ChemicalBook > CAS DataBase List > EHNA HYDROCHLORIDE

EHNA HYDROCHLORIDE

Product Name: EHNA HYDROCHLORIDE
CAS No.: 51350-19-7
Chemical Name: EHNA HYDROCHLORIDE
Synonyms: EHNA;EHNA HCL;NSC-263165;MEP1 HYDROCHLORIDE;EHNA HYDROCHLORIDE;9-erythro-(2-Hydroxyl-3-nonyl)adenine;(+)-erythro-9-(2-Hydroxy-3-nonyl)adenine;ERYTHRO-9-(2-HYDROXY-3-NONYL)ADENINE, HCL;ERYTHRO-9-(2-HYDROXY-3-NONYL)ADENINE HYDROCHLORIDE;9-erythro-(2-Hydroxy-3-nonyl)-adenine hydrochloride
CBNumber: CB1233267
Molecular Formula: C14H23N5O
Formula Weight: 277.37
MOL File: 51350-19-7.mol

Less

EHNA HYDROCHLORIDE Property

Melting point:: 183～184℃
storage temp.: 0-6°C
solubility: DMSO: 12 mg/mL
form: solid
color: white
Water Solubility: water: 25mg/mL
Stability:: Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 51350-19-7

Less

Safety

WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 324630
Product name: EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem
Packaging: 10mg
Price: $102
Updated: 2025/07/31

Tocris

Product number: 1261
Product name: EHNA hydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $389
Updated: 2021/12/16

Tocris

Product number: 1261
Product name: EHNA hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $97
Updated: 2021/12/16

TRC

Product number: H825590
Product name: 9-Erythro-(2-Hydroxyl-3-nonyl)adenine
Packaging: 25mg
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 366880
Product name: EHNA Hydrochloride
Packaging: 25mg
Price: $336
Updated: 2021/12/16

Less

EHNA HYDROCHLORIDE Chemical Properties,Usage,Production

Description

EHNA (51350-19-7) inhibits phosphodiesterase 2 (PDE2) (IC50 = 0.8 – 5.5 μM in a variety of tissues and species) over PDE1, PDE3, or PDE4 (IC50 values > 100 μM).1,2 It also inhibits adenosine deaminase (ADA), IC50 = 1.2 and 1.5 μM in human RBCs and astrocytoma cells, respectively3, which may be responsible for its ability to induce apoptosis in malignant pleural mesothelioma cell lines4. Because it blocks breakdown of adenosine to inosine and hypoxanthine, EHNA prevents formation of free radical substrates, protecting against cardiac reperfusion-mediated injury.5 It inhibits differentiation and maintains expression of pluripotency markers in hESCs, but not through inhibition of PDEs or ADA.6

Chemical Properties

White Solid

Uses

A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM)

Uses

9-erythro-(2-Hydroxyl-3-nonyl)adenine is an intermediate in the synthesis of potent inhibitor of phosphodiesterase II.

Definition

ChEBI: (2R,3S)-EHNA is eHNA of absolute configuration 2R,3S. Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. It has a role as an EC 3.5.4.4 (adenosine deaminase) inhibitor and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor. It is a conjugate base of a (2R,3S)-EHNA(1+). It is an enantiomer of a (2S,3R)-EHNA.

Biological Activity

Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC 50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase.

References

[1] THOMAS PODZUWEIT Antje M Peter Nennstiel. Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine[J]. Cellular signalling, 1995, 7 7: Pages 733-738. DOI:10.1016/0898-6568(95)00042-n
[2] P F MÉRY. Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes.[J]. Molecular Pharmacology, 1995, 48 1: 121-130.
[3] J BARANKIEWICZ. Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors.[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 283 3: 1230-1238.
[4] YASUHIRO NAKAJIMA. Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma.[J]. Cellular Physiology and Biochemistry, 2015: 51-60. DOI:10.1159/000369674
[5] ANWAR S. ABD-ELFATTAH PH.D. Andrew S W M D. Separation Between Ischemic and Reperfusion Injury by Site Specific Entrapment of Endogenous Adenosine and Inosine Using NBMPR and EHNA[J]. Journal of Cardiac Surgery, 1994, 9 3S: 387-396. DOI:10.1111/jocs.1994.9.3s.387
[6] PETER BURTON. Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.[J]. Biochemical Journal, 2010, 432 3: 575-584. DOI:10.1042/bj20100726

EHNA HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

EHNA HYDROCHLORIDE Suppliers

Canada 1 China 65 Germany 3 Japan 1 Switzerland 1 United Kingdom 5 United States 11 Global 87

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

NewCan Biotech Limited

Tel: +86-0571-86912261 +8613735419629
Email: sales@newcanbio.com
Country: China
ProdList: 9985
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18921922613
Email: hywu@aikonchem.com
Country: China
ProdList: 10709
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

Guangzhou Ruifeng Biotechnology Co., Ltd.

Tel: 14715141318
Country: CHINA
ProdList: 181
Advantage: 58

Guangzhou Qiansheng Biotechnology Co., Ltd.

Tel: 14748676110
Country: CHINA
ProdList: 112
Advantage: 58

Jinan Lemon Biotechnology Co., Ltd.

Tel: 138000000
Email: geans@163.com
Country: China
ProdList: 155
Advantage: 58

Xingwang Biotechnology Co., Ltd. (Ruijing Testing Company, please do not buy)

Tel: 15017521343
Country: CHINA
ProdList: 186
Advantage: 58

Guangzhou Sanxu Biotechnology Co., Ltd.

Tel: 15989179426
Country: CHINA
ProdList: 156
Advantage: 58

Aoki Biotechnology (Shenzhen) Co., Ltd.

Tel: 18566777408
Country: CHINA
ProdList: 156
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Beijing Sizhengbai Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: marketing@4abio.com
Country: CHINA
ProdList: 6401
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Shanghai Silk Dragon Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 3988
Advantage: 58

Hangzhou Lianke Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6349
Advantage: 58

Beijing Dakco is Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: bj_info@dakewe.net
Country: CHINA
ProdList: 6580
Advantage: 58

Shenzhen Branch Science and Technology Co., Ltd.

Tel: --
Fax: --
Email: zikerbio@163.com
Country: CHINA
ProdList: 6374
Advantage: 58

Beijing Zhijie Fangyuan Technology Co., Ltd.

Tel: --
Fax: --
Email: 15810200961@163.com
Country: CHINA
ProdList: 6643
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6793
Advantage: 58

Annuol (Beijing) Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: inquiry@annoron.com
Country: CHINA
ProdList: 6434
Advantage: 58

Boppard-China

Tel: --
Fax: --
Email: info@boppard.cn
Country: China
ProdList: 687
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6151
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6518
Advantage: 58

Beijing Anbiqi Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@abace-biology.com
Country: CHINA
ProdList: 2529
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

Qiyi Biotechnology (Shanghai) Co., Ltd.

Tel: --
Fax: --
Email: qiyibio@163.com
Country: CHINA
ProdList: 6241
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6757
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Shanghai Benrui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: john.st@163.com
Country: CHINA
ProdList: 2160
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Shanghai Yuda Industrial Co., Ltd.

Tel: --
Fax: --
Email: lucy@runwelltac.com
Country: CHINA
ProdList: 6448
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Shanghai Jijin Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jijinhuaxue@sina.com
Country: CHINA
ProdList: 6606
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: tech@chinabiovision.com
Country: CHINA
ProdList: 2731
Advantage: 58

51350-19-7, EHNA HYDROCHLORIDERelated Search:

ETAZOLATE BRL 50481 Vinpocetine ZAPRINAST ROLIPRAM Cilostazol (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE CILOSTAMIDE ZARDAVERINE RO 20-1724 Peroxidase 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Adenine hydrochloride hemihydrate Adenine hydrochloride Adenine Sulfate 1-Isopropylimidazole Adenine EHNA HYDROCHLORIDE

9-ERYTHRO-(2-HYDROXY-3-N-NONYL) ADENINE HYDROCHLORIDE

ERYTHRO-9-(2-HYDROXY-3-NONYL)ADENINE, HCL

ERYTHRO-9-(2-HYDROXY-3-NONYL)ADENINE HYDROCHLORIDE

ERYTHRO-9-AMINO-BETA-HEXYL-ALPHA-METHYL-9H-PURINE-9-ETHANOL HYDROCHLORIDE

EHNA

EHNA HCL

EHNA HYDROCHLORIDE

MEP1 HYDROCHLORIDE

ERYTHRO-9-(2-HYDROXY-3-NONYL)ADENINE, HC L POTENT INHIBITOR OF A

rac erythro-9-(2-Hydroxy-3-nonyl)adenine, Hydrochloride

9-erythro-(2-Hydroxy-3-nonyl)-adenine hydrochloride

NSC-263165

(+)-erythro-9-(2-Hydroxy-3-nonyl)adenine

(αS,βR)-6-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol

9-erythro-(2-Hydroxyl-3-nonyl)adenine

9H-Purine-9-ethanol, 6-amino-β-hexyl-α-methyl-, (αR,βS)-rel-

6-?amino-?β-?hexyl-?α-?methyl-?,(αR,?βS)?-?rel-9H-?Purine-?9-?ethanol

51350-19-7

C14H23N5OHCl

C14H24ClN5O

Adenosine deaminase inhibitor.

Bases & Related Reagents

Inhibitors

Nucleotides

Cyclic Nucleotide related

All Inhibitors