ChemicalBook > CAS DataBase List > Ethyl 4-methyl-5-thiazoleactate
Ethyl 4-methyl-5-thiazoleactate
Uses- Product Name
- Ethyl 4-methyl-5-thiazoleactate
- CAS No.
- 20582-55-2
- Chemical Name
- Ethyl 4-methyl-5-thiazoleactate
- Synonyms
- ETHYL 4-METHYL-5-THIAZOLEACTATE;Ethyl-4-methyl-5-thiazoly formate;ETHYL 4-METHYL-5-THIAZOLYL FORMATE;Ethyl4-Methylthiazole-5-Carboxylat;Ethyl 4-metylthiazole-5-carboxylate;ETHYL 4-METHYLTHIAZOLE-5-CARBOXYLATE;Ethyl-4-methyl-5-thizaolecarboxylate;ETHYL 4-METHYL-5-THIAZOLECARBOXYLATE;4-methyl-5-(ethoxycarbonyl)-thiazole;5-(Ethoxycarbonyl)-4-methyl-1,3-thiazole
- CBNumber
- CB7260661
- Molecular Formula
- C7H9NO2S
- Formula Weight
- 171.22
- MOL File
- 20582-55-2.mol
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Ethyl 4-methyl-5-thiazoleactate Property
- Melting point:
- 28°C(lit.)
- Boiling point:
- 233°C(lit.)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to lump
- pka
- 1.57±0.10(Predicted)
- color
- White to Almost white
- LogP
- 1.410 (est)
- CAS DataBase Reference
- 20582-55-2(CAS DataBase Reference)
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Safety
- HazardClass
- IRRITANT
- HS Code
- 2934208090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- E1182
- Product name
- Ethyl 4-Methylthiazole-5-carboxylate
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $67
- Updated
- 2025/07/31
TCI Chemical
- Product number
- E1182
- Product name
- Ethyl 4-Methylthiazole-5-carboxylate
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $201
- Updated
- 2025/07/31
TRC
- Product number
- E937560
- Product name
- Ethyl4-Methyl-5-thiazoleactate
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 8H23-1-39
- Product name
- Ethyl 4-methyl-1,3-thiazole-5-carboxylate
- Packaging
- 1g
- Price
- $135
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 047379
- Product name
- Ethyl 4-methyl-1,3-thiazole-5-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
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Ethyl 4-methyl-5-thiazoleactate Chemical Properties,Usage,Production
Uses
Ethyl 4-methylthiazolium-5-carboxylate is a key intermediate in the synthesis of cefditorenpivoxil. Cefditorenpivoxil was developed by Meiji Seika Co., Ltd. of Japan and launched in Japan in 1994 under the trade name Meiact. Cefditorenpivoxil has a broad antibacterial spectrum against both Gram-positive and Gram-negative bacteria.
Chemical Properties
white to light yellow crystal powde
Synthesis
7210-76-6
20582-55-2
General procedure for the synthesis of ethyl 4-methylthiazole-5-carboxylate from ethyl 2-amino-4-methylthiazole-5-carboxylate: compound 3a (4.0 g, 21.5 mmol) was dissolved in 106 mL of 30% hypophosphite (H3PO2) solution. The reaction system was cooled to -5°C, after which sodium nitrite (NaNO2, 3.0 g, 2.0 eq.) was dissolved in 12 mL of water and slowly added dropwise to the reaction solution. After the dropwise addition, the reaction mixture was transferred to 0°C and kept for 1 hour, then stirring was continued for 2 hours at room temperature. Subsequently, pre-cooled sodium hydroxide solution (17 g NaOH dissolved in 200 mL of water) was added slowly dropwise. The reaction mixture was adjusted to neutral with sodium bicarbonate (NaHCO3) solution and then extracted with ether (Et2O, 50 mL x 3). The organic phases were combined and purified by column chromatography (eluent ratio: petroleum ether:ethyl acetate = 50:1, v/v) to give the yellow semi-solid product 3b (2.1 g, 56% yield).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6231 - 6235
[2] Patent: CN101921268, 2016, B. Location in patent: Paragraph 0128; 0131; 0136-0139
[3] Tetrahedron, 2013, vol. 69, # 22, p. 4436 - 4444
Ethyl 4-methyl-5-thiazoleactate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-methyl-5-thiazoleactate manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- Ethyl 4-methyl-5-thiazoleactate 20582-55-2
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2025-09-09
JINING XINHE CHEMICAL CO., LTD
- Product
- Ethyl 4-methyl-5-thiazoleactate 20582-55-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10ton
- Release date
- 2024-07-22
Career Henan Chemical Co
- Product
- Ethyl 4-methyl-5-thiazoleactate 20582-55-2
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- ask
- Release date
- 2018-12-20
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