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NOVOBIOCIN SODIUM SALT

Product Name
NOVOBIOCIN SODIUM SALT
CAS No.
1476-53-5
Chemical Name
NOVOBIOCIN SODIUM SALT
Synonyms
NOVOBIOCIN SODIUM;ALBAMYCIN;U-6591;Albadry;NSC 2382;Robicina;Vulcamycin;MSRV Selective;Albycin sodium;STREPTONIVICIN
CBNumber
CB9493214
Molecular Formula
C31H37N2NaO11
Formula Weight
636.63
MOL File
1476-53-5.mol
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NOVOBIOCIN SODIUM SALT Property

Melting point:
215-220 C
alpha 
D24 -38° (c = 2.5 in 95% ethanol); D24 -33° (c = 2.5 in water)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: soluble50mg/mL
form 
White to yellow solid
color 
white to faintly beige
PH
7.5 (100g/l, H2O, 25℃)
optical activity
[α]20/D 48±3°, c = 1% in ethanol
Water Solubility 
Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol.
Merck 
13,6755
BRN 
3892910
Stability:
Hygroscopic
InChIKey
GSLZIJGIYIWATK-GEPKNSKANA-N
SMILES
CC1C(=CC=C2C(=C(NC(C3C=CC(O)=C(CC=C(C)C)C=3)=O)C(=O)OC=12)O)O[C@@H]1OC(C)(C)[C@H](OC)[C@@H](OC(=O)N)[C@H]1O.[NaH] |&1:29,34,37,42,r|
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
43-36-36/37/38-20/21/22
Safety Statements 
36-36/37-26-37/39
WGK Germany 
2
RTECS 
RD5425000
F 
8-10
HS Code 
2941 90 00
Toxicity
LD50 orally in Rabbit: 3500 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
491207
Product name
Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem
Purity
Novobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor that is used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases.
Packaging
10g
Price
$297
Updated
2025/07/31
Sigma-Aldrich
Product number
46531
Product name
Novobiocin sodium salt
Purity
VETRANAL
Packaging
250mg
Price
$103
Updated
2025/07/31
Sigma-Aldrich
Product number
1.09874
Product name
MSRV Selective
Purity
supplement
Packaging
10vial
Price
$212
Updated
2025/07/31
Sigma-Aldrich
Product number
491207
Product name
Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem
Purity
Novobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor that is used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases.
Packaging
1g
Price
$50.5
Updated
2022/05/15
Cayman Chemical
Product number
18457
Product name
Novobiocin (sodium salt)
Purity
≥95%
Packaging
1g
Price
$44
Updated
2024/03/01
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NOVOBIOCIN SODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

crystalline

Uses

Topoisomerase II inhibitorNovobiocin sodium salt is effective an antistaphylococcal agent used in the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). It is also used to inhibit the activity of retroviral RNA-dependent DNA polymerase as well as inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.

Uses

Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.

Uses

antibacterial

brand name

Albamycin (Pharmacia & Upjohn).

Biological Activity

Cell permeable: no', 'Primary Target
retrovirus RNA-dependent DNA polymerases', 'Product does not compete with ATP.', 'Reversible: no

Clinical Use

The action of novobiocin is largely bacteriostatic. Itsmode of action is not known with certainty, though it doesinhibit bacterial protein and nucleic acid synthesis. Studiesindicate that novobiocin and related coumarin-containingantibiotics bind to the subunit of DNA gyrase and possiblyinterfere with DNA supercoiling and energy transductionin bacteria. The effectiveness of novobiocin is confinedlargely to Gram-positive bacteria and a few strains of P. vulgaris.Its low activity against Gram-negative bacteria is apparentlybecause of poor cellular penetration.
Although cross-resistance to other antibiotics is reportednot to develop with novobiocin, resistant S. aureus strainsare known. Consequently, the medical use of novobiocin isreserved for the treatment of staphylococcal infections resistantto other antibiotics and sulfas and for patients allergicto these drugs. Another shortcoming that limits the usefulnessof novobiocin is the relatively high frequency ofadverse reactions, such as urticaria, allergic rashes, hepatotoxicity,and blood dyscrasias.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.

Purification Methods

The sodium salt has been recrystallised from MeOH, then dried at 60o/0.5mm. [Sensi et al, Anal Chem 29 1611 1957, Kaczka et al. J Am Chem Soc 78 4126 1956, Beilstein 18/8 IV 8125.]

NOVOBIOCIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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NOVOBIOCIN SODIUM SALT Suppliers

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View Lastest Price from NOVOBIOCIN SODIUM SALT manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
NOVOBIOCIN SODIUM SALT 1476-53-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-20
Zhuozhou Wenxi import and Export Co., Ltd
Product
Novobiocin Sodium 1476-53-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Novobiocin Sodium 1476-53-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

1476-53-5, NOVOBIOCIN SODIUM SALTRelated Search:

2-(Acetylamino)-3-phenyl-2-propenoic acid 4-HYDROXY-7-METHOXYCOUMARIN 4-METHOXY-3-METHYLBENZYL ALCOHOL Methyl 2-acetamidoacrylate 3-AMINOCOUMARIN NOVOBIOCIN SODIUM SALT MEPHENESIN 3-METHYLHIPPURIC ACID 6-Deoxy-L-glucose 4-METHOXY-4-METHYL-2-PENTANOL 2-Acetamidoacrylic acid Omethoate Sodium chloride Dimethoate 1-(2-METHYLPHENOXY)-2-PROPANOL Dehydro Phenylalanine (cis/trans Mixture) 2,4-Dimethoxy-3-methylbenzyl alcohol 2-(2,6-dimethylphenoxy)ethanamine

  • Novobiocin Sodium, >98%
  • MSRV Selective
  • Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem
  • Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-,sodium salt (1:1)
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  • Novobiocinmonosodium
  • N-[7-[(3-O-Carbamoyl-4-O,5-C-dimethyl-6-deoxy-β-L-lyxo-hexopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-sodiooxy-3-(3-methyl-2-butenyl)benzamide
  • Benzamide, N-7-3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-.alpha.-L-lyxo-hexopyranosyloxy-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt
  • 7-[4-(Carbamoyloxy)-tetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yl]-4-hydroxy-3-[4-hydroxy-3-(3-methyl-2-butenyl)benzamido]-8-methyl-, sodium salt
  • Albadry
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  • Antibiotic from streptomyces spheroides
  • Benzamide, N-[7-[[3-o-(aminocarbonyl)-6-deoxy-5-C-methyl-4-o-methyl-.beta.-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt
  • Novobiocin sodiuM(AlbaMycin)
  • N-[7-[[3-O-(AMinocarbonyl)-6-deoxy-5-C-Methyl-4-O-Methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-Methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-Methyl-2-butenyl)benzaMide MonosodiuM salt
  • NSC 2382
  • 4-Hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl) benzamido]-8-methylcoumarin-7-yl 3-O-carbamoyl-5,5-di-C-methyl-α-L-lyxofuranoside sodium salt
  • Crystallinic acid MonosodiuM salt
  • Robicina
  • Novobiocin-Na-salt research grade
  • N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-benzamide, sodium salt (1:1)
  • Novobiocin Sodium (U-6591)
  • Sodiumalbamycin
  • Sodiumnovobiocin
  • Vulcamycin
  • MSRV SELECTIVE SUPPLEMENT
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  • NOVOBIOCIN SODIUM
  • NOVOBIOCIN SODIUM SALT
  • STREPTONIVICIN
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  • Novobiocin Sodium Salt Standard
  • Novobiocin sodium saL
  • Sodium 4-((7-(((2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)carbamoyl)-2-(3-methylbut-2-en-1-yl)phenolate
  • NOVOBIOCIN SODIUM SALT USP/EP/BP
  • Novobiocin Sodium Salt (NVB), 95%
  • Neomycin sodium salt
  • C15654200 Novobiocin sodium
  • Novobiocin Sodium, 10 mM in DMSO
  • 4-[[7-(4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl)oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2-(3-methylbut-2-enyl)phenolate
  • Novobiocin Sodium (NSC 2382)
  • 1476-53-5
  • C31H35N2O11Na
  • C31H35N2NaO11
  • BioChemical