Hydrocortisone-17-butyrate
- Product Name
- Hydrocortisone-17-butyrate
- CAS No.
- 13609-67-1
- Chemical Name
- Hydrocortisone-17-butyrate
- Synonyms
- HYDROCORTISONE BUTYRATE;HYDROCORTISONE 17-BUTYRATE;Alfason;h.17b;locoid;Plancol;Laticort;hb(sub17);Nicotine Impurity 8;CORTISOL 17-BUTYRATE
- CBNumber
- CB1230781
- Molecular Formula
- C25H36O6
- Formula Weight
- 432.56
- MOL File
- 13609-67-1.mol
Hydrocortisone-17-butyrate Property
- Melting point:
- 210.0 to 214.0 °C
- Boiling point:
- 466.2°C (rough estimate)
- Density
- 1.0914 (rough estimate)
- refractive index
- 1.4593 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.98±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Merck
- 14,4787
- InChIKey
- BMCQMVFGOVHVNG-IZBZUILHNA-N
- SMILES
- O([C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)C(=O)CO)C(=O)CCC |&1:1,4,6,16,18,20,23,r|
- CAS DataBase Reference
- 13609-67-1(CAS DataBase Reference)
Safety
- WGK Germany
- 2
- RTECS
- GM9002000
- HS Code
- 2937290000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- H5270
- Product name
- Hydrocortisone 17-butyrate
- Packaging
- 1g
- Price
- $132
- Updated
- 2024/03/01
- Product number
- 1317302
- Product name
- Hydrocortisone butyrate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- H1506
- Product name
- Hydrocortisone 17-Butyrate
- Purity
- >98.0%(HPLC)
- Packaging
- 200mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- H1506
- Product name
- Hydrocortisone 17-Butyrate
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $125
- Updated
- 2024/03/01
- Product number
- H714605
- Product name
- Hydrocortisone butyrate
- Packaging
- 2.5g
- Price
- $160
- Updated
- 2021/12/16
Hydrocortisone-17-butyrate Chemical Properties,Usage,Production
Description
Hydrocortisone 17-butyrate: a new non-fluorinated topical corticosteroid.
Hydrocortisone 17-butyrate could be used in psoriasis, eczema and other inflammatory dermatoses. It may be found in creams, lotions, ointments, and powders and in ear, nose and eye drops for rhinitis, otitis, and conjunctivitis. In double-blind paired comparisons with other topical corticosteroids, the efficacy of hydrocortisone 17-butyrate 0.1% has generally been indistinguishable from that of triamcinolone acetonide 0.1%, fluocinolone acetonide 0.025% or betamethasone 17-valerate 0.1% in patients with eczema or psoriasis. When applied to the face of patients with atrophy superimposed on rosacea and perioral dermatitis resulting from prolonged use of fluorinated topical corticosteroids, hydrocortisone 17-butyrate 0.1% did not prevent the beneficial effect of systemic tetracycline nor the disappearance of telangiectasis and tended to be more effective than hydrocortisone 1%[1].
Uses
Hydrocortisone Butyrate is a topical corticosteroid use to treat a variety of dermatological conditions. It acts as an antiinflammatory, antiproliferative and immunosuppresive agent.
Uses
antineoplastic
Uses
Hydrocortisone-17-butyrate is a topical corticosteroid with anti-inflammatory properties; marker for topical corticosteroid allergy.
Definition
ChEBI: Cortisol esterified with butyric acid at the 17-hydroxy group.
brand name
Locoid (Ferndale); Locoid (Yamanouchi).
Contact allergens
Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti- sone. It represents the D2 group of corticosteroids, non C 16 methylated with a C 17 ester: hydrocortisone 17-butyrate, hydrocortisone 17-valerate, hydrocortisone aceponate (17-propionate and 21-acetate), methylpred- nisolone aceponate, and prednicarbate. It is sometimes hydrolyzed in vivo into hydrocortisone, giving allergic reactions to group-A-sensitized people.
Biochem/physiol Actions
Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.
References
[1] R N Brogden. “Hydrocortisone 17-butyrate: a new topical corticosteroid preliminary report.” ACS Chemical Neuroscience 12 4 (1976): 249–57.
Hydrocortisone-17-butyrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Hydrocortisone-17-butyrate manufacturers
- Product
- Hydrocortisone-17-butyrate 13609-67-1
- Price
- US $20.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20
- Release date
- 2024-03-20
- Product
- Hydrocortisone 17-butyrate 13609-67-1
- Price
- US $9.00-60.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-03-22
- Product
- Hydrocortisone-17-butyrate 13609-67-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11