tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

Product Name: tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
CAS No.: 392331-66-7
Chemical Name: tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
Synonyms: 1-Boc-4-(Aminomethyl);1-Boc-4-aMinoMethyl-4-hyd...;4-Aminomethyl-1-Boc-piperidin-4-ol;4-Aminomethyl-1-Boc-4-hydroxypiperidine,97%;4-AMinoMethyl-1-Boc-4-hydroxypiperidine, 97%;tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate;tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 95%;4-Aminomethyl-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(aminomethyl)-4-hydroxy-, 1,1-dimethylethyl ester
CBNumber: CB12470392
Molecular Formula: C11H22N2O3
Formula Weight: 230.3
MOL File: 392331-66-7.mol

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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Property

Boiling point:: 341.0±27.0 °C(Predicted)
Density: 1.124
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 12.48±0.20(Predicted)
form: Solid
color: Off-white
Water Solubility: Slightly soluble in water.
Sensitive: Air Sensitive
InChI: InChI=1S/C11H22N2O3/c1-10(2,3)16-9(14)13-6-4-11(15,8-12)5-7-13/h15H,4-8,12H2,1-3H3
InChIKey: XYWCDAFPRBDRER-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(CN)(O)CC1
CAS DataBase Reference: 392331-66-7

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B809728
Product name: tert-Butyl4-(Aminomethyl)-4-hydroxypiperidine-1-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 047363
Product name: tert-Butyl 4-(aminomethyl)-4-hydroxytetrahydro-1(2H)-pyridinecarboxylate
Purity: >95%
Packaging: 500mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: HTS028901
Product name: tert-butyl4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
Packaging: 20mg
Price: $89
Updated: 2021/12/16

Matrix Scientific

Product number: 047363
Product name: tert-Butyl 4-(aminomethyl)-4-hydroxytetrahydro-1(2H)-pyridinecarboxylate
Purity: >95%
Packaging: 1g
Price: $90
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-NE
Product name: 1-Boc-4-aminomethyl-4-hydroxypiperidine
Packaging: 1g
Price: $98
Updated: 2021/12/16

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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

4-Aminomethyl-1-Boc-4-hydroxypiperidine can be used in agrochemical, pharmaceutical and dyestuff.

Synthesis

147804-30-6

392331-66-7

General procedure for the synthesis of tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate from tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate: In a 100 mL sealed tube, a magnetic stirring bar, tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (300 mg, 1.28 mmol) and 7 M ammonium hydroxide in a methanol solution (20 mL). The reaction mixture was placed in an oil bath at 80°C and stirred for 16 hours. After completion of the reaction, the mixture was cooled to room temperature. The solvent was removed by concentration under reduced pressure to afford the crude product tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate (350 mg, >95% yield), which could be used in the subsequent reaction without further purification.LCMS (ESI) m/z 231 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 24, p. 7458 - 7461
[2] Patent: US2016/185786, 2016, A1. Location in patent: Paragraph 0679
[3] Patent: WO2015/92804, 2015, A1. Location in patent: Page/Page column 21
[4] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 289 - 301
[5] Patent: WO2014/147636, 2014, A1. Location in patent: Page/Page column 35; 36

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Suppliers

China 89 Germany 1 India 4 United Kingdom 2 United States 9 Global 105

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View Lastest Price from tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 392331-66-7
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-27

Career Henan Chemical Co

Product: tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 392331-66-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

392331-66-7, tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylateRelated Search:

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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

1-Boc-4-aMinoMethyl-4-hyd...

tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 95%

4-AMinoMethyl-1-Boc-4-hydroxypiperidine, 97%

4-Aminomethyl-1-Boc-piperidin-4-ol

1-Piperidinecarboxylic acid, 4-(aminomethyl)-4-hydroxy-, 1,1-dimethylethyl ester

1-Boc-4-(Aminomethyl)

4-Aminomethyl-1-Boc-4-hydroxypiperidine,97%

4-Aminomethyl-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

392331-66-7