1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid

Product Name: 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid
CAS No.: 862574-88-7
Chemical Name: 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid
Synonyms: 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxylic acid;EOS-61000;1-(2,2-DifL;uorobenzo[1,3]dioxoL;Lumacator intermediate;Tezacaftor intermediate 03;1-(2,2-Difluorobenzo[1,3]dioxol-5-yl);1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropan;1-(2,2-Difluorobenzodioxol-5-yl)cyclopropanecarboxylic acid;1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxyl
CBNumber: CB12489626
Molecular Formula: C11H8F2O4
Formula Weight: 242.18
MOL File: 862574-88-7.mol

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1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid Property

Boiling point:: 331.1±42.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform; Dichloromethane; Methanol
pka: 4.03±0.20(Predicted)
form: Solid
color: White
InChI: InChI=1S/C11H8F2O4/c12-11(13)16-7-2-1-6(5-8(7)17-11)10(3-4-10)9(14)15/h1-2,5H,3-4H2,(H,14,15)
InChIKey: IELWGOUPQRHXLS-UHFFFAOYSA-N
SMILES: C1(C2=CC=C3OC(F)(F)OC3=C2)(C(O)=O)CC1

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Safety

HS Code: 2932990025
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D445673
Product name: 1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarboxylicAcid
Packaging: 5g
Price: $60
Updated: 2021/12/16

TRC

Product number: D445673
Product name: 1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarboxylicAcid
Packaging: 1g
Price: $40
Updated: 2021/12/16

ChemScene

Product number: CS-M2012
Product name: Cyclopropanecarboxylicacid,1-(2,2-difluoro-1,3-benzodioxol-5-yl)-
Purity: 99.92%
Packaging: 10g
Price: $58
Updated: 2021/12/16

ChemScene

Product number: CS-M2012
Product name: Cyclopropanecarboxylicacid,1-(2,2-difluoro-1,3-benzodioxol-5-yl)-
Purity: 99.92%
Packaging: 25g
Price: $121
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD105869
Product name: 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxyl
Packaging: 2g
Price: $130
Updated: 2021/12/16

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1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid Chemical Properties,Usage,Production

Uses

1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarboxylic Acid is used in processes for preparation of Tezacaftor and intermediates thereof.

Synthesis

Compound 21 was hydrolyzed with 6 M NaOH (8 eq.) in ethanol (5 v/v) at 80C. The mixture was cooled to room temperature during the night and the ethanol was evaporated under vacuum. The residue was put into water, MTBE, 1 M HCl was added and the layers were separated. The MTBE layer was then treated with dicyclohexylamine (0.97 eq.). The slurry was cooled to 0C., filtered and washed with heptane to obtain the corresponding DCHA salt. The salts were placed in MTBE and 10% citric acid and stirred until all solids were dissolved. The layers were separated and the MTBE layer was washed with water and brine. After drying in a vacuum oven at 50C, the solvent was exchanged to heptane and then filtered to give compound 1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)cyclopropanecarboxylic acid. Yield 69%.

1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid Suppliers

China 199 India 5 United Kingdom 1 United States 9 Global 214

Fuxin Custchem Fine Chemical Co., Ltd.

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China Shenyang Tyschem CO. ,LTD

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View Lastest Price from 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid 862574-88-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-06

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid 862574-88-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-27

Zhengzhou Anbu Chem Co.,Ltd

Product: 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid 862574-88-7
Price: US $0.00/KG
Min. Order: 0.1KG
Purity: 98%
Supply Ability: 1000KGS
Release date: 2023-07-14

862574-88-7, 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacidRelated Search:

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862574-88-7

862547-88-7