SUFUGOLIX
- Product Name
- SUFUGOLIX
- CAS No.
- 308831-61-0
- Chemical Name
- SUFUGOLIX
- Synonyms
- TAK013;SUFUGOLIX;tak-013, >98%;TAK013;TAK 013;SUFUGOLIX, >98%;Sufugolix(TAK-013);TAK 013,Inhibitor,Sufugolix,inhibit,TAK013;N-(4-(5-((benzyl(methyl)amino)methyl)-1-(2,6-difluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea;TAK-013 1-(4-(5-((benzyl(methyl)amino)methyl)-1-(2,6-difluorobenzyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea;Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[methyl(phenylmethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-
- CBNumber
- CB12451333
- Molecular Formula
- C36H31F2N5O4S
- Formula Weight
- 667.72
- MOL File
- 308831-61-0.mol
SUFUGOLIX Property
- Density
- 1.383±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- solubility
- DMF: 5mg/mL; DMF:PBS (pH 7.2) (1:2): 0.3mg/mL; DMSO: 3mg/mL
- form
- A solid
- pka
- 13.20±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27996
- Product name
- Sufugolix
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 27996
- Product name
- Sufugolix
- Packaging
- 10mg
- Price
- $223
- Updated
- 2024/03/01
- Product number
- 27996
- Product name
- Sufugolix
- Packaging
- 5mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 6280CJ
- Product name
- Sufugolix
- Packaging
- 5mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- BRS0000770
- Product name
- TAK-013
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $943.91
- Updated
- 2021/12/16
SUFUGOLIX Chemical Properties,Usage,Production
Description
Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM). Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM). Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.