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Ristocetin A sulfate

Product Name
Ristocetin A sulfate
CAS No.
11140-99-1
Chemical Name
Ristocetin A sulfate
Synonyms
RISTON;SPONTIN;RISTOMYCIN;RISTOCETIN A;RISTOCETINSULFATQ;ristomycin,sulfate;RISTOCETIN SULFATE;RISTOCETIN A SULFATE;Ristocetin A sulphate;RISTOMYCIN MONOSULFATE
CBNumber
CB1251133
Molecular Formula
C95H112N8O48S
Formula Weight
2166
MOL File
11140-99-1.mol
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Ristocetin A sulfate Property

Melting point:
>200°C (dec.)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Water (Slightly)
form 
Light tan solid.
color 
White to Pale Beige
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
22-24/25-37/39-26
RIDADR 
3249
WGK Germany 
3
RTECS 
VJ8650000
8-10-23
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
mouse,LD50,intravenous,660mg/kg (660mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: OTHER CHANGESBEHAVIORAL: EXCITEMENT,Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. Vol. 32, Pg. 910, 1987.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R7752
Product name
Ristomycin monosulfate
Purity
≥90% ristocetinA basis (balance primarily RistocetinB)
Packaging
100mg
Price
$655
Updated
2024/03/01
Sigma-Aldrich
Product number
R7752
Product name
Ristomycin monosulfate
Purity
≥90% ristocetinA basis (balance primarily RistocetinB)
Packaging
250mg
Price
$1460
Updated
2024/03/01
Usbiological
Product number
R2032-22
Product name
Ristocetin A Sulfate
Packaging
10mg
Price
$513
Updated
2021/12/16
TRC
Product number
R530000
Product name
RistomycinMonosulfate(90%)
Packaging
1mg
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FR45311
Product name
Ristocetin sulfate - mixture of A & B
Packaging
5mg
Price
$73
Updated
2021/12/16
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Ristocetin A sulfate Chemical Properties,Usage,Production

Uses

Ristocetin A sulfate is a potent antibacterial glycopeptide antibiotic that was withdrawn from clinical use following a high incidence of thrombocytopenia. Further investigation found that ristocetin A induced platelet aggregation by binding to a factor absent in people suffering from von Willebrand's disease, leading to the use of ristocetin A as an important diagnostic aid.

Uses

Ristomycin Monosulfate is used in biological studies for ligand discovery of fluorescent HIV-1 Dimerization Initation Site.

General Description

Ristomycin/ristocetin is a type III glycopeptide. It is a highly glycosylated glycopeptide, previously found in?Amycolatopsis lurida.

Biological Activity

ristocetin a, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism nocardia lurida[1].ristocetin a is currently in clinical use to treat bacterial infections [1]. ristocetin a is an antibiotic which can be used to treat staphylococcal infections. the side effects of ristocetin a include thrombocytopenia and platelet agglutination. ristocetin a has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. these two assays could be used to diagnosis the von willebrand disease and other bleeding disorders [2, 3]. the structural features of ristocetin a are similar to vancomycin.

Biochem/physiol Actions

Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.

References

[1] pearson a j, heo j n. approaches to the fully functionalized def ring system of ristocetin a via highly selective ruthenium-promoted snar reaction[j]. organic letters, 2000, 2(19): 2987-2990.hawks g h. antibiotic therapy of staphylococcal infections[j]. canadian medical association journal, 1965, 93(16): 848.
[3] castaman, g. ,hillarp, a. and goodeve, a. laboratory aspects of von willebrand disease: test repertoire and options for activity assays and genetic analysis. haemophilia 20(suppl 4), 65-70 (2014).

Ristocetin A sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ristocetin A sulfate Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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010-65763397
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-400-6206333 18521732826
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021-50323701
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market@aladdin-e.com
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Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
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isunpharm@qq.com
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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Shanghai EFE Biological Technology Co., Ltd.
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parabiochem
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Greenherbs Science and Technology Development Co., Ltd.
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010-61136123
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+86 (10) 8857-9127
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Wuhan FengyaoTonghui Chemical Products Co., Ltd.
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027-87466105 15377573527
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2678564200@qq.com
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China
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View Lastest Price from Ristocetin A sulfate manufacturers

Career Henan Chemical Co
Product
RISTOCETIN SULFATE SALT 11140-99-1
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-15

11140-99-1, Ristocetin A sulfateRelated Search:


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  • Ristomycin, sulfate (salt)
  • RISTOCETINSULFATQ
  • Ristocetin A sulphate
  • SPONTIN
  • RISTOCETIN A
  • RISTOCETIN A SULFATE
  • RISTOCETIN SULFATE
  • RISTON
  • RISTOMYCIN MONOSULFATE SULFATE SALT
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  • RISTOCETIN SULFATE SALT
  • RISTOMYCIN
  • RISTOMYCIN MONOSULFATE
  • Ristocetin sulfate - mixture of A & B
  • Ristomycin Monosulfate (90%)
  • Ristomycin, sulfate (salt) (9CI, ACI)
  • 11140-99-1
  • C95H110N8O44H2SO4
  • C95H11N8O44
  • C95H112N8O44SO4
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics N-S
  • BioChemical