XRP44X
- Product Name
- XRP44X
- CAS No.
- 729605-21-4
- Chemical Name
- XRP44X
- Synonyms
- XRP44X;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem;[4-(3-chlorophenyl)piperazin-1-yl]-(5-methyl-2-phenylpyrazol-3-yl)methanone;1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine;Piperazine,1-(3-chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]-;(4-(3-Chlorophenyl)piperazin-1-yl)(3-methyl-1-phenyl-1H-pyrazol-5-yl)methanone;[4-(3-Chlorophenyl)piperazin-1-yl](5-methyl-2-phenyl-2H-pyrazol-3-yl)methanone;[4-(3-Chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-methanone;Methanone, [4-(3-chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-
- CBNumber
- CB12502879
- Molecular Formula
- C21H21ClN4O
- Formula Weight
- 380.87
- MOL File
- 729605-21-4.mol
XRP44X Property
- Melting point:
- 136-140 0C
- Boiling point:
- 591.1±50.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: ≥20mg/mL
- pka
- 1.79±0.20(Predicted)
- form
- White solid
- color
- white to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 257135
- Product name
- XRP44X
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
- Product number
- X750960
- Product name
- XRP44X
- Packaging
- 100mg
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- B7276
- Product name
- XRP44X
- Packaging
- 50mg
- Price
- $1308
- Updated
- 2021/12/16
- Product number
- KIN0001258
- Product name
- XRP44X
- Purity
- 95.00%
- Packaging
- 0.05G
- Price
- $1340
- Updated
- 2021/12/16
- Product number
- 9763AF
- Product name
- XRP44X
- Packaging
- 10mg
- Price
- $997
- Updated
- 2021/12/16
XRP44X Chemical Properties,Usage,Production
Uses
XRP44X, is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.XRP44X is used as an anti-cancer drug targeting epidermal growth factor receptor.
Definition
ChEBI: [4-(3-chlorophenyl)-1-piperazinyl]-(5-methyl-2-phenyl-3-pyrazolyl)methanone is a member of piperazines.
General Description
A cell-permeable pyrazole compound that is shown to prevent in vitro tubulin polymerization (IC50 = 0.2 μM) by targeting Colchicine (Cat. No. 234115) binding site (Kd = 0.3 μM) in cell-free assays and induce blebs formation in HUVEC cultures by perturbing both tubulin microtubles and actin cytoskeleton structures. Unrelated to its effects on actin and tubulin filaments, XRP44X is also reported to block the activations of Ras and its downstream effector molecules, such as Raf, MEK, Erk, Rsk, and Net (Elk-3/SAP-2/Erp), upon FGF-2 (Cat. No. 341595) stimulation. Potently inhibits the growth of HUVEC, NIH3T3, as well as 9 other cancer cell lines in antiproliferation assays (IC50 ≤11.3 nM).
Biochem/physiol Actions
XRP44X is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.
XRP44X Preparation Products And Raw materials
Raw materials
Preparation Products
XRP44X Suppliers
- Tel
- --
- Fax
- --
- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
- 30