XRP44X

Product Name: XRP44X
CAS No.: 729605-21-4
Chemical Name: XRP44X
Synonyms: XRP44X;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem;[4-(3-chlorophenyl)piperazin-1-yl]-(5-methyl-2-phenylpyrazol-3-yl)methanone;1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine;Piperazine,1-(3-chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]-;(4-(3-Chlorophenyl)piperazin-1-yl)(3-methyl-1-phenyl-1H-pyrazol-5-yl)methanone;[4-(3-Chlorophenyl)piperazin-1-yl](5-methyl-2-phenyl-2H-pyrazol-3-yl)methanone;[4-(3-Chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-methanone;Methanone, [4-(3-chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-
CBNumber: CB12502879
Molecular Formula: C21H21ClN4O
Formula Weight: 380.87
MOL File: 729605-21-4.mol

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XRP44X Property

Melting point:: 136-140 0C
Boiling point:: 591.1±50.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥20mg/mL
pka: 1.79±0.20(Predicted)
form: White solid
color: white to off-white

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: 257135
Product name: XRP44X
Packaging: 10mg
Price: $466
Updated: 2021/12/16

TRC

Product number: X750960
Product name: XRP44X
Packaging: 100mg
Price: $1200
Updated: 2021/12/16

ApexBio Technology

Product number: B7276
Product name: XRP44X
Packaging: 50mg
Price: $1308
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001258
Product name: XRP44X
Purity: 95.00%
Packaging: 0.05G
Price: $1340
Updated: 2021/12/16

AK Scientific

Product number: 9763AF
Product name: XRP44X
Packaging: 10mg
Price: $997
Updated: 2021/12/16

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XRP44X Chemical Properties,Usage,Production

Uses

XRP44X, is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.XRP44X is used as an anti-cancer drug targeting epidermal growth factor receptor.

Definition

ChEBI: [4-(3-chlorophenyl)-1-piperazinyl]-(5-methyl-2-phenyl-3-pyrazolyl)methanone is a member of piperazines.

General Description

A cell-permeable pyrazole compound that is shown to prevent in vitro tubulin polymerization (IC₅₀ = 0.2 μM) by targeting Colchicine (Cat. No. 234115) binding site (Kd = 0.3 μM) in cell-free assays and induce blebs formation in HUVEC cultures by perturbing both tubulin microtubles and actin cytoskeleton structures. Unrelated to its effects on actin and tubulin filaments, XRP44X is also reported to block the activations of Ras and its downstream effector molecules, such as Raf, MEK, Erk, Rsk, and Net (Elk-3/SAP-2/Erp), upon FGF-2 (Cat. No. 341595) stimulation. Potently inhibits the growth of HUVEC, NIH3T3, as well as 9 other cancer cell lines in antiproliferation assays (IC₅₀ ≤11.3 nM).

Biochem/physiol Actions

XRP44X is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.

XRP44X Preparation Products And Raw materials

Raw materials

Preparation Products

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XRP44X Suppliers

China 37 India 1 United Kingdom 1 United States 10 Global 49

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Shanghai Raise Chemical Technology Co.,Ltd

Tel: 15026594951
Fax: 0556-5030632
Email: rs@raise-chem.com
Country: China
ProdList: 3576
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai Yunpun industrial Co.,Ltd

Tel: 21-61726900 15202122459
Fax: +86-21-60277507
Email: sales@yunpun.com
Country: China
ProdList: 499
Advantage: 58

Shanghai Pingguo Pharmaceutical Co., Ltd.

Tel: 021-20432229
Fax: QQ2412110556
Email: 2412110556@qq.com
Country: China
ProdList: 6017
Advantage: 55

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: 1014988033@qq.com
Country: China
ProdList: 4983
Advantage: 55

Wuhan HongxinKang Fine Chemical Co., Ltd.

Tel: 027-59362599 18674037007
Fax: 027-84802889
Email: zhuoxingwc@163.com
Country: China
ProdList: 949
Advantage: 58

Shanghai Benso Pharmaceutical Technology Co., Ltd.

Tel: 15088289376
Email: 248775804@qq.com
Country: China
ProdList: 4983
Advantage: 58

729605-21-4, XRP44XRelated Search:

Piperazine

XRP44X

1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine

[4-(3-Chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-methanone

[4-(3-Chlorophenyl)piperazin-1-yl](5-methyl-2-phenyl-2H-pyrazol-3-yl)methanone

(4-(3-Chlorophenyl)piperazin-1-yl)(3-methyl-1-phenyl-1H-pyrazol-5-yl)methanone

Ras-Net (Elk-3) Pathway Inhibitor, XRP44X

Piperazine,1-(3-chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]-

[4-(3-chlorophenyl)piperazin-1-yl]-(5-methyl-2-phenylpyrazol-3-yl)methanone

Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem

Methanone, [4-(3-chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-

Ras/Erk activation,inhibit,Ras-induced transcription,Ras,refractory asthma,microtubules,XRP44X,Inhibitor

729605-21-4