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MEPHENESIN

Product Name
MEPHENESIN
CAS No.
59-47-2
Chemical Name
MEPHENESIN
Synonyms
Rhex;Sinan;Tolax;Xeral;a1141;Ortol;A 1141;Daserd;Glytol;Mephin
CBNumber
CB5210066
Molecular Formula
C10H14O3
Formula Weight
182.22
MOL File
59-47-2.mol
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MEPHENESIN Property

Melting point:
69-71 °C(lit.)
Boiling point:
153-154 °C4 mm Hg(lit.)
Density 
1.0966 (rough estimate)
refractive index 
1.5320 (estimate)
Flash point:
153-154°C/4mm
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in alcohol
pka
13.52±0.20(Predicted)
form 
Solid
color 
White
Merck 
14,5850
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
2
RTECS 
TZ1225000
HS Code 
2909498090
Toxicity
LD50 in mice, rats, hamsters (mg/kg): 471, 283, 322 i.p.; 990, 945, 821 orally (Roszkowski); LD50 in mice (mM/kg): 2.83 i.p.; 10.53 orally (Dresel, Slater)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S423300
Product name
3-(ORTHO-TOLYLOXY)-1,2-PROPANEDIOL
Purity
Aldrich
Packaging
1g
Price
$179
Updated
2024/03/01
TCI Chemical
Product number
M3076
Product name
Mephenesin
Purity
>98.0%(GC)
Packaging
25g
Price
$31
Updated
2024/03/01
TRC
Product number
M225013
Product name
Mephenesin
Packaging
250mg
Price
$50
Updated
2021/12/16
Chem-Impex
Product number
38082
Product name
Mephenesin,≥98%(GC)
Purity
≥98%(GC)
Packaging
25G
Price
$43.1
Updated
2021/12/16
ChemScene
Product number
CS-5340
Product name
Mephenesin
Purity
99.20%
Packaging
500mg
Price
$50
Updated
2021/12/16
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MEPHENESIN Chemical Properties,Usage,Production

Originator

Tolserol,Squibb,US,1948

Uses

muscle relaxant (skeletal)

Uses

Mephenesin was used in the study of ligand-based virtual screening and design of antimalarial compounds.

Definition

ChEBI: 1-(2-methylphenyl)glycerol is a glycerol ether in which a single 2-methylphenyl group is attached at position 1 of glycerol via an ether linkage. It is an aromatic ether and a glycerol ether. It is functionally related to an o-cresol.

Manufacturing Process

Into an iron or copper reaction vessel having an efficient stirring device and furnished with a refluxing column and condenser, were charged 330 lb of high quality meta-cresol and 150 lb of glycerol, together with 25 lb of sodium acetate to serve as the catalyst in the reaction. The reaction mixture, of this composition, was then heated to 250°C. The water of the reaction distilled off during the heating as the ether formation proceeded, this removal of water from the reaction chamber being promoted by the presence of the excess of phenol, some of which also continued to distill over. Towards the end of the reaction, after about 12 hours, when about 60% of the glycerol had been converted, at which point the reaction slowed down and the distillate was mainly cresol, the batch was cooled and 50 gallons of water were added to it along with 150 lb of xylene. As the result of these additions and the cooling down of the material the batch stratified into an aqueous layer containing unreacted glycerol, polyglycerols and sodium acetate, and a nonaqueous layer containing the ethers that had been formed in the reaction, together with unreacted cresol which remained in the reaction chamber, dissolved in the xylene that had been added to the batch. The aqueous layer was then separated and the water content removed therefrom by evaporation to a degree suitable for the recovery of the glycerol and sodium acetate contents of the layer, for their reuse in the process in a succeeding batch therein. The separated nonaqueous layer containing the ethers was distilled to recover the xylene and cresol contents respectively as the early fractions of the layer thus subjected to distillation. The cresol thus recovered, together with the cresol recovered from the distillate obtained during the heating of the reaction mixture, was returned to the process for reuse in a succeeding batch. Redistillation of the ether mixture recovered is usually necessary and desirable, particularly from the point of view of removing last traces of cresol therefrom. The yield of mixed ethers in this example was about 200 lb, in the relative proportions stated of about 70 parts of monoether to 30 of diether.

brand name

Tolserol (Bristol-Myers Squibb);Bioglan m/q;Decontracyl-baum;Geno-sal;Glykresinum;Glyptol;Kencaps;Mefentil;Mepha-gesic;Mephesol;Midisalb-m;Myocalm;Myolisysin;Neo-xoline-m;Nochyrol;Relaxil-g;Rhex "hobein";Salimed compound;Walconesin.

Therapeutic Function

Muscle relaxant

World Health Organization (WHO)

Mephenesin, a centrally acting muscle relaxant and sedative, was introduced in 1948 and its use has subsequently been associated with some of the undesirable features of barbiturate use. It is of limited efficacy since it is shortacting and does not relieve the spasticity associated with chronic neurological disorders. It has therefore been largely superseded by benzodiazepines but it remains available in some countries.

MEPHENESIN Preparation Products And Raw materials

Raw materials

Preparation Products

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MEPHENESIN Suppliers

Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7195
Advantage
65
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from MEPHENESIN manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
MEPHENESIN 59-47-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-04
Hebei Chuanghai Biotechnology Co,.LTD
Product
MEPHENESIN 59-47-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000kg
Release date
2024-08-16
Hebei Mojin Biotechnology Co., Ltd
Product
MEPHENESIN 59-47-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-14

59-47-2, MEPHENESINRelated Search:


  • 1,2-Propanediol, 3-(2-methylphenoxy)-
  • 1,2-Propanediol, 3-(o-tolyloxy)-
  • 1-Ortho-tolylglycerol ether
  • 1-ortho-tolylglycerolether
  • 1-o-Tolylglycerol ether
  • 3-(2-Tolyloxy)-1,2-propanediol
  • 3-(o-Methylphenoxy)-1,2-propanediol
  • 3-(o-tolyloxy)-2-propanediol
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