3-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Product Name
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
- CAS No.
- 1111638-10-8
- Chemical Name
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Synonyms
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine;5H-Pyrrolo[2,3-b]pyrazine, 3-chloro-
- CBNumber
- CB12489969
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 1111638-10-8.mol
3-Chloro-5H-pyrrolo[2,3-b]pyrazine Property
- Density
- 1.531
- storage temp.
- 2-8°C
- pka
- 10?+-.0.50(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C6H4ClN3/c7-5-3-9-4-1-2-8-6(4)10-5/h1-3H,(H,8,10)
- InChIKey
- QWTQGZAUKADLTO-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=NC=C(Cl)N=2
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C380400
- Product name
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Packaging
- 500mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 006694
- Product name
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Packaging
- 100mg
- Price
- $475
- Updated
- 2021/12/16
- Product number
- OR932970
- Product name
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $261
- Updated
- 2021/12/16
- Product number
- 2047AA
- Product name
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Packaging
- 250mg
- Price
- $181
- Updated
- 2021/12/16
- Product number
- OR932970
- Product name
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Purity
- 98%
- Packaging
- 1g
- Price
- $595
- Updated
- 2021/12/16
3-Chloro-5H-pyrrolo[2,3-b]pyrazine Chemical Properties,Usage,Production
Uses
3-Chloro-5H-pyrrolo[2,3-b]pyrazine is used in the preparation of pyrazole compounds as Raf inhibitors.
Synthesis
1111638-09-5
1111638-10-8
Step 3: A solution of 6-chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine (6.0 g, 26.57 mmol) in anhydrous THF (130 mL) was cooled to 0°C. In another vessel, potassium tert-butanolate (tBuOK, 5.96 g, 53.15 mmol) was suspended in THF (30 mL). This suspension was slowly added to the previously cooled solution. The reaction mixture was stirred at 0 °C for 30 min and then warmed up to reflux state for 2.5 h of reaction. The progress of the reaction was monitored by thin layer chromatography (TLC, 30% ethyl acetate/hexane) to confirm complete consumption of the feedstock. Upon completion of the reaction, the mixture was cooled to 25 °C and filtered through a bed of diatomaceous earth to remove insoluble impurities. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was further purified by column chromatography on silica gel (100-200 mesh) using ethyl acetate/hexane (25:60) as eluent to afford the final brown solid product 3-chloro-5H-pyrrolo[2,3-b]pyrazine (2.51 g, 61% yield). Mass spectrometry (MS) analysis showed m/z(ES): 154(M+H)+.
References
[1] Patent: US2011/59118, 2011, A1. Location in patent: Page/Page column 88-89
[2] Patent: WO2016/203404, 2016, A1. Location in patent: Paragraph 00336
3-Chloro-5H-pyrrolo[2,3-b]pyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-5H-pyrrolo[2,3-b]pyrazine Suppliers
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View Lastest Price from 3-Chloro-5H-pyrrolo[2,3-b]pyrazine manufacturers
- Product
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine 1111638-10-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine 1111638-10-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31