ChemicalBook > CAS DataBase List > (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

Product Name: (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE
CAS No.: 131685-53-5
Chemical Name: (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE
Synonyms: (R)-3-(1-Oxopropyl)-4-b;R-4-Benzyl-3-Propiony-2-Oxazolidinone;N-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE;(R)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE;(-)-4-Benzyl-3-propionyl-2-oxazolidinone;(R)-4-benzy1-3-propionyloxazolidin-2-one;(4R)-4-Benzyl-3-propionyloxazolidin-2-one;N-3-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE;(4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2;(R)-(-)-4-Benzyl-3-propiomyl-2-oxazolidinone
CBNumber: CB1217072
Molecular Formula: C13H15NO3
Formula Weight: 233.26
MOL File: 131685-53-5.mol

Less

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Property

Melting point:: 45 °C
Boiling point:: 396.6±11.0 °C(Predicted)
Density: 1.206±0.06 g/cm3(Predicted)
refractive index: -103 ° (C=1, EtOH)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, Ethanol
pka: -2.35±0.40(Predicted)
form: Solid
color: Off-White
optical activity: [α]20/D 102°, c = 1 in ethanol
InChI: InChI=1S/C13H15NO3/c1-2-12(15)14-11(9-17-13(14)16)8-10-6-4-3-5-7-10/h3-7,11H,2,8-9H2,1H3/t11-/m1/s1
InChIKey: WHOBYFHKONUTMW-LLVKDONJSA-N
SMILES: O1C[C@@H](CC2=CC=CC=C2)N(C(=O)CC)C1=O
CAS DataBase Reference: 131685-53-5(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
HS Code: 29349990

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 459542
Product name: (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: 99%
Packaging: 1g
Price: $54.2
Updated: 2023/01/07

Sigma-Aldrich

Product number: 459542
Product name: (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: 99%
Packaging: 5g
Price: $224
Updated: 2023/01/07

TCI Chemical

Product number: B2165
Product name: (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: >98.0%(GC)
Packaging: 1g
Price: $79
Updated: 2025/07/31

TCI Chemical

Product number: B2165
Product name: (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: >98.0%(GC)
Packaging: 5g
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: 459542
Product name: (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: 99%
Packaging: 25g
Price: $1090
Updated: 2023/06/20

Less

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone can be used as a building block for the preparation of methyl 3-[(S)-3-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-methyl-3-oxopropyl]benzoate by treating with strong base followed by the addition of methyl 3-bromomethyl benzoate.

Uses

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE is a oxazolidinone derivative used in the preparation of anisomycin analogues as activators of the JNK/SAPK1 and p38/SAPK2 pathways.

General Description

(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone is used as a building block in organic synthesis for the preparation of oxazolidinone derivatives.

Synthesis

90719-32-7

79-03-8

131685-53-5

Under nitrogen protection, (S)-4-benzyl-2-azolidinone (800 mg, 4.5 mmol) was dissolved in a dry reaction vial of anhydrous tetrahydrofuran (30 mL) and cooled to -78 °C in a dry ice/acetone bath. A hexane solution of 1.6 M n-butyllithium (5.0 mmol, 3.1 mL) was added slowly and dropwise over 3 min. After stirring for 30 min, propionyl chloride (5.0 mmol, 0.43 mL) was added slowly over 3 min. The reaction solution was slowly warmed to room temperature over 14 h. The reaction was subsequently quenched by the addition of saturated ammonium chloride solution (10 mL) and water (30 mL). The aqueous layer was extracted with ethyl acetate (3 x 40 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure to afford (R)-(-)-benzyl-3-propionyl-2-oxazolidinone (oil, 1.0 g, 96% yield) with >95% purity by HPLC.1H NMR (500 MHz, CDCl3): δ 7.33 (dd, J1 = 7.4 Hz, J2 = 7.6 Hz, 2H), 7.29 (d, J = 6.9 Hz, 1H) ), 7.21 (d, J = 7.4 Hz, 2H), 4.67 (m, 1H), 4.18 (m, 2H), 3.31 (dd, J1 = 13.3 Hz, J2 = 3.2 Hz, 1H), 2.96 (m, 2H), 2.77 (dd, J1 = 13.3 Hz, J2 = 3.7 Hz, 1H), 1.21 (t, J = 7.4 Hz, 1H). 3H).

References

[1] Chemistry - An Asian Journal, 2011, vol. 6, # 7, p. 1791 - 1799
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 144 - 148
[3] Journal of Organic Chemistry, 2008, vol. 73, # 8, p. 3292 - 3294
[4] Angewandte Chemie - International Edition, 2016, vol. 55, # 13, p. 4252 - 4255
[5] Angew. Chem., 2016, vol. 128, # 13, p. 4324 - 4327,4

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Suppliers

Americas 1 Canada 1 China 151 Europe 3 France 1 Germany 2 India 5 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 12 United States 34 Global 213

Changzhou PBpharmaceutical R&D Co.,Ltd

Tel: 086-0519-83990708 18915800124
Fax: 0519-83990708
Email: info@pbpharm.com
Country: China
ProdList: 487
Advantage: 55

Shanghai Leto Pharmatech Co.,Ltd.

Tel: 18016401466
Fax: QQ: 1375988926
Email: sales@letopharm.com
Country: China
ProdList: 245
Advantage: 58

Shang Hai Muse Health Tech Co., Ltd.

Tel: 021-021-61069951-8018 13262285760
Email: xul@musehealthtech.com
Country: China
ProdList: 178
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Aemon Chemical

Tel: 0086-755-86198205
Email: acinfo@aemonchem.com
Country: China
ProdList: 1931
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Wuhan Haizheng Industry & Trade Development Co. Ltd

Tel: 027-8866 0053/88660577/88660578
Fax: 027-8899 1911
Country: China
ProdList: 1073
Advantage: 55

Tianjin Derchemist Science & Technology Co., Ltd.

Tel: 22-58627059 13920586291
Fax: 022-58620305
Email: zdcomcon@126.com
Country: China
ProdList: 3829
Advantage: 50

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Letopharm Limited

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 70
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Nanjing Credit Trading Co.,Ltd

Tel: 025-52164950
Fax: 025-86800069
Email: Googlexu_0114@sina.com
Country: China
ProdList: 644
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

Shanghai Jovan Biochemical Technology Co. Ltd.

Tel: +86-021-61654350
Fax: +86-021-61654350
Email: 1245958370@qq.com
Country: China
ProdList: 2982
Advantage: 50

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 4053
Advantage: 60

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

Nanjing Huang Tai Pharmaceutical Technology Co. Ltd.

Tel: 025-58803135 18551845925
Fax: 025-58803650
Email: 3569572487@qq.com
Country: China
ProdList: 337
Advantage: 58

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6468
Advantage: 55

Shanghai Chiral bio-compound co., Ltd.

Tel: 021-5068 3667/17749785980/1029026415; 17749785980
Fax: 021-50683667
Email: 1029026415@qq.com
Country: China
ProdList: 3397
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9021
Advantage: 60

Less

View Lastest Price from (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-4-benzy1-3-propionyloxazolidin-2-one 131685-53-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 131685-53-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 131685-53-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-07-03

131685-53-5, (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONERelated Search:

(4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE (R)-4-BENZYL-3-(3-CYCLOPROPYL-PROPIONYL)-OXAZOLIDIN-2-ONE (R)-4-BENZYL-3-(4-METHYL-PENTANOYL)-OXAZOLIDIN-2-ONE (3S,4R)-4-BENZYL-3-(3-METHYLPENTANOYL)-OXAZOLIDIN-2-ONE 3-[(4-METHOXYPHENYL)ACETYL]-(4R)-(PHENYLMETHYL)-2-OXAZOLIDINONE 3-(2-PHENYLACETYL)-(4R)-(PHENYLMETHYL)-2-OXAZOLIDINONE 3-(4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-hexanoic acid tert-butyl ester (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one (R)-4-BENZYL-3-(3-CYCLOPENTYL-PROPIONYL)-OXAZOLIDIN-2-ONE

(R)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

N-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE

N-3-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE

(R)-(-)-4-Benzyl-3-propiomyl-2-oxazolidinone

(4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2-one

(-)-4-Benzyl-3-propionyl-2-oxazolidinone

(4R)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one

(4R)-4-Benzyl-3-propionyloxazolidin-2-one

(R)-3-(1-Oxopropyl)-4-(phenylMethyl)-2-oxazolidinone

(R)-3-(1-Oxopropyl)-4-b

R-4-Benzyl-3-Propiony-2-Oxazolidinone

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone≥ 99% (HPLC)

(R)-4-Benzyl-3-propionyl-2-oxazolidinone,99%e.e.

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

(4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone, ee: 99%

(R)-4-Benzyl-3-propionyloxazolidin-2-one 97%

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone &gt

2-Oxazolidinone, 3-(1-oxopropyl)-4-(phenylmethyl)-, (4R)-

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE USP/EP/BP

(R)-4-benzy1-3-propionyloxazolidin-2-one

(R)-4-benzyl-3-propionyloxazolidin-2-one 99.72%( (R)?-?(-?)?-?4-?Benzyl-?3-?propionyl-?2-?oxazolidinone)

(<i>R</i>)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone

131685-53-5

Chiral Building Blocks

Asymmetric Synthesis

Glycidyl Compounds, etc. (Chiral)

Oxazolidinone Derivatives

Chiral Auxiliaries

Aromatics

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Oxazolidinone

chiral

Asymmetric Synthesis

Chiral Building Blocks

Glycidyl Compounds, etc. (Chiral)

Synthetic Organic Chemistry

Peptide

Asymmetric Synthesis

Chiral Auxiliaries

Oxazolidinone Derivatives