2-bromo-4-mehtoxyl-5-hydroxybenzoic acid

Product Name: 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid
CAS No.: 121936-68-3
Chemical Name: 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid
Synonyms: 6-Bromoisovanillic acid;2-bromo-4-methoxy-5-hydroxybenzoic acid;2-bromo-4-mehtoxyl-5-hydroxybenzoic acid,;2-AMino-5-broMo-3-difluoroMethoxypyridine;Benzoic acid, 2-bromo-5-hydroxy-4-methoxy-;2-Amino-3-Difluoromethoxy-5-Bromopyridine ;2.5.4-2 Bromo 4 methoxy 5 hydroxybenzoic acid;2-bromo-4-mehtoxyl-5-hydroxybenzoic acid ISO 9001：2015 REACH
CBNumber: CB12489611
Molecular Formula: C8H7BrO4
Formula Weight: 247.04
MOL File: 121936-68-3.mol

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2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Property

Boiling point:: 367℃
Density: 1.757
Flash point:: 176℃
storage temp.: RT, stored under nitrogen
pka: 3.00±0.10(Predicted)
Appearance: Off-white to gray Solid
InChI: InChI=1S/C8H7BrO4/c1-13-7-3-5(9)4(8(11)12)2-6(7)10/h2-3,10H,1H3,(H,11,12)
InChIKey: QOHWIPQTBHQOQW-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(O)=C(OC)C=C1Br

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Safety

HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: X9509
Product name: 2-Amino-5-bromo-3-difluoromethoxypyridine
Packaging: 5g
Price: $172
Updated: 2021/12/16

Matrix Scientific

Product number: 090277
Product name: 2-Amino-5-bromo-3-difluoromethoxypyridine
Purity: 95+%
Packaging: 250mg
Price: $198
Updated: 2021/12/16

AK Scientific

Product number: X9509
Product name: 2-Amino-5-bromo-3-difluoromethoxypyridine
Packaging: 10g
Price: $266
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2629-9-37
Product name: 2-Bromo-5-hydroxy-4-methoxybenzoic acid
Packaging: 1g
Price: $437
Updated: 2021/12/16

Matrix Scientific

Product number: 090277
Product name: 2-Amino-5-bromo-3-difluoromethoxypyridine
Purity: 95+%
Packaging: 1g
Price: $437
Updated: 2021/12/16

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2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Chemical Properties,Usage,Production

Synthesis

2973-59-3

121936-68-3

The general procedure for the synthesis of 2-bromo-5-hydroxy-4-methoxybenzoic acid (B13) from 2-bromo-5-hydroxy-4-methoxybenzaldehyde (B2) is as follows: 1. 1 kg of 2-bromo-5-hydroxy-4-methoxybenzaldehyde (B2) and 1.255 kg of sulfamic acid were added to a solvent mixture containing 4.473 kg of EtOAc and 8 L of water under stirring conditions. Stirring was continued until all solids were completely dissolved. 2. Cool the reaction mixture to -10 to 0 °C. 3. In a separate vessel, an aqueous sodium chlorite solution was prepared by dissolving 505 g of sodium chlorite in 3 L of water. 4. Slowly add the sodium chlorite solution dropwise to the pre-cooled B2 solution while keeping the reaction temperature below 5 °C. 5. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0 °C for 1 hour, followed by natural warming to room temperature. 6. The reaction was monitored by thin layer chromatography (TLC). 7. After completion of the reaction, the aqueous layer was separated. The aqueous layer was extracted with 1.789 kg EtOAc, the organic phases were combined and transferred to another flask. 8. EtOAc was removed by vacuum distillation at 40 °C. 9. 9. 6.92 kg of toluene was added at 30 to 40 °C, the slurry was cooled to -10 to 0 °C, and the precipitate was collected by filtration to give about 950 g (89% yield) of 2-bromo-5-hydroxy-4-methoxybenzoic acid (B13). Product characterization: 1H NMR (CDCl3) δ 3.95 (3H, s, OCH3), 7.22 (1H, s, Ar-H), 7.46 (1H, s, Ar-H).

References

[1] Patent: US2008/255347, 2008, A1. Location in patent: Page/Page column 5

2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Suppliers

China 99 India 2 Switzerland 1 United Kingdom 1 United States 6 Global 109

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

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View Lastest Price from 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid manufacturers

Qiuxian Baitai New Material Co., LTD

Product: 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid 121936-68-3
Price: US $25.00/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-12-07

Dideu Industries Group Limited

Product: 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid 121936-68-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-23

Shijiazhuang tongyang Import and Export Co., LTD

Product: 2-Amino-3-Difluoromethoxy-5-Bromopyridine 121936-68-3
Price: US $10.00/KG
Min. Order: 1g
Purity: 99
Supply Ability: 52ton
Release date: 2021-08-12

121936-68-3, 2-bromo-4-mehtoxyl-5-hydroxybenzoic acidRelated Search:

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121936-68-3

Heterocycle-Pyridine series