Ethyl 4-methyl-5-thiazoleactate

Uses

Product Name: Ethyl 4-methyl-5-thiazoleactate
CAS No.: 20582-55-2
Chemical Name: Ethyl 4-methyl-5-thiazoleactate
Synonyms: ETHYL 4-METHYL-5-THIAZOLEACTATE;Ethyl-4-methyl-5-thiazoly formate;ETHYL 4-METHYL-5-THIAZOLYL FORMATE;Ethyl4-Methylthiazole-5-Carboxylat;Ethyl 4-metylthiazole-5-carboxylate;ETHYL 4-METHYLTHIAZOLE-5-CARBOXYLATE;Ethyl-4-methyl-5-thizaolecarboxylate;ETHYL 4-METHYL-5-THIAZOLECARBOXYLATE;4-methyl-5-(ethoxycarbonyl)-thiazole;5-(Ethoxycarbonyl)-4-methyl-1,3-thiazole
CBNumber: CB7260661
Molecular Formula: C7H9NO2S
Formula Weight: 171.22
MOL File: 20582-55-2.mol

More

Less

Ethyl 4-methyl-5-thiazoleactate Property

Melting point:: 28°C(lit.)
Boiling point:: 233°C(lit.)
Density: 1.198±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to lump
pka: 1.57±0.10(Predicted)
color: White to Almost white
LogP: 1.410 (est)
CAS DataBase Reference: 20582-55-2(CAS DataBase Reference)

More

Less

Safety

HazardClass: IRRITANT
HS Code: 2934208090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: E1182
Product name: Ethyl 4-Methylthiazole-5-carboxylate
Purity: >97.0%(GC)
Packaging: 1g
Price: $67
Updated: 2025/07/31

TCI Chemical

Product number: E1182
Product name: Ethyl 4-Methylthiazole-5-carboxylate
Purity: >97.0%(GC)
Packaging: 5g
Price: $201
Updated: 2025/07/31

TRC

Product number: E937560
Product name: Ethyl4-Methyl-5-thiazoleactate
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 047379
Product name: Ethyl 4-methyl-1,3-thiazole-5-carboxylate
Purity: 95+%
Packaging: 1g
Price: $15
Updated: 2021/12/16

Matrix Scientific

Product number: 047379
Product name: Ethyl 4-methyl-1,3-thiazole-5-carboxylate
Purity: 95+%
Packaging: 5g
Price: $45
Updated: 2021/12/16

More

Less

Ethyl 4-methyl-5-thiazoleactate Chemical Properties,Usage,Production

Uses

Ethyl 4-methylthiazolium-5-carboxylate is a key intermediate in the synthesis of cefditorenpivoxil. Cefditorenpivoxil was developed by Meiji Seika Co., Ltd. of Japan and launched in Japan in 1994 under the trade name Meiact. Cefditorenpivoxil has a broad antibacterial spectrum against both Gram-positive and Gram-negative bacteria.

Chemical Properties

white to light yellow crystal powde

Synthesis

7210-76-6

20582-55-2

General procedure for the synthesis of ethyl 4-methylthiazole-5-carboxylate from ethyl 2-amino-4-methylthiazole-5-carboxylate: compound 3a (4.0 g, 21.5 mmol) was dissolved in 106 mL of 30% hypophosphite (H3PO2) solution. The reaction system was cooled to -5°C, after which sodium nitrite (NaNO2, 3.0 g, 2.0 eq.) was dissolved in 12 mL of water and slowly added dropwise to the reaction solution. After the dropwise addition, the reaction mixture was transferred to 0°C and kept for 1 hour, then stirring was continued for 2 hours at room temperature. Subsequently, pre-cooled sodium hydroxide solution (17 g NaOH dissolved in 200 mL of water) was added slowly dropwise. The reaction mixture was adjusted to neutral with sodium bicarbonate (NaHCO3) solution and then extracted with ether (Et2O, 50 mL x 3). The organic phases were combined and purified by column chromatography (eluent ratio: petroleum ether:ethyl acetate = 50:1, v/v) to give the yellow semi-solid product 3b (2.1 g, 56% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6231 - 6235
[2] Patent: CN101921268, 2016, B. Location in patent: Paragraph 0128; 0131; 0136-0139
[3] Tetrahedron, 2013, vol. 69, # 22, p. 4436 - 4444

Ethyl 4-methyl-5-thiazoleactate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ethyl 4-methyl-5-thiazoleactate Suppliers

Americas 1 China 147 Europe 1 Germany 3 India 22 Japan 2 The Netherlands 1 Ukraine 1 United Kingdom 6 United States 30 Global 214

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.

Tel: 21-54820552 18964669552
Fax: 086-21-64964478
Email: 188738128@qq.com
Country: China
ProdList: 310
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

More

Less

View Lastest Price from Ethyl 4-methyl-5-thiazoleactate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 4-methyl-5-thiazoleactate 20582-55-2
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 1000kg
Release date: 2025-09-09

JINING XINHE CHEMICAL CO., LTD

Product: Ethyl 4-methyl-5-thiazoleactate 20582-55-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10ton
Release date: 2024-07-22

Career Henan Chemical Co

Product: Ethyl 4-methyl-5-thiazoleactate 20582-55-2
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: ask
Release date: 2018-12-20

20582-55-2, Ethyl 4-methyl-5-thiazoleactateRelated Search:

Ethyl formate Bensulfuron methyl 4-Methylthiazole PENICILLIN V Benzocaine 4-Thiazolecarboxylic acid Methylparaben 5-Methylthiazole 2-Methyl-4-isothiazolin-3-one tert-Butyl carbazate METSULFURON METHYL Methyl acrylate N,N,N',N'-Tetramethylethylenediamine Kresoxim-methyl POLY(METHYLSILSESQUIOXANE) N,N-Dimethylacetamide Thiophanate-methyl N-Carbobenzyloxyglycine

ETHYL 4-METHYLTHIAZOLE-5-CARBOXYLATE

ETHYL 4-METHYL-5-THIAZOLEACTATE

ETHYL 4-METHYL-5-THIAZOLYL FORMATE

5-THIAZOLECARBOXYLIC ACID, 4-METHYL-, ETHYL ESTER

Ethyl-4-methyl-5-thizaolecarboxylate

4-Methyl-5-Thiazolecarboxylic Acid Ethyl Ester

ETHYL 4-METHYL-5-THIAZOLECARBOXYLATE

ethyl 4-methyl-1,3-thiazole-5-carboxylate

4-Methyl-thiazole-5-carboxylic acid ethyl ester

Ethyl 4-metylthiazole-5-carboxylate

ethyl 4-methyl-1,3-thiazole-5-carboxylate (en)

5-(Ethoxycarbonyl)-4-methyl-1,3-thiazole

Ethyl4-Methylthiazole-5-Carboxylat

5-Thiazolecarboxylic acid, 4-methyl-, ethyl ester (6CI, 8CI, 9CI, ACI)

4-methyl-5-Thiazolecarboxylic acid ethyl ester (6CI 8CI 9CI ACI)

Ethyl-4-methyl-5-thiazoly formate

4-methyl-5-(ethoxycarbonyl)-thiazole

20582-55-2

20585-55-2

Febuxostat