NOVOBIOCIN SODIUM SALT

Product Name: NOVOBIOCIN SODIUM SALT
CAS No.: 1476-53-5
Chemical Name: NOVOBIOCIN SODIUM SALT
Synonyms: NOVOBIOCIN SODIUM;ALBAMYCIN;U-6591;Albadry;NSC 2382;Robicina;Vulcamycin;MSRV Selective;Albycin sodium;STREPTONIVICIN
CBNumber: CB9493214
Molecular Formula: C31H37N2NaO11
Formula Weight: 636.63
MOL File: 1476-53-5.mol

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NOVOBIOCIN SODIUM SALT Property

Melting point:: 215-220 C
alpha: D24 -38° (c = 2.5 in 95% ethanol); D24 -33° (c = 2.5 in water)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: H2O: soluble50mg/mL
form: White to yellow solid
color: white to faintly beige
PH: 7.5 (100g/l, H2O, 25℃)
optical activity: [α]20/D 48±3°, c = 1% in ethanol
Water Solubility: Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol.
Merck: 13,6755
BRN: 3892910
Stability:: Hygroscopic

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 43-36-36/37/38-20/21/22
Safety Statements: 36-36/37-26-37/39
WGK Germany: 2
RTECS: RD5425000
F: 8-10
HS Code: 2941 90 00
Toxicity: LD50 orally in Rabbit: 3500 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 491207
Product name: Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem
Purity: Novobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor that is used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases.
Packaging: 10g
Price: $289
Updated: 2024/03/01

Sigma-Aldrich

Product number: 46531
Product name: Novobiocin sodium salt
Purity: VETRANAL
Packaging: 250mg
Price: $101
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1.09874
Product name: MSRV Selective
Purity: supplement
Packaging: 10vial
Price: $204
Updated: 2024/03/01

Sigma-Aldrich

Product number: 491207
Product name: Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem
Purity: Novobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor that is used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases.
Packaging: 1g
Price: $50.5
Updated: 2022/05/15

Alfa Aesar

Product number: J60928
Product name: Novobiocin sodium salt
Packaging: 1g
Price: $47.9
Updated: 2024/03/01

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NOVOBIOCIN SODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

crystalline

Uses

Topoisomerase II inhibitorNovobiocin sodium salt is effective an antistaphylococcal agent used in the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). It is also used to inhibit the activity of retroviral RNA-dependent DNA polymerase as well as inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.

Uses

Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.

Uses

antibacterial

brand name

Albamycin (Pharmacia & Upjohn).

Biological Activity

Cell permeable: no', 'Primary Target
retrovirus RNA-dependent DNA polymerases', 'Product does not compete with ATP.', 'Reversible: no

Clinical Use

The action of novobiocin is largely bacteriostatic. Itsmode of action is not known with certainty, though it doesinhibit bacterial protein and nucleic acid synthesis. Studiesindicate that novobiocin and related coumarin-containingantibiotics bind to the subunit of DNA gyrase and possiblyinterfere with DNA supercoiling and energy transductionin bacteria. The effectiveness of novobiocin is confinedlargely to Gram-positive bacteria and a few strains of P. vulgaris.Its low activity against Gram-negative bacteria is apparentlybecause of poor cellular penetration.
Although cross-resistance to other antibiotics is reportednot to develop with novobiocin, resistant S. aureus strainsare known. Consequently, the medical use of novobiocin isreserved for the treatment of staphylococcal infections resistantto other antibiotics and sulfas and for patients allergicto these drugs. Another shortcoming that limits the usefulnessof novobiocin is the relatively high frequency ofadverse reactions, such as urticaria, allergic rashes, hepatotoxicity,and blood dyscrasias.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.

Purification Methods

The sodium salt has been recrystallised from MeOH, then dried at 60o/0.5mm. [Sensi et al, Anal Chem 29 1611 1957, Kaczka et al. J Am Chem Soc 78 4126 1956, Beilstein 18/8 IV 8125.]

NOVOBIOCIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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NOVOBIOCIN SODIUM SALT Suppliers

Canada 1 China 137 China Hong Kong 1 France 1 Germany 6 India 5 Japan 3 South Korea 1 Switzerland 4 United Kingdom 8 United States 37 Global 204

J & K SCIENTIFIC LTD.

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Adamas Reagent, Ltd.

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Beijing HuaMeiHuLiBiological Chemical

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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View Lastest Price from NOVOBIOCIN SODIUM SALT manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Novobiocin Sodium 1476-53-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Novobiocin Sodium 1476-53-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Career Henan Chemical Co

Product: NOVOBIOCIN SODIUM SALT 1476-53-5
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10MT
Release date: 2018-12-21

1476-53-5, NOVOBIOCIN SODIUM SALTRelated Search:

2-(Acetylamino)-3-phenyl-2-propenoic acid 4-HYDROXY-7-METHOXYCOUMARIN 4-METHOXY-3-METHYLBENZYL ALCOHOL Methyl 2-acetamidoacrylate 3-AMINOCOUMARIN NOVOBIOCIN SODIUM SALT MEPHENESIN 3-METHYLHIPPURIC ACID 6-Deoxy-L-glucose 4-METHOXY-4-METHYL-2-PENTANOL 2-Acetamidoacrylic acid Omethoate Sodium chloride Dimethoate 1-(2-METHYLPHENOXY)-2-PROPANOL Dehydro Phenylalanine (cis/trans Mixture) 2,4-Dimethoxy-3-methylbenzyl alcohol 2-(2,6-dimethylphenoxy)ethanamine

Novobiocin Sodium, >98%

MSRV Selective

Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem

Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-,sodium salt (1:1)

albamycin(capsule)

Albamycinsodium

Cathomycinsodium

Cathomycinsodiumlyovac

Monosodiumnovobiocin

Novobiocin,sodiumderiv.

Novobiocinmonosodium

N-[7-[(3-O-Carbamoyl-4-O,5-C-dimethyl-6-deoxy-β-L-lyxo-hexopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-sodiooxy-3-(3-methyl-2-butenyl)benzamide

Benzamide, N-7-3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-.alpha.-L-lyxo-hexopyranosyloxy-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt

7-[4-(Carbamoyloxy)-tetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yl]-4-hydroxy-3-[4-hydroxy-3-(3-methyl-2-butenyl)benzamido]-8-methyl-, sodium salt

Albadry

Albycin sodium

Antibiotic from streptomyces spheroides

Benzamide, N-[7-[[3-o-(aminocarbonyl)-6-deoxy-5-C-methyl-4-o-methyl-.beta.-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt

Novobiocin sodiuM(AlbaMycin)

N-[7-[[3-O-(AMinocarbonyl)-6-deoxy-5-C-Methyl-4-O-Methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-Methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-Methyl-2-butenyl)benzaMide MonosodiuM salt

NSC 2382

4-Hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl) benzamido]-8-methylcoumarin-7-yl 3-O-carbamoyl-5,5-di-C-methyl-α-L-lyxofuranoside sodium salt

Crystallinic acid MonosodiuM salt

Robicina

Novobiocin-Na-salt research grade

N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-benzamide, sodium salt (1:1)

Novobiocin Sodium (U-6591)

Sodiumalbamycin

Sodiumnovobiocin

Vulcamycin

MSRV SELECTIVE SUPPLEMENT

NOVOBIOCIN MONOSODIUM SALT

NOVOBIOCIN NA-SALT

NOVOBIOCIN SODIUM

NOVOBIOCIN SODIUM SALT

STREPTONIVICIN

U-6591

Novobiocin sodium salt, Antibiotic for Culture Media Use Only

ALBAMYCIN

novobiocin sodium crystalline

novobiocin sodium usp

NOVOBIOCIN SODIUM SALT VETRANAL, 250

NOVOBIOCINE MONOSODIUM FPC(CRM STANDARD)

NOVOBIOCIN SODIUM SALT APPOX. 90%

Novobiocin Sodium Salt Standard

Novobiocin sodium saL

Sodium 4-((7-(((2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)carbamoyl)-2-(3-methylbut-2-en-1-yl)phenolate

NOVOBIOCIN SODIUM SALT USP/EP/BP

Novobiocin Sodium Salt (NVB), 95%

Neomycin sodium salt

C15654200 Novobiocin sodium

Novobiocin Sodium, 10 mM in DMSO

1476-53-5

C31H35N2O11Na

C31H35N2NaO11

BioChemical

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