Description Biological functions Synthesis
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FMRF AMIDE

Description Biological functions Synthesis
Product Name
FMRF AMIDE
CAS No.
64190-70-1
Chemical Name
FMRF AMIDE
Synonyms
FMRF-NH2;MFRF amide;FMRF AMIDE;neuropeptide C;PHE-MET-ARG-PHE-NH2;PHE-MET-ARG-PHE AMIDE;H-PHE-MET-ARG-PHE-NH2;L-Phe-L-Met-L-Arg-Phe-NH2;FMRF-AMIDE 1 1/2ACOH 2H2O;L-Phe-L-Met-L-Arg-L-Phe-NH2
CBNumber
CB1231122
Molecular Formula
C29H42N8O4S
Formula Weight
598.76
MOL File
64190-70-1.mol
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FMRF AMIDE Property

Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble in DMSO
pka
13.35±0.46(Predicted)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
F5600-05F
Product name
FMRF amide
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
F5600-05
Product name
FMRF amide
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
F5600-05H
Product name
FMRF amide
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
F5600-05J
Product name
FMRF amide
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
F5600-05K
Product name
FMRF amide
Packaging
1mg
Price
$531
Updated
2021/12/16
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FMRF AMIDE Chemical Properties,Usage,Production

Description

FMRFamide (FMRFa) was originally isolated as a cardioacceleratory peptide from mollusks. To date, a number of biologically active FMRFas and their related peptides have been identified. 

Biological functions

Target cells and function The predominant effect of FaRPs is the reduction of spontaneous muscle contractions, such as in the intestinal muscle and the heart rate. Among FaRP subtypes, some FaRPs function in gut contraction and other subtypes do not. Physiological discrimination according to different subtype of FaRPs results in extensive functions.For example, FaRPs exert acceleratory effects on the heart rate, inhibitory effects on gut motility, and modulate synaptic activity. Furthermore, sequential ecdysis behavior is also regulated by FaRPs, consequently activating the downstream of the eclosion hormone (EH) and ecdysistriggering hormone (ETH).During ecdysis, FaRP-expressing Tv neurons are activated by ETH.

Synthesis

Gene, mRNA, and precursor D. melanogaster FMRFa mRNA produces a deduced prepropeptide composed of 347 aa. The prepropeptide is composed of a signal sequence, and 10 copies of FMRFa and extended FaRPs. The mature peptides are processed proteolytically and amidated at each C-terminal of the peptides.

FMRF AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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FMRF AMIDE Suppliers

China 15 France 1 Germany 3 Japan 2 Switzerland 1 United Kingdom 3 United States 13 USA 1 Global 39
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
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China
ProdList
15839
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MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
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United States
ProdList
4861
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58
Watson Biotechnology Co.,Ltd
Tel
027-59207879 1972026995 18140587686
Fax
QQ：1972026995
Email
sales@3600chem.com
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China
ProdList
4675
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55
Creative Peptides
Tel
Email
info@creative-peptides.com
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United States
ProdList
6083
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56
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
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55
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6756
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58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
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China
ProdList
52693
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58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
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China
ProdList
9729
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58
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
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United States
ProdList
19741
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58
Ontores Biotech
Tel
0571-88760729 18072970094
Email
supports@ontorespeptide.com
Country
China
ProdList
2696
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58

64190-70-1, FMRF AMIDERelated Search:

[D-MET2]-FMRF-AMIDE FMRF amide (AF-1) (Lys-Asn-Glu-Phe-Ile-Arg-Phe-NH2) FMRF amide (AF-2) (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) FMRF amide (Phe-Met-Arg-Phe-NH2) (Molluscan Cardioexcitatory Neuropeptide) FMRF amide [D-Phe1] (D-Phe-Met-Arg-Phe-NH2) FMRF amide [D-Met2] (Phe-D-Met-Arg-Phe-NH2) FMRF amide-like Peptide I (lobster) (Ser-Asp-Arg-Asn-Phe-Leu-Arg-Phe-NH2) FMRF AMIDE MOLLUSCAN CARDIOEXCITATORY PEPTIDE,FMRF-AMIDE 1 1/2ACOH 2H2O,FMRF AMIDE FMRF AMIDE-LIKE PEPTIDE II, LOBSTER FMRF amide [D-Arg3] (Phe-Met-D-Arg-Phe-NH2) FMRF amide [D-Phe4] (Phe-Met-Arg-D-Phe-NH2) FMRF-AMIDE LIKE PEPTIDE 1 (LOBSTER),FMRF AMIDE-LIKE PEPTIDE I, LOBSTER FMRF amide (Nle-Arg-Phe-NH2) FMRF amide (Leu-Ser-Ser-Phe-Val-Arg-Ile-NH2) FMRF amide (Phe-Leu-Arg-Arg) FMRF amide (Tyr-Phe-Met-Arg-Phe-NH2) FMRF amide (Trp-Nle-Arg-Phe-NH2) FMRF amide (Met-Arg-Phe)

  • MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE
  • MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE 1 1/2 ACOH 2H2O
  • MOLLUSCAN CARDIOEXCITATORY PEPTIDE
  • PHE-MET-ARG-PHE AMIDE
  • PHE-MET-ARG-PHE-NH2
  • PHE-MET-ARG-PHE-NH2 1/2ACOH 2H2O
  • 6-O-?D-Glucopyranosyl-D-glucitol
  • L-PHENYLALANYL-L-METHIONYL-L-ARGINYL-L-PHENYLALANINAMIDE)
  • neuropeptide C
  • FMRF amide, Molluscan cardioexcitatory neuropeptide
  • L-Phe-L-Met-L-Arg-L-Phe-NH2
  • L-Phe-L-Met-L-Arg-Phe-NH2
  • MFRF amide
  • (2S)-N-[(1S)-2-amino-1-(benzyl)-2-keto-ethyl]-2-[[2-[[(2S)-2-amino-3-phenyl-propanoyl]amino]-4-(methylthio)butanoyl]amino]-5-guanidino-valeramide
  • (2S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-(diaminomethylideneamino)pentanamide
  • (2S)-N-[(2S)-1-azanyl-1-oxo-3-phenyl-propan-2-yl]-2-[[2-[[(2S)-2-azanyl-3-phenyl-propanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-5-[bis(azanyl)methylideneamino]pentanamide
  • Cardioexcitatory peptide (mollusk)
  • Neuropeptide C (Macrocallista nimbosa cardioexcitatory)
  • FMRF AMIDE
  • FMRF-AMIDE 1 1/2ACOH 2H2O
  • FMRF AMIDE MOLLUSCAN CARDIOEXCITATORY PEPTIDE
  • FMRF-NH2
  • H-PHE-MET-ARG-PHE-NH2
  • Phe-Met-Arg-Phe amide, ≥95% (HPLC)
  • L-Phenylalaninamide,L-phenylalanyl-L-methionyl-L-arginyl-
  • (S)-N-((S)-1-Amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((S)-2-amino-3-phenylpropanamido)-4-(methylthio)butanamido)-5-guanidinopentanamide
  • 64190-70-1
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • Other Neuropeptides
  • Peptides
  • Invertebrate Neuropeptides