Ristocetin A sulfate
- Product Name
- Ristocetin A sulfate
- CAS No.
- 11140-99-1
- Chemical Name
- Ristocetin A sulfate
- Synonyms
- RISTON;SPONTIN;RISTOMYCIN;RISTOCETIN A;RISTOCETINSULFATQ;ristomycin,sulfate;RISTOCETIN SULFATE;RISTOCETIN A SULFATE;Ristocetin A sulphate;RISTOMYCIN MONOSULFATE
- CBNumber
- CB1251133
- Molecular Formula
- C95H112N8O48S
- Formula Weight
- 2166
- MOL File
- 11140-99-1.mol
Ristocetin A sulfate Property
- Melting point:
- >200°C (dec.)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Water (Slightly)
- form
- Light tan solid.
- color
- White to Pale Beige
- Stability:
- Hygroscopic
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/38
- Safety Statements
- 22-24/25-37/39-26
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- VJ8650000
- F
- 8-10-23
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- mouse,LD50,intravenous,660mg/kg (660mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: OTHER CHANGESBEHAVIORAL: EXCITEMENT,Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. Vol. 32, Pg. 910, 1987.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- R7752
- Product name
- Ristomycin monosulfate
- Purity
- ≥90% ristocetinA basis (balance primarily RistocetinB)
- Packaging
- 100mg
- Price
- $655
- Updated
- 2024/03/01
- Product number
- R7752
- Product name
- Ristomycin monosulfate
- Purity
- ≥90% ristocetinA basis (balance primarily RistocetinB)
- Packaging
- 250mg
- Price
- $1460
- Updated
- 2024/03/01
- Product number
- R2032-22
- Product name
- Ristocetin A Sulfate
- Packaging
- 10mg
- Price
- $513
- Updated
- 2021/12/16
- Product number
- R530000
- Product name
- RistomycinMonosulfate(90%)
- Packaging
- 1mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FR45311
- Product name
- Ristocetin sulfate - mixture of A & B
- Packaging
- 5mg
- Price
- $73
- Updated
- 2021/12/16
Ristocetin A sulfate Chemical Properties,Usage,Production
Uses
Ristocetin A sulfate is a potent antibacterial glycopeptide antibiotic that was withdrawn from clinical use following a high incidence of thrombocytopenia. Further investigation found that ristocetin A induced platelet aggregation by binding to a factor absent in people suffering from von Willebrand's disease, leading to the use of ristocetin A as an important diagnostic aid.
Uses
Ristomycin Monosulfate is used in biological studies for ligand discovery of fluorescent HIV-1 Dimerization Initation Site.
General Description
Ristomycin/ristocetin is a type III glycopeptide. It is a highly glycosylated glycopeptide, previously found in?Amycolatopsis lurida.
Biological Activity
ristocetin a, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism nocardia lurida[1].ristocetin a is currently in clinical use to treat bacterial infections [1]. ristocetin a is an antibiotic which can be used to treat staphylococcal infections. the side effects of ristocetin a include thrombocytopenia and platelet agglutination. ristocetin a has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. these two assays could be used to diagnosis the von willebrand disease and other bleeding disorders [2, 3]. the structural features of ristocetin a are similar to vancomycin.
Biochem/physiol Actions
Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.
References
[1] pearson a j, heo j n. approaches to the fully functionalized def ring system of ristocetin a via highly selective ruthenium-promoted snar reaction[j]. organic letters, 2000, 2(19): 2987-2990.hawks g h. antibiotic therapy of staphylococcal infections[j]. canadian medical association journal, 1965, 93(16): 848.
[3] castaman, g. ,hillarp, a. and goodeve, a. laboratory aspects of von willebrand disease: test repertoire and options for activity assays and genetic analysis. haemophilia 20(suppl 4), 65-70 (2014).
Ristocetin A sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ristocetin A sulfate manufacturers
- Product
- RISTOCETIN SULFATE SALT 11140-99-1
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-15