCTC (1-30 mg/kg; Oral gavage; Single dose) can inhibit inflammatory and neuropathic heat pain and mechanical hyperalgesia in Sprague-Dawley rats by targeting VR1, which has analgesic effect^[2].
BCTC (10-100 mg/kg; Oral gavage, Twice daily for 4 weeks) improves the insulin resistance and systemic glucose and lipid metabolism, and increase insulin secretion in diabetic ob/ob mice^[5].

Animal Model:	Capsaicin-induced Sprague-Dawley rats model^[2]
Dosage:	1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:	Oral gavage (p.o.), Single dose. Before capsaicin (HY-10448) treatment (30 μg; intraplantar injection; Single dose)
Result:	Inhibited capsaicin-mediated thermal hyperalgesia in a dose-dependent manner.

Animal Model:	Freund’s complete adjuvant (FCA) Sprague-Dawley rats model^[2]
Dosage:	1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:	Oral gavage (p.o.), Single dose. After 100 % FAC treatment (50 μL; intraplantar injection; Single dose)
Result:	Significantly reduced FAC-induced inflammation-related thermal pain and mechanical hyperalgesia, and extended the inhibitory effect of mechanical hyperalgesia to 6 h at high doses (10 mg/kg, 30 mg/kg).

Animal Model:	Partial sciatic nerve ligation Sprague-Dawley rats model^[2]
Dosage:	1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:	Oral gavage (p.o.), Single dose. After partial sciatic nerve ligation.
Result:	Reduced post-operative abnormal tactile pain and mechanical hyperalgesia in a dose-dependent manner.

Animal Model:	Particularly strong insulin resistance and hyperinsulinemia ob/ob mice model^[5]
Dosage:	10 mg/kg, 30 mg/kg, 100 mg/kg
Administration:	Oral gavage (p.o.); Twice daily for 4 weeks
Result:	Reduced plasma triglyceride and glucose area under the curve (AUC) level. Decreased calcitonin gene-related peptide (CGRP) levels in a dose-dependent manner.

storage

Room temperature

References

[1] KENNETH J VALENZANO. N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 306 1: 377-386. DOI:10.1124/jpet.102.045674
[2] JAMES D POMONIS. N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain.[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 306 1: 387-393. DOI:10.1124/jpet.102.046268

BCTC Preparation Products And Raw materials

Raw materials

Preparation Products

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BCTC Suppliers

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View Lastest Price from BCTC manufacturers

Career Henan Chemical Co

Product: BCTC 393514-24-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10t
Release date: 2019-12-20

393514-24-4, BCTCRelated Search:

Oleoyl Ethanolamide AMG 9810 4'-CHLORO-3-METHOXYCINNAMANILIDE Evodiamine Eugenol Capsaicin 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Dofetilide A 967079 VERATRIDINE 1,3,5-Tri-tert-butylbenzene PSY-279 OLDA AA-5-HT IBTU PPAHV ISOVELLERAL JYL-273

BCTC

4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide

4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-diMethylethyl)phenyl]-1-piperazinecarboxaMide (BCTC)

N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide

1-Piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-

BCTC, inhibitor of TRPV1

BCTC, 10 mM in DMSO

393514-24-4

Vanilloid/TRPV channel