ChemicalBook > CAS DataBase List > AMG-706

AMG-706

Product Name: AMG-706
CAS No.: 857876-30-3
Chemical Name: AMG-706
Synonyms: CS-459;AMG-706;Unii-T6Q3060U91;Diphosphate salt;AMG-706 USP/EP/BP;Motesanib(AMG-706);Motesanib phosphate;Motesanib diphosphate;AMG706; AMG 706; AMG-706;Motesanib, Diphosphate Salt
CBNumber: CB12473858
Molecular Formula: C22H29N5O9P2
Formula Weight: 569.441282
MOL File: 857876-30-3.mol

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AMG-706 Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: ≥28.45 mg/mL in DMSO; insoluble in H2O; ≥3.47 mg/mL in EtOH with ultrasonic
form: Powder
color: White to off-white
InChIKey: ONDPWWDPQDCQNJ-UHFFFAOYSA-N
SMILES: CC1(C2C=CC(=CC=2NC1)NC(=O)C1C=CC=NC=1NCC1C=CN=CC=1)C.OP(=O)(O)O.OP(=O)(O)O

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.38169
Product name: Motesanib, Diphosphate
Packaging: 10 mg
Price: $111
Updated: 2025/07/31

Cayman Chemical

Product number: 17671
Product name: AMG 706
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17671
Product name: AMG 706
Purity: ≥98%
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 17671
Product name: AMG 706
Purity: ≥98%
Packaging: 10mg
Price: $211
Updated: 2024/03/01

Cayman Chemical

Product number: 17671
Product name: AMG 706
Purity: ≥98%
Packaging: 50mg
Price: $660
Updated: 2024/03/01

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AMG-706 Chemical Properties,Usage,Production

Uses

An oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.

Uses

Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.

Biological Activity

motesanib diphosphate is a diphosphate form of motesanib. it is a potent atp-competitive inhibitor of vegfr1/2/3 with ic50 of 2 nm/3 nm/6 nm, respectively [1].vascular endothelial growth factor (vegf) is an important signaling protein involved in both vasculogenesis (the formation of the circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). motesanib (amg 706) is an orally administered small molecule belonging to angiokinase inhibitor class which acts as an antagonist of vegf receptors, platelet-derived growth factor receptors, and stem cell factor receptors.

in vitro

motesanib diphosphate has broad activity against the human vegfr family, and displays >1000 selectivity against egfr, src, and p38 kinase. motesanib diphosphate significantly inhibits vegf-induced cellular proliferation of huvecs with an ic50 of 10 nm, while displaying little effect at bfgf-induced proliferation with an ic50 of >3,000 nm. motesanib diphosphate also potently inhibits pdgf-induced proliferation and scf-induced c-kit phosphorylation with ic50 of 207 nm and 37 nm, respectively, but not effective against the egf-induced egfr phosphorylation and cell viability of a431 cells [1]. althouth displaying little antiproliferative activity on cell growth of huvecs alone, motesanib diphosphate treatment significantly sensitizes the cells to fractionated radiation [2].

in vivo

oral administration of amg 706 potently inhibited vegf-induced angiogenesis in the rat corneal model and induced regression of established a431 xenografts. amg 706 was well tolerated and had no significant effects o amg 706n body weight or on the general health of the animals. histologic analysis of tumor xenografts from amg 706–treated animals revealed an increase in endothelial apoptosis and a reduction in blood vessel area that preceded an increase in tumor cell apoptosis. in summary, amg 706 is an orally bioavailable, well-tolerated multikinase inhibitor that is presently under clinical investigation for the treatment of human malignancies [1].

target

VEGFR

IC 50

VEGFR1: 2 nM (IC₅₀); VEGFR2: 3 nM (IC₅₀); VEGFR3: 6 nM (IC₅₀)

AMG-706 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMG-706 Suppliers

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View Lastest Price from AMG-706 manufacturers

Career Henan Chemical Co

Product: AMG-706 857876-30-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

857876-30-3, AMG-706Related Search:

Motesanib Axitinib Linifanib (ABT-869) Tozasertib PD 0325901 DAPT PD184352 (CI-1040)

Motesanib, Diphosphate Salt

AMG-706

Motesanib(AMG-706)

Motesanib diphosphate

Motesanib diphosphate [usan]

Unii-T6Q3060U91

N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide diphosphate

AMG706; AMG 706; AMG-706

CS-459

N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide,phosphoric acid

N-(2,3-Dihydro-3,3-diMethyl-1H-indol-6-yl)-2-[(4-pyridinylMethyl)aMino]-3-pyridinecarboxaMide Phosphate

Motesanib Diphosphate (AMG-706)

3-Pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-, phosphate (1:2)

Diphosphate salt

AMG706 (Motesanib Diphosphate)

Motesanib Diphosphate (AMG-706) VM-2005

Motesanib phosphate

AMG706;AMG 706;AMG-706;MOTESANIB

AMG-706 USP/EP/BP

N-(3,3-Dimethylindolin-6-yl)-2-((pyridin-4-ylmethyl)amino)nicotinamide diphosphate

Motesanib Diphosphate AMG706 AMG-706

N-(3,3-dimethylindolin-6-yl)-2-((pyridin-4-ylmethyl)amino)nicotinamide phosphate

Motesanib Diphosphate (AM -706) VM-2005

Motesanib Diphosphate, 10 mM in DMSO

857876-30-3

57876-30-3

C22H26N5O5P

C22H23N5O2H3PO4

C22H29N5O9P2

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