ChemicalBook > CAS DataBase List > XRP44X

XRP44X

Product Name: XRP44X
CAS No.: 729605-21-4
Chemical Name: XRP44X
Synonyms: XRP44X;XRP44X, 10 mM in DMSO;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem;[4-(3-chlorophenyl)piperazin-1-yl]-(5-methyl-2-phenylpyrazol-3-yl)methanone;1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine;Piperazine,1-(3-chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]-;(4-(3-Chlorophenyl)piperazin-1-yl)(3-methyl-1-phenyl-1H-pyrazol-5-yl)methanone;[4-(3-Chlorophenyl)piperazin-1-yl](5-methyl-2-phenyl-2H-pyrazol-3-yl)methanone;[4-(3-Chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-methanone
CBNumber: CB12502879
Molecular Formula: C21H21ClN4O
Formula Weight: 380.87
MOL File: 729605-21-4.mol

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XRP44X Property

Melting point:: 136-140 0C
Boiling point:: 591.1±50.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥20mg/mL
pka: 1.79±0.20(Predicted)
form: White solid
color: white to off-white

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: 257135
Product name: XRP44X
Packaging: 10mg
Price: $466
Updated: 2021/12/16

TRC

Product number: X750960
Product name: XRP44X
Packaging: 100mg
Price: $1200
Updated: 2021/12/16

ApexBio Technology

Product number: B7276
Product name: XRP44X
Packaging: 10mg
Price: $322
Updated: 2021/12/16

Matrix Scientific

Product number: 132740
Product name: (4-(3-Chlorophenyl)piperazin-1-yl)(3-methyl-1-phenyl-1H-pyrazol-5-yl)methanone
Purity: 97%
Packaging: 10mg
Price: $702
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001258
Product name: XRP44X
Purity: 95.00%
Packaging: 10MG
Price: $709.46
Updated: 2021/12/16

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XRP44X Chemical Properties,Usage,Production

Uses

XRP44X, is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.XRP44X is used as an anti-cancer drug targeting epidermal growth factor receptor.

Definition

ChEBI: [4-(3-chlorophenyl)-1-piperazinyl]-(5-methyl-2-phenyl-3-pyrazolyl)methanone is a member of piperazines.

General Description

A cell-permeable pyrazole compound that is shown to prevent in vitro tubulin polymerization (IC₅₀ = 0.2 μM) by targeting Colchicine (Cat. No. 234115) binding site (Kd = 0.3 μM) in cell-free assays and induce blebs formation in HUVEC cultures by perturbing both tubulin microtubles and actin cytoskeleton structures. Unrelated to its effects on actin and tubulin filaments, XRP44X is also reported to block the activations of Ras and its downstream effector molecules, such as Raf, MEK, Erk, Rsk, and Net (Elk-3/SAP-2/Erp), upon FGF-2 (Cat. No. 341595) stimulation. Potently inhibits the growth of HUVEC, NIH3T3, as well as 9 other cancer cell lines in antiproliferation assays (IC₅₀ ≤11.3 nM).

Biochem/physiol Actions

XRP44X is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.

in vivo

XRP44X may have therapeutic potential for refractory asthma^[1].
XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, inhibits tumor growth and metastasis in mice. XRP44X inhibits tumor growth and metastasis in nude mice. XRP44X decreases the growth of tumours and the formation of metastases in nude mice^[2].

Animal Model:	Male nude mice (BALB/c nu/nu)^[2]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; treated daily for 6 days
Result:	Inhibited cell tumor formation by xenografts in nude mice.

IC 50

Ras: 10 nM (IC₅₀)

XRP44X Preparation Products And Raw materials

Raw materials

Preparation Products

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XRP44X Suppliers

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729605-21-4, XRP44XRelated Search:

Piperazine

XRP44X

1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine

[4-(3-Chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-methanone

[4-(3-Chlorophenyl)piperazin-1-yl](5-methyl-2-phenyl-2H-pyrazol-3-yl)methanone

(4-(3-Chlorophenyl)piperazin-1-yl)(3-methyl-1-phenyl-1H-pyrazol-5-yl)methanone

Ras-Net (Elk-3) Pathway Inhibitor, XRP44X

Piperazine,1-(3-chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]-

[4-(3-chlorophenyl)piperazin-1-yl]-(5-methyl-2-phenylpyrazol-3-yl)methanone

Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem

Methanone, [4-(3-chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-

Ras/Erk activation,inhibit,Ras-induced transcription,Ras,refractory asthma,microtubules,XRP44X,Inhibitor

XRP44X, 10 mM in DMSO

729605-21-4