4-Hydroxymethyl-1H-indazole

Product Name: 4-Hydroxymethyl-1H-indazole
CAS No.: 709608-85-5
Chemical Name: 4-Hydroxymethyl-1H-indazole
Synonyms: (1H-Indazol-4-yl);1H-INDAZOLE-4-METHANOL;(1H-indazol-4-yl)methanol;4-Hydroxymethyl-1H-indazole
CBNumber: CB12129287
Molecular Formula: C8H8N2O
Formula Weight: 148.16
MOL File: 709608-85-5.mol

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4-Hydroxymethyl-1H-indazole Property

Boiling point:: 380.3±17.0 °C(Predicted)
Density: 1.360±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 13.92±0.40(Predicted)
color: Grey to beige to brown
CAS DataBase Reference: 709608-85-5

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: Y5530
Product name: 4-(Hydroxymethyl)-1H-indazole
Packaging: 1g
Price: $131
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-1-09
Product name: 1H-Indazole-4-methanol
Purity: 97%
Packaging: 1g
Price: $71
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-1-09
Product name: 1H-Indazole-4-methanol
Purity: 97%
Packaging: 5G
Price: $215
Updated: 2021/12/16

Matrix Scientific

Product number: 132398
Product name: (1H-Indazol-4-yl)methanol
Purity: 97%
Packaging: 5g
Price: $580
Updated: 2021/12/16

Matrix Scientific

Product number: 132398
Product name: (1H-Indazol-4-yl)methanol
Purity: 97%
Packaging: 25g
Price: $1625
Updated: 2021/12/16

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4-Hydroxymethyl-1H-indazole Chemical Properties,Usage,Production

Synthesis

192945-49-6

709608-85-5

General procedure for the synthesis of 4-(hydroxymethyl)-1H-indazole from methyl indazole-4-carboxylate: synthesis of (1H-indazol-4-yl)-methanol (18b): the ester obtained above (40 mg, 0.23 mmol) was dissolved in 1 mL of tetrahydrofuran (THF) and the solution was cooled to 0°C. A THF solution (1.0 M, 2.3 mL, 2.3 mmol) of diisobutylaluminum hydride (DIBAL) was added slowly and dropwise. The addition of DIBAL was continued until the feedstock was completely consumed. Upon completion of the reaction, the reaction was quenched with saturated sodium potassium tartrate solution and gradually warmed to room temperature. The reaction mixture was extracted using ethyl acetate. The organic phases were combined and dried with anhydrous magnesium sulfate (MgSO4). Subsequently, the solvent was removed by reduced pressure distillation and the residue was purified by column chromatography (75% ethyl acetate/hexane). The final target product (20 mg, 60% yield) was obtained as a white solid. Mass spectrometry (electrospray ionization) analysis showed that the theoretical value of M + H = 149.1 and the measured value = 149.1.

References

[1] Patent: WO2007/51062, 2007, A2. Location in patent: Page/Page column 126-127

4-Hydroxymethyl-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxymethyl-1H-indazole Suppliers

China 65 India 1 United Kingdom 2 United States 8 Global 76

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View Lastest Price from 4-Hydroxymethyl-1H-indazole manufacturers

Career Henan Chemical Co

Product: 4-Hydroxymethyl-1H-indazole 709608-85-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2019-12-30

709608-85-5, 4-Hydroxymethyl-1H-indazoleRelated Search:

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4-Hydroxymethyl-1H-indazole

1H-INDAZOLE-4-METHANOL

(1H-indazol-4-yl)methanol

(1H-Indazol-4-yl)

709608-85-5

Building Blocks

Indazole