ChemicalBook > CAS DataBase List > 2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE

2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE

Product Name: 2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE
CAS No.: 64874-38-0
Chemical Name: 2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE
Synonyms: 6-BROMO-1,8-NAPHTHYRIDIN-2-AMINE;2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE;1,8-Naphthyridin-2-amine, 6-bromo-;6-Bromo-1,8-naphthyridin-2-amine, 2-Amino-6-bromo-1,8-diazanaphthalene
CBNumber: CB12452774
Molecular Formula: C8H6BrN3
Formula Weight: 224.06
MOL File: 64874-38-0.mol

Less

2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE Property

Melting point:: 210-212 °C (sublm)
Boiling point:: 357.2±37.0 °C(Predicted)
Density: 1.744±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: solid
pka: 4.15±0.30(Predicted)
Appearance: Light yellow to orange Solid

Less

Safety

Risk Statements: 41
Safety Statements: 26-39
HS Code: 2902900000

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: B755180
Product name: 6-Bromo-1,8-naphthyridin-2-amine
Packaging: 500mg
Price: $285
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0143454
Product name: 2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE
Purity: 95.00%
Packaging: 250MG
Price: $332.85
Updated: 2021/12/16

AK Scientific

Product number: W7633
Product name: 2-Amino-6-bromo-1,8-naphthyridine
Packaging: 250mg
Price: $207
Updated: 2021/12/16

Apolloscientific

Product number: OR41142
Product name: 2-Amino-6-bromo-1,8-naphthyridine
Packaging: 250mg
Price: $240
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-9-51
Product name: 2-Amino-6-bromo-1,8-naphthyridine
Packaging: 250mg
Price: $264
Updated: 2021/12/16

Less

2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE Chemical Properties,Usage,Production

Uses

6-Bromo-1,8-naphthyridin-2-amine is used as a reactant in the preparation of substituted naphthyridines as H-PGDS inhibitors.

Synthesis

141-86-6

2065-75-0

64874-38-0

General procedure for the synthesis of 2-amino-6-bromo-1,8-naphthyridine from 2,6-diaminopyridine and 2-bromomalonaldehyde: 2,6-diaminopyridine (6.0 g, 55 mmol) and 2-bromo-1,3-malonaldehyde (8.0 g, 53 mmol) were dissolved in 85% orthophosphoric acid (160 mL) and heated and refluxed for 6 hours. Upon completion of the reaction, the reaction endpoint was confirmed by thin layer chromatography (TLC) monitoring. After cooling the reaction mixture to room temperature, it was neutralized with ammonia (NH4OH) solution to give a dark brown solid. After filtration and drying of this solid, it was dissolved in methanol (MeOH) with the aid of sonication. Purification by column chromatography afforded the light yellow solid product 2-amino-6-bromo-1,8-naphthyridine (3.85 g, 30.3% yield), which had an Rf value of 0.39 (unfolding reagent ratio CH2Cl2:MeOH = 10:1) and a melting point of 160-162°C (literature value 4: 210-212°C). The 1H NMR (500 MHz, DMSO-d6) data of the product were as follows: δ 7.82 (d, J = 2.6 Hz, 1H), 7.46 (d, J = 2.6 Hz, 1H), 7.04 (d, J = 8.8 Hz, 1H), 6.14 (s, 2H), 5.99 (d, J = 8.8 Hz, 1H).

References

[1] Heterocycles, 2015, vol. 91, # 5, p. 1001 - 1006

2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE Suppliers

China 49 India 1 Switzerland 1 United Kingdom 2 United States 7 Global 60

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Wuhan Greenkj Pharmaceutical Technology Co., Ltd.

Tel: 15608630565
Fax: -
Email: greenkjpharm@163.com
Country: China
ProdList: 130
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Wuxi AppTec

Tel: 022-59987777 13552403979
Email: jia_guoqiang@wuxiapptec.com
Country: China
ProdList: 22345
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9713
Advantage: 58

Shanghai HongMin Pharmaceutical Co., Ltd.

Tel: 13651987816
Fax: -
Email: hongminpharm@163.com
Country: China
ProdList: 2326
Advantage: 58

wuhan Dekray Biomedical Technology Co.,Ltd

Tel: 027-69573188 18221423799
Email: 1503407886@qq.com
Country: China
ProdList: 1439
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Shanghai Amico Chemicals Co. LTD

Tel: 微信 17321281695 18019252918
Fax: qq:1454668768
Email: 1454668768@qq.com
Country: China
ProdList: 14856
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Huansheng Meisen Pharmaceutical Technology (Shandong) Co., Ltd

Tel: 0531-88762217 18301471076
Email: sales@acespharma.com
Country: China
ProdList: 3863
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

Yuzhou Enthalpy Carbon Pharmaceutical Technology Co. LTD

Tel: 19963477321; 19963477321
Fax: QQ:2041275825
Email: 2041275825@qq.com
Country: China
ProdList: 1447
Advantage: 58

Shanghai Ruipu Medical Technology Co., Ltd

Tel: 15895968936
Fax: qq 1018762393
Email: 1018762393@qq.com
Country: China
ProdList: 9999
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Shandong Baiqi Biomedical Co. Ltd

Tel: 0536-8998390 13173160180
Email: sales@baiqpharm.com
Country: China
ProdList: 584
Advantage: 58

Shanghai Hanlin biology science and technology co., ltd

Tel: 183-0212-4410 18302124410
Email: Djt18302124410@163.com
Country: China
ProdList: 3000
Advantage: 58

Hubei Co-prosperity Medicine Technonlogy Co., Ltd

Tel: 2383948258 19172820304
Email: 2383948258@qq.com
Country: China
ProdList: 12987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Beijing Stronger Science Co., Ltd.

Tel: 0531-88924771 15614660963
Email: elsa.hang@strongerscience.com
Country: China
ProdList: 10623
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Suzhou Meishi Biotechnology Co., Ltd.

Tel: 1173954148q
Email: meishipharma@126.com
Country: China
ProdList: 20033
Advantage: 58

Shanghai Jianchao Biotechnology Co., LTD

Tel: 15021035486 18081542813
Email: 1804873256@qq.com
Country: China
ProdList: 6684
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Wuxi Renwang Pharmaceutical Co., Ltd

Tel: 17302505019
Email: 1756078593@qq.com
Country: China
ProdList: 132
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Sichuan Boyou Biotechnology Co., Ltd

Tel: 028-65791793 18140026355
Email: 568470422@qq.com
Country: China
ProdList: 9458
Advantage: 58

Shanghai Ken chemical Technology Co.,ltd

Tel: 02152215958
Email: 47697177@qq.com
Country: China
ProdList: 10011
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Changzhou Shili Pharmaceutical Technology Co., Ltd

Tel: 13961229012
Email: shitech@163.com
Country: China
ProdList: 270
Advantage: 58

Hangzhou Milon Pharmatech Co.,Ltd.

Tel: 18083715844
Email: sales@milonpharm.com
Country: China
ProdList: 290
Advantage: 58

Hangzhou Milon Pharmatech Co.,Ltd.

Tel: +8618083715844
Email: sales02@milonpharm.com
Country: China
ProdList: 291
Advantage: 58

HANGZHOU LEAP CHEM CO., LTD.

Tel: +86-571-87711850
Email: market18@leapchem.com
Country: China
ProdList: 43339
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49941
Advantage: 58

Shijiazhuang Simer Technology Co., Ltd.

Tel: --
Fax: --
Email: 542698281@qq.com
Country: CHINA
ProdList: 6695
Advantage: 58

Shanghai Machine Pure Industrial Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6800
Advantage: 58

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: --
Fax: --
Email: sales@rovathin.com
Country: China
ProdList: 4395
Advantage: 58

64874-38-0, 2-AMINO-6-BROMO-1,8-NAPHTHYRIDINERelated Search:

6-Methoxypyrazinamine 6-FLUOROQUINOLIN-2-AMINE 2-Amino-6-Iodobenzothiazole 6-BROMOBENZOXAZOLE ethyl 2-amino-6-chloroisonicotinate 2-amino-6-chloropyridine-4-carboxylic acid 2-Amino-6-chloro-3-pyridinecarboxaldehyde 2-Amino-6-trifluoromethylquinoxaline 2-AMINO-6-BROMOPYRIDO[2,3-D]PYRIMIDIN-4(3H)-ONE 2-Amino-benzothiazole-6-carbonitrile 2-Amino-6-methylpyrazine 2-Amino-5-chloropyridine-3-carboxylic acid ETHYL 2-AMINO-6-CHLOROBENZOATE 2-Amino-6-bromo-pyridine-3-carbaldehyde 6-bromo-3-methoxypyridin-2-amine 2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE 3-Bromo-1,8-naphthyridine 6-BROMO-5,7-DIMETHYL-1,8-NAPHTHYRIDIN-2-AMINE

2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE

6-Bromo-1,8-naphthyridin-2-amine, 2-Amino-6-bromo-1,8-diazanaphthalene

6-BROMO-1,8-NAPHTHYRIDIN-2-AMINE

1,8-Naphthyridin-2-amine, 6-bromo-

64874-38-0

Heterocycle-Pyridine series