Indibulin

ChemicalBook > CAS DataBase List > Indibulin

Product Name: Indibulin
CAS No.: 204205-90-3
Chemical Name: Indibulin
Synonyms: ZIO 301;Indibulin;Nascapine;lindiblin;2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl-;2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide;Indibulin,Apoptosis,ZIO301,D24851,Inhibitor,inhibit,ZIO-301,D-24851,Microtubule/Tubulin;2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide ISO 9001：2015 REACH
CBNumber: CB12128730
Molecular Formula: C22H16ClN3O2
Formula Weight: 389.83
MOL File: 204205-90-3.mol

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Indibulin Property

Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:33.25(Max Conc. mg/mL);85.29(Max Conc. mM)
form: A solid
pka: 9.38±0.70(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 3728
Product name: Indibulin
Purity: ≥98%(HPLC)
Packaging: 10
Price: $177
Updated: 2021/12/16

Tocris

Product number: 3728
Product name: Indibulin
Purity: ≥98%(HPLC)
Packaging: 50
Price: $735
Updated: 2021/12/16

TRC

Product number: I533753
Product name: Indibulin
Packaging: 25mg
Price: $195
Updated: 2021/12/16

Usbiological

Product number: 255508
Product name: Indibulin
Packaging: 10mg
Price: $423
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002198
Product name: D-24851
Purity: 95.00%
Packaging: 10MG
Price: $495
Updated: 2021/12/16

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Indibulin Chemical Properties,Usage,Production

Description

Indibulin (D-24851; ZIO-301), a novel synthetic small molecule microtubule inhibitor, destabilizes microtubules and has antitumor activity but does not exhibit neurotoxicity in preclinical animal studies. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis. The drug can discriminate between highly posttranslationally modified tubulin present in mature neuronal microtubules, and less-modified tubulin present in immature neuronal or nonneuronal microtubules.

Uses

Indibulin is a chemotherapeutic drug that destabilizes microtubules and is used to treat aggressive and heterogenous cancers, including breast cancer.

Biological Activity

Indibulin is a microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3 μM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036 - 0.285 μM). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.

storage

Desiccate at -20°C

Mode of action

Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines.

References

Indibulin, a Novel Microtubule Inhibitor, Discriminates between Mature Neuronal and Nonneuronal Tubulin
https://www.rndsystems.com/products/indibulin_3728
https://pubchem.ncbi.nlm.nih.gov/compound/2929

Indibulin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Indibulin manufacturers

Career Henan Chemica Co

Product: 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide 204205-90-3
Price: US $9.80-8.00/KG
Min. Order: 1KG
Purity: 95%~99.99%
Supply Ability: 10 MT/ Month
Release date: 2020-10-28

Shaanxi Dideu Medichem Co. Ltd

Product: 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide 204205-90-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

204205-90-3, IndibulinRelated Search:

4'-CHLOROACETANILIDE N,N-Dimethylacetamide DIACETAMIDE Acetamide Acetaminophen Thioacetamide Chloroacetamide Palifosfamide Benzyl chloride 2-(1H-INDOL-3-YL)-2-OXO-ETHYLAMINE HCL 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Indibulin

2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide

Nascapine

ZIO 301

2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide

Indibulin

2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide

lindiblin

1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl-

2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide ISO 9001：2015 REACH

Indibulin,Apoptosis,ZIO301,D24851,Inhibitor,inhibit,ZIO-301,D-24851,Microtubule/Tubulin

204205-90-3

C22H16CIN3O2

Anticancer.