2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE
- Product Name
- 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE
- CAS No.
- 885618-31-5
- Chemical Name
- 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE
- Synonyms
- 129558;2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE;2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE-5;2-chloro-4-(Morpholin-4-yl)thieno[3,2-d]pyriMidine-6-carbaldehyde;2-chloro-4-(4-morpholinyl)-Thieno[3,2-d]pyrimidine-6-carboxaldehyde;2-Chloro-4-(Morpholin-4-yl)thieno[3,2-d]pyriMidine-6-carboxaldehyde;Thieno[3,2-d]pyriMidine-6-carboxaldehyde, 2-chloro-4-(4-Morpholinyl)-
- CBNumber
- CB12460546
- Molecular Formula
- C11H10ClN3O2S
- Formula Weight
- 283.73
- MOL File
- 885618-31-5.mol
2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE Property
- Density
- 1.522±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.91±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C360490
- Product name
- 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
- Packaging
- 100mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- W9116
- Product name
- 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
- Packaging
- 100mg
- Price
- $217
- Updated
- 2021/12/16
- Product number
- FC154363
- Product name
- 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FC154363
- Product name
- 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC154363
- Product name
- 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE Chemical Properties,Usage,Production
Synthesis
68-12-2
885618-31-5
The general procedure for the synthesis of 2-chloro-4-(4-morpholino)-thieno[3,2-d]pyrimidine-6-carboxaldehyde from N,N-dimethylformamide is as follows: referring to Example 3, a solution of 2-chloro-4-morpholino-4-yl-thieno[3,2-d]pyrimidine (65) (1.75 g, 6.85 mmol) in anhydrous THF (40 mL) was stirred at -78 °C. A hexane solution of 2.5 M n-butyllithium (3.3 mL, 1.2 equiv) was slowly added. The reaction mixture was continued to be stirred at -78 °C for 1 h. Anhydrous N,N-dimethylformamide (796 μL, 1.5 eq.) was added. After keeping the reaction at -78 °C for 1 h, the reaction was slowly warmed up to room temperature. Stirring was continued at room temperature for 2 h. Upon completion of the reaction, the mixture was poured into ice/water and a yellow precipitate precipitated. The precipitate was collected by filtration and air dried to afford the target product 2-chloro-4-(4-morpholino)-thieno[3,2-d]pyrimidine-6-carboxaldehyde (1.50 g, 77% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 3.76 (4H, t, J = 4.9 Hz), 3.95 (4H, t, J = 4.9 Hz), 8.28 (1H, s), 10.20 (1H, s).
References
[1] Patent: WO2006/46031, 2006, A1. Location in patent: Page/Page column 30
[2] Patent: US2008/76768, 2008, A1. Location in patent: Page/Page column 7
[3] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 73
[4] Patent: WO2007/122410, 2007, A1. Location in patent: Page/Page column 63
[5] Patent: WO2007/127183, 2007, A1. Location in patent: Page/Page column 136
2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE manufacturers
- Product
- 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE 885618-31-5
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02