Indibulin
- Product Name
- Indibulin
- CAS No.
- 204205-90-3
- Chemical Name
- Indibulin
- Synonyms
- ZIO 301;Indibulin;Nascapine;lindiblin;2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl-;2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide;Indibulin,Apoptosis,ZIO301,D24851,Inhibitor,inhibit,ZIO-301,D-24851,Microtubule/Tubulin;2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide ISO 9001：2015 REACH
- CBNumber
- CB12128730
- Molecular Formula
- C22H16ClN3O2
- Formula Weight
- 389.83
- MOL File
- 204205-90-3.mol
Indibulin Property
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:33.25(Max Conc. mg/mL);85.29(Max Conc. mM)
- form
- A solid
- pka
- 9.38±0.70(Predicted)
- color
- Off-white to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 3728
- Product name
- Indibulin
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $177
- Updated
- 2021/12/16
- Product number
- 3728
- Product name
- Indibulin
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $735
- Updated
- 2021/12/16
- Product number
- I533753
- Product name
- Indibulin
- Packaging
- 25mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 255508
- Product name
- Indibulin
- Packaging
- 10mg
- Price
- $423
- Updated
- 2021/12/16
- Product number
- API0002198
- Product name
- D-24851
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $495
- Updated
- 2021/12/16
Indibulin Chemical Properties,Usage,Production
Description
Indibulin (D-24851; ZIO-301), a novel synthetic small molecule microtubule inhibitor, destabilizes microtubules and has antitumor activity but does not exhibit neurotoxicity in preclinical animal studies. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis. The drug can discriminate between highly posttranslationally modified tubulin present in mature neuronal microtubules, and less-modified tubulin present in immature neuronal or nonneuronal microtubules.
Uses
Indibulin is a chemotherapeutic drug that destabilizes microtubules and is used to treat aggressive and heterogenous cancers, including breast cancer.
Biological Activity
Indibulin is a microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3 μM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036 - 0.285 μM). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.
storage
Desiccate at -20°C
Mode of action
Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines.
References
Indibulin, a Novel Microtubule Inhibitor, Discriminates between Mature Neuronal and Nonneuronal Tubulin
https://www.rndsystems.com/products/indibulin_3728
https://pubchem.ncbi.nlm.nih.gov/compound/2929
Indibulin Preparation Products And Raw materials
Raw materials
Preparation Products
Indibulin Suppliers
- Tel
- --
- Fax
- --
- contact@ambinter.com
- Country
- France
- ProdList
- 1648
- Advantage
- 60
View Lastest Price from Indibulin manufacturers
- Product
- 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide 204205-90-3
- Price
- US $9.80-8.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99.99%
- Supply Ability
- 10 MT/ Month
- Release date
- 2020-10-28
- Product
- 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide 204205-90-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30