ChemicalBook > CAS DataBase List > (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

Product Name
(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
CAS No.
147489-06-3
Chemical Name
(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Synonyms
T-Butyl (3R;t-Butyl (3R,5S);tert-butyl 2-((4R,6S);Pitavastatin Calcium Impurity F;Pivastatin calcium intermediate;5-isopropylidenedioxy-6-heptenoate;-7-[2-cyclopropyl-4-(4-fluorophenyl);pitavastatin intermediate 3R5S isomer;Pirvastatin isopropyl tert butyl ester;3-dioxane-6-heptene?acid?tert-butyl?ester
CBNumber
CB12485022
Molecular Formula
C32H36FNO4
Formula Weight
517.63
MOL File
147489-06-3.mol
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(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Property

Melting point:
105-116 °C(Solv: hexane (110-54-3))
Boiling point:
604.6±55.0 °C(Predicted)
Density 
1.184±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.61±0.50(Predicted)
color 
White to Off-White
InChIKey
GTJPCLUSFUIHTP-KAAYJFPCSA-N
SMILES
O1[C@H](/C=C/C2=C(C3=CC=C(F)C=C3)C3C(N=C2C2CC2)=CC=CC=3)C[C@H](CC(OC(C)(C)C)=O)OC1(C)C
CAS DataBase Reference
147489-06-3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B689830
Product name
t-Butyl(3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
Packaging
500mg
Price
$195
Updated
2021/12/16
Matrix Scientific
Product number
092059
Product name
t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
Purity
95+%
Packaging
1g
Price
$99
Updated
2021/12/16
Matrix Scientific
Product number
092059
Product name
t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
Purity
95+%
Packaging
5g
Price
$267
Updated
2021/12/16
Matrix Scientific
Product number
092059
Product name
t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
Purity
95+%
Packaging
10g
Price
$475
Updated
2021/12/16
AK Scientific
Product number
X6293
Product name
(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-2,2-Dimethyl-1,3-dioxane-6-heptenoicacid1,1-dimethylethylester
Packaging
10g
Price
$609
Updated
2021/12/16
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(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Chemical Properties,Usage,Production

Uses

t-Butyl (3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate is an impurity from the synthesis of HMG-CoA reductase inhibitor Pitavastatin [P531040, (Z)-Pitavastatin Calcium Salt].

(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Suppliers

China 159 India 4 United States 9 Global 172
Shandong Kongfu Pharmaceutical Co
Tel
0537-4442222 18854777456
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871825068@qq.com
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China
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JIANGXI AIFEIMU TECHNOLOGY CO.,LTD
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793-33899567 13735087952
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+86-570-6259526
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sales@afmpharm.com
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China
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Hubei Hicks Biochemical Co., Ltd
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17362916295; 17362916295
Email
w17362916295@163.com
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China
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3992
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Shandong Meiao Huawei Technology Co., LTD
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0531-88682301 18595278766
Email
yuhongmeng@mayowell.com
Country
China
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Yulin Runtianchang Chemical Co., Ltd
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15890142075
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3555133855@qq.com
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China
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9850
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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14101
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
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64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
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64
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
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7811
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57
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
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View Lastest Price from (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester 147489-06-3
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
WUHAN FORTUNA CHEMICAL CO., LTD
Product
(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester 147489-06-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10kg/month
Release date
2022-12-28
Nanjing Fred Technology Co., Ltd
Product
(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester 147489-06-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-03

147489-06-3, (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl esterRelated Search:

Pitavastatin Impurity 2 Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Pitavastatin Methyl Ester PITAVASTATIN LACTONE 2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde 2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol [2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido Tert-buthyl Pitavastatin tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal (3S,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid CalciuM Salt (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid CalciuM Salt 3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Rosuvastatin calcium Pitavastatin calcium

  • (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
  • tert-Butyl(3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
  • (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluoro?phenyl)3-quinoline-base]-2,2-dimethyl-1,3-dioxane-6-heptene?acid?tert-butyl?ester
  • tert-butyl 2-((4R,6S)
  • pitavastatin intermediate 3R5S isomer
  • 2-[6-[2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert-butyl ester
  • 3-dioxane-6-heptene?acid?tert-butyl?ester
  • 6E)-7-[2-cyclopropyl-4-(4-fluoro?phenyl)3-quinoline-base]-2
  • (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-2,2-Dimethyl-1,3-dioxane-6- heptenoic acid,1,1-dimethylethyl ester
  • t-Butyl-(3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
  • t-Bytyl(3R,5S)-7-[2-cyclopropyl-4-(4-fluoropenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
  • (3R,5S,E)-tert-butyl7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate
  • t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-hepte
  • 1,3-Dioxane-4-acetic acid,6-[(1E)-2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-,1,1-dimethylethyl ester,(4R,6S)-
  • -7-[2-cyclopropyl-4-(4-fluorophenyl)
  • quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
  • t-Butyl (3R,5S)
  • t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-he
  • (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4
  • 5-isopropylidenedioxy-6-heptenoate
  • 5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3
  • Pitavastatin Calcium Impurity F
  • T-Butyl (3R
  • (4R,6S)-6-[[(1E)-2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl]-2,2-dimethyl-1, 3-Dioxane-4-acetic acid tert-butyl ester
  • tert-butyl 2-((4R,6S)-6-((E)-2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
  • t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-...
  • tert-butyl 2-((4R,6S)-6-((E)-2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)vinyl)-2,2-dimethyl-1,
  • -Butyl(3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
  • 1,3-Dioxane-4-acetic acid, 6-[(1E)-2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6S)- (9CI, ACI)
  • 6-[(1E)-2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester (4R,6S)- (9CI ACI)
  • Pivastatin calcium intermediate
  • (4R, 6S) -6- [[(1E) -2-cyclopropyl-4- (4-fluorophenyl) -3-quinolinyl] ethenyl] -2,2-dimethyl-1,3-dioxolane-4-acetic acid tert butyl ester
  • (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl]-2,2-dimethyl-1,3-dioxane-4-acetatetert-butylester
  • Pirvastatin isopropyl tert butyl ester
  • (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2,2-dimethyl-1,3-dioxane-6-heptenoic acid tert-butyl ester
  • 147489-06-3