1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER

Product Name: 1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
CAS No.: 3697-68-5
Chemical Name: 1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
Synonyms: ethyl 1-(hydroxymethyl)cyclopropane-1-carboxylate;Ethyl 1-(hydroxymethyl);Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate;1,1 Cyclopropane dicarboxylic acid ethyl ester;Ethyl1-(hydroxymethyl)cyclopropanecarboxylate,97%;Ethyl 1-(hydroxyMethyl)cyclopropanecarboxylate, 97%;1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER;Cyclopropanecarboxylic acid, 1-(hydroxyMethyl)-, ethyl ester;1-(hydroxymethyl)-Cyclopropanecarboxylic acid ethyl ester (7CI 8CI 9CI ACI);Cyclopropanecarboxylic acid, 1-(hydroxymethyl)-, ethyl ester (7CI, 8CI, 9CI, ACI)
CBNumber: CB12456914
Molecular Formula: C7H12O3
Formula Weight: 144.17
MOL File: 3697-68-5.mol

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1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Property

Boiling point:: 90-94 °C(Press: 8 Torr)
Density: 1.159±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 15.10±0.10(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C7H12O3/c1-2-10-6(9)7(5-8)3-4-7/h8H,2-5H2,1H3
InChIKey: PAILVKQSHRJIPE-UHFFFAOYSA-N
SMILES: C1(CO)(C(OCC)=O)CC1
CAS DataBase Reference: 3697-68-5

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Safety

HS Code: 2918199890

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: E945755
Product name: Ethyl1-(Hydroxymethyl)cyclopropanecarboxylate
Packaging: 1g
Price: $950
Updated: 2021/12/16

AK Scientific

Product number: 4709AB
Product name: Ethyl1-hydroxymethyl-cyclopropanecarboxylate
Packaging: 1g
Price: $161
Updated: 2021/12/16

Matrix Scientific

Product number: 089541
Product name: Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate
Packaging: 1g
Price: $169
Updated: 2021/12/16

Matrix Scientific

Product number: 089541
Product name: Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate
Packaging: 5g
Price: $507
Updated: 2021/12/16

Matrix Scientific

Product number: 089541
Product name: Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate
Packaging: 25g
Price: $1700
Updated: 2021/12/16

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1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate acts as a ligand for Suzuki coupling reaction.

Synthesis

1559-02-0

3697-68-5

Example 64 Preparation of ethyl 1-(hydroxymethyl)cyclopropanecarboxylate A tetrahydrofuran solution of 1 M tri-tert-butoxy lithium aluminum (70.90 mL, 70.90 mmol) was slowly added dropwise to a stirred solution of diethyl cyclopropane-1,1-dicarboxylate (6 g, 32.20 mmol) in tetrahydrofuran (129 mL). The reaction system was stirred at 23 °C and gradually warmed to 65 °C and maintained at this temperature for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with 10% sodium bisulfate solution (275 mL) and subsequently extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the light yellow oily target product ethyl 1-(hydroxymethyl)cyclopropanecarboxylate (4.60 g, 91% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.16 (q, J = 7 Hz, 2H), 3.62 (s, 2H), 2.60 (br s, 1H), 1.22-1.30 (m, 5H), 0.87 (dd, J = 7, 4 Hz, 2H).

References

[1] Patent: US2012/110702, 2012, A1. Location in patent: Page/Page column 38
[2] Patent: US2013/109566, 2013, A1. Location in patent: Paragraph 0400; 0401
[3] Patent: US2013/288893, 2013, A1. Location in patent: Paragraph 0450-0451
[4] Patent: US2016/60245, 2016, A1. Location in patent: Paragraph 0451; 0452
[5] Patent: US2012/53146, 2012, A1. Location in patent: Paragraph 0170; 0171

1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Suppliers

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View Lastest Price from 1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER 3697-68-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-19

henan kanbei chemical co.,ltd

Product: 1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER 3697-68-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2022-09-26

Career Henan Chemical Co

Product: 1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER 3697-68-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-02

3697-68-5, 1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTERRelated Search:

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1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER

ethyl 1-(hydroxymethyl)cyclopropane-1-carboxylate

Cyclopropanecarboxylic acid, 1-(hydroxyMethyl)-, ethyl ester

Ethyl 1-(hydroxyMethyl)cyclopropanecarboxylate, 97%

Ethyl 1-(hydroxymethyl)

1,1 Cyclopropane dicarboxylic acid ethyl ester

Ethyl1-(hydroxymethyl)cyclopropanecarboxylate,97%

Cyclopropanecarboxylic acid, 1-(hydroxymethyl)-, ethyl ester (7CI, 8CI, 9CI, ACI)

1-(hydroxymethyl)-Cyclopropanecarboxylic acid ethyl ester (7CI 8CI 9CI ACI)

Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate

3697-68-5