ChemicalBook > CAS DataBase List > XRP44X

XRP44X

Product Name
XRP44X
CAS No.
729605-21-4
Chemical Name
XRP44X
Synonyms
XRP44X;XRP44X, 10 mM in DMSO;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem;[4-(3-chlorophenyl)piperazin-1-yl]-(5-methyl-2-phenylpyrazol-3-yl)methanone;1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine;Piperazine,1-(3-chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]-;(4-(3-Chlorophenyl)piperazin-1-yl)(3-methyl-1-phenyl-1H-pyrazol-5-yl)methanone;[4-(3-Chlorophenyl)piperazin-1-yl](5-methyl-2-phenyl-2H-pyrazol-3-yl)methanone;[4-(3-Chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-methanone
CBNumber
CB12502879
Molecular Formula
C21H21ClN4O
Formula Weight
380.87
MOL File
729605-21-4.mol
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XRP44X Property

Melting point:
136-140 0C
Boiling point:
591.1±50.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
pka
1.79±0.20(Predicted)
form 
White solid
color 
white to off-white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological
Product number
257135
Product name
XRP44X
Packaging
10mg
Price
$466
Updated
2021/12/16
TRC
Product number
X750960
Product name
XRP44X
Packaging
100mg
Price
$1200
Updated
2021/12/16
ApexBio Technology
Product number
B7276
Product name
XRP44X
Packaging
50mg
Price
$1308
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001258
Product name
XRP44X
Purity
95.00%
Packaging
0.05G
Price
$1340
Updated
2021/12/16
AK Scientific
Product number
9763AF
Product name
XRP44X
Packaging
10mg
Price
$997
Updated
2021/12/16
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XRP44X Chemical Properties,Usage,Production

Uses

XRP44X, is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.XRP44X is used as an anti-cancer drug targeting epidermal growth factor receptor.

Definition

ChEBI: [4-(3-chlorophenyl)-1-piperazinyl]-(5-methyl-2-phenyl-3-pyrazolyl)methanone is a member of piperazines.

General Description

A cell-permeable pyrazole compound that is shown to prevent in vitro tubulin polymerization (IC50 = 0.2 μM) by targeting Colchicine (Cat. No. 234115) binding site (Kd = 0.3 μM) in cell-free assays and induce blebs formation in HUVEC cultures by perturbing both tubulin microtubles and actin cytoskeleton structures. Unrelated to its effects on actin and tubulin filaments, XRP44X is also reported to block the activations of Ras and its downstream effector molecules, such as Raf, MEK, Erk, Rsk, and Net (Elk-3/SAP-2/Erp), upon FGF-2 (Cat. No. 341595) stimulation. Potently inhibits the growth of HUVEC, NIH3T3, as well as 9 other cancer cell lines in antiproliferation assays (IC50 ≤11.3 nM).

Biochem/physiol Actions

XRP44X is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.

XRP44X Preparation Products And Raw materials

Raw materials

Preparation Products

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XRP44X Suppliers

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729605-21-4, XRP44XRelated Search:

Piperazine

  • XRP44X
  • 1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine
  • [4-(3-Chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-methanone
  • [4-(3-Chlorophenyl)piperazin-1-yl](5-methyl-2-phenyl-2H-pyrazol-3-yl)methanone
  • (4-(3-Chlorophenyl)piperazin-1-yl)(3-methyl-1-phenyl-1H-pyrazol-5-yl)methanone
  • Ras-Net (Elk-3) Pathway Inhibitor, XRP44X
  • Piperazine,1-(3-chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]-
  • [4-(3-chlorophenyl)piperazin-1-yl]-(5-methyl-2-phenylpyrazol-3-yl)methanone
  • Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem
  • Methanone, [4-(3-chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-
  • Ras/Erk activation,inhibit,Ras-induced transcription,Ras,refractory asthma,microtubules,XRP44X,Inhibitor
  • XRP44X, 10 mM in DMSO
  • 729605-21-4