(4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone

Product Name: (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone
CAS No.: 101711-78-8
Chemical Name: (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone
Synonyms: 4-benzyl-3-propionyloxazolidin-2-one;-3-propionyL;(S)-N-Propionyl-4-benzyl-1;S-4-Benzyl-3-Propiony-2-Oxazolidinone;N-PROPIONYL-(4S)-BENZYL-2-OXAZOLIDINONE;(S)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE;N-3-PROPIONYL-(4S)-BENZYL-2-OXAZOLIDINONE;(4S)-4-Benzyl-3-propanoyloxazolidin-2-one;(S)-(+)-4-Benzyl-3-propiomyl-2-oxazolidin;(S)-(+)-4-BENZYL-3-PROPIONYL-2-OXALIDINONE
CBNumber: CB6247465
Molecular Formula: C13H15NO3
Formula Weight: 233.26
MOL File: 101711-78-8.mol

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(4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone Property

Melting point:: 42-44 °C
alpha: 97 º (c=1, EtOH)
Boiling point:: 375.51°C (rough estimate)
Density: 1.1475 (rough estimate)
refractive index: 103 ° (C=1, EtOH)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, Methanol
form: Solid
pka: -2.35±0.40(Predicted)
color: Off-White to Pale Yellow
optical activity: [α]20/D +97°, c = 1 in ethanol
InChI: InChI=1S/C13H15NO3/c1-2-12(15)14-11(9-17-13(14)16)8-10-6-4-3-5-7-10/h3-7,11H,2,8-9H2,1H3/t11-/m0/s1
InChIKey: WHOBYFHKONUTMW-NSHDSACASA-N
SMILES: O1C[C@H](CC2=CC=CC=C2)N(C(=O)CC)C1=O
CAS DataBase Reference: 101711-78-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22-43
Safety Statements: 37/39-26-36-36/37
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 458775
Product name: (S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: 99%
Packaging: 5g
Price: $123
Updated: 2025/07/31

TCI Chemical

Product number: B2166
Product name: (S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: >96.0%(GC)
Packaging: 1g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: B2166
Product name: (S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: >96.0%(GC)
Packaging: 5g
Price: $124
Updated: 2025/07/31

TRC

Product number: B288650
Product name: (S)-4-Benzyl-3-propionyl-2-oxazolidinone
Packaging: 2.5g
Price: $150
Updated: 2021/12/16

Chem-Impex

Product number: 23187
Product name: (S)-4-Benzyl-3-propionyl-2-oxazolidinone,≥99%(HPLC)
Purity: ≥99%(HPLC)
Packaging: 25G
Price: $145.6
Updated: 2021/12/16

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(4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone Chemical Properties,Usage,Production

Chemical Properties

Colourless Solid

Uses

Versatile chiral auxiliary for asymmetric synthesis.

Uses

Intermediate in the preparation of Albaconazole.

Synthesis

90719-32-7

79-03-8

131685-53-5

Under nitrogen atmosphere, (S)-4-benzyl-2-azolidinone (800 mg, 4.5 mmol) was dissolved in a dry reaction vial of anhydrous tetrahydrofuran (30 mL) and cooled to -78 °C in a dry ice/acetone bath. A hexane solution of 1.6 M n-butyllithium (5.0 mmol, 3.1 mL) was added slowly and dropwise over 3 min. After stirring for 30 min, propionyl chloride (5.0 mmol, 0.43 mL) was added dropwise over 3 min. The reaction solution was slowly warmed to room temperature over 14 h. The reaction was subsequently quenched by the addition of saturated ammonium chloride solution (10 mL) and water (30 mL). The aqueous layer was extracted with ethyl acetate (3 x 40 mL), the organic phases were combined and dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford (R)-(-)-benzyl-3-propionyl-2-oxazolidinone (oil, 1.0 g, 96% yield) with >95% purity by HPLC.1H NMR (500 MHz, CDCl3): δ7.33 (dd, J1=7.4 Hz, J2=7.6 Hz, 2H), 7.29 (d, J=6.9 Hz, 1H), 7.21 (d, J=7.4 Hz, 2H), 4.67 (m, 1H), 4.18 (m, 2H), 3.31 (dd, J1=13.3 Hz, J2=3.2 Hz, 1H), 2.96 (m, 2H), 2.77 (dd, J1=13.3 Hz, J2=3.7 Hz, 1H), 1.21 (t, J=7.4 Hz, 3H).

References

[1] Chemistry - An Asian Journal, 2011, vol. 6, # 7, p. 1791 - 1799
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 144 - 148
[3] Journal of Organic Chemistry, 2008, vol. 73, # 8, p. 3292 - 3294
[4] Angewandte Chemie - International Edition, 2016, vol. 55, # 13, p. 4252 - 4255
[5] Angew. Chem., 2016, vol. 128, # 13, p. 4324 - 4327,4

(4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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(4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone Suppliers

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View Lastest Price from (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone manufacturers

RongNa Biotechnology Co.,Ltd

Product: (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone 101711-78-8
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-08-27

Shaanxi Dideu New Materials Co. Ltd

Product: (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone 101711-78-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-07-05

Henan Aochuang Chemical Co.,Ltd.

Product: (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone 101711-78-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-19

101711-78-8, (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinoneRelated Search:

Allicin (4S)-4-Methyl-2-oxazolidinone (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole 2-Oxazolidone (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE,(R)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 3-[(4-CHLOROPHENYL)ACETYL]-(4S)-(PHENYLMETHYL)-2-OXAZOLIDINONE (S)-4-BENZYL-3-(2-P-TOLYLACETYL)OXAZOLIDIN-2-ONE (S)-3-(5-CHLOROPENTANOYL)-4-BENZYLOXAZOLIDIN-2-ONE (3S,4S)-4-BENZYL-3-(3-METHYLPENTANOYL)-OXAZOLIDIN-2-ONE 4-Benzyl-3-(5-chloro-2-isopropyl-pent-4-enoyl)-oxazolidin-2-one 3-(1-OXO-2-PHENYLETHYL)-4(S)-(PHENYLMETHYL)-2-OXAZOLIDINONE (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone (4S)-3-BUTYRYL-4-BENZYL-2-OXAZOLIDINONE 4-Benzyl-3-(3-methyl-butyryl)-oxazolidin-2-one (S)-4-Benzyl-3-[2-(4-methoxyphenyl)acetyl]-2-oxazolidinone

N-PROPIONYL-(4S)-BENZYL-2-OXAZOLIDINONE

N-3-PROPIONYL-(4S)-BENZYL-2-OXAZOLIDINONE

(S)-(+)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

(S)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

(S)-(+)-4-BENZYL-3-PROPIONYL-2-OXALIDINONE

(S)-(+)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDI N-ONE, 99% (99% EE/HPLC)

(4s)-(+)-benzyl-3-propionyl-2-oxazolidinone

(S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone,99%

(4S)-(+)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

(S)-(+)-4-Benzyl-3-propiomyl-2-oxazolidinone

(4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone,97%

(4S)-4-Benzyl-2-oxo-3-propanoyl-1,3-oxazolidine

(4S)-4-Benzyl-3-propanoyl-1,3-oxazolidin-2-one

(4S)-3-(1-Oxopropyl)-4-(phenylMethyl)-2-oxazolidinone

(4S)-4-Benzyl-3-propanoyloxazolidin-2-one

(4S)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one

(S)-N-Propionyl-4-benzyl-1

S-4-Benzyl-3-Propiony-2-Oxazolidinone

4-benzyl-3-propionyloxazolidin-2-one

(S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone 99%

(S)-4-Benzyl-3-propionyl-2-oxazolidinone,99%e.e.

(S)-(+)-4-Benzyl-3-propiomyl-2-oxazolidin

(S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone &gt

-3-propionyL

2-Oxazolidinone, 3-(1-oxopropyl)-4-(phenylmethyl)-, (4S)-

(4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone USP/EP/BP

(<i>S</i>)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone

101711-78-8

101711-53-5

101711-78-5

C13H15NO3

Chiral Auxiliaries

Glycidyl Compounds, etc. (Chiral)

Chiral Building Blocks

Asymmetric Synthesis

Oxazolidinone Derivatives

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Asymmetric Synthesis

Chiral Auxiliaries

Oxazolidinone Derivatives

Aromatics

Oxazolidinone

API intermediates

Asymmetric Synthesis

Chiral Building Blocks

Glycidyl Compounds, etc. (Chiral)

Synthetic Organic Chemistry

Peptide