MEPHENESIN

ChemicalBook > CAS DataBase List > MEPHENESIN

Product Name: MEPHENESIN
CAS No.: 59-47-2
Chemical Name: MEPHENESIN
Synonyms: Rhex;Sinan;Tolax;Xeral;a1141;Ortol;A 1141;Daserd;Glytol;Mephin
CBNumber: CB5210066
Molecular Formula: C10H14O3
Formula Weight: 182.22
MOL File: 59-47-2.mol

Less

MEPHENESIN Property

Melting point:: 69-71 °C(lit.)
Boiling point:: 153-154 °C4 mm Hg(lit.)
Density: 1.0966 (rough estimate)
refractive index: 1.5320 (estimate)
Flash point:: 153-154°C/4mm
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in alcohol
pka: 13.52±0.20(Predicted)
form: Solid
color: White
Merck: 14,5850

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 2
RTECS: TZ1225000
HS Code: 2909498090
Toxicity: LD50 in mice, rats, hamsters (mg/kg): 471, 283, 322 i.p.; 990, 945, 821 orally (Roszkowski); LD50 in mice (mM/kg): 2.83 i.p.; 10.53 orally (Dresel, Slater)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S423300
Product name: 3-(ORTHO-TOLYLOXY)-1,2-PROPANEDIOL
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: M3076
Product name: Mephenesin
Purity: >98.0%(GC)
Packaging: 25g
Price: $31
Updated: 2024/03/01

TRC

Product number: M225013
Product name: Mephenesin
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Chem-Impex

Product number: 38082
Product name: Mephenesin,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 25G
Price: $43.1
Updated: 2021/12/16

ChemScene

Product number: CS-5340
Product name: Mephenesin
Purity: 99.20%
Packaging: 500mg
Price: $50
Updated: 2021/12/16

Less

MEPHENESIN Chemical Properties,Usage,Production

Originator

Tolserol,Squibb,US,1948

Uses

muscle relaxant (skeletal)

Uses

Mephenesin was used in the study of ligand-based virtual screening and design of antimalarial compounds.

Definition

ChEBI: 1-(2-methylphenyl)glycerol is a glycerol ether in which a single 2-methylphenyl group is attached at position 1 of glycerol via an ether linkage. It is an aromatic ether and a glycerol ether. It is functionally related to an o-cresol.

Manufacturing Process

Into an iron or copper reaction vessel having an efficient stirring device and furnished with a refluxing column and condenser, were charged 330 lb of high quality meta-cresol and 150 lb of glycerol, together with 25 lb of sodium acetate to serve as the catalyst in the reaction. The reaction mixture, of this composition, was then heated to 250°C. The water of the reaction distilled off during the heating as the ether formation proceeded, this removal of water from the reaction chamber being promoted by the presence of the excess of phenol, some of which also continued to distill over. Towards the end of the reaction, after about 12 hours, when about 60% of the glycerol had been converted, at which point the reaction slowed down and the distillate was mainly cresol, the batch was cooled and 50 gallons of water were added to it along with 150 lb of xylene. As the result of these additions and the cooling down of the material the batch stratified into an aqueous layer containing unreacted glycerol, polyglycerols and sodium acetate, and a nonaqueous layer containing the ethers that had been formed in the reaction, together with unreacted cresol which remained in the reaction chamber, dissolved in the xylene that had been added to the batch. The aqueous layer was then separated and the water content removed therefrom by evaporation to a degree suitable for the recovery of the glycerol and sodium acetate contents of the layer, for their reuse in the process in a succeeding batch therein. The separated nonaqueous layer containing the ethers was distilled to recover the xylene and cresol contents respectively as the early fractions of the layer thus subjected to distillation. The cresol thus recovered, together with the cresol recovered from the distillate obtained during the heating of the reaction mixture, was returned to the process for reuse in a succeeding batch. Redistillation of the ether mixture recovered is usually necessary and desirable, particularly from the point of view of removing last traces of cresol therefrom. The yield of mixed ethers in this example was about 200 lb, in the relative proportions stated of about 70 parts of monoether to 30 of diether.

brand name

Tolserol (Bristol-Myers Squibb);Bioglan m/q;Decontracyl-baum;Geno-sal;Glykresinum;Glyptol;Kencaps;Mefentil;Mepha-gesic;Mephesol;Midisalb-m;Myocalm;Myolisysin;Neo-xoline-m;Nochyrol;Relaxil-g;Rhex "hobein";Salimed compound;Walconesin.

Therapeutic Function

Muscle relaxant

World Health Organization (WHO)

Mephenesin, a centrally acting muscle relaxant and sedative, was introduced in 1948 and its use has subsequently been associated with some of the undesirable features of barbiturate use. It is of limited efficacy since it is shortacting and does not relieve the spasticity associated with chronic neurological disorders. It has therefore been largely superseded by benzodiazepines but it remains available in some countries.

MEPHENESIN Preparation Products And Raw materials

Raw materials

Preparation Products

Less

MEPHENESIN Suppliers

Americas 1 China 71 Europe 3 Germany 2 India 13 Japan 1 Switzerland 1 United Kingdom 3 United States 22 Global 117

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 6791
Advantage: 65

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4674
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11662
Advantage: 59

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29764
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19800
Advantage: 60

Aikon International Limited

Tel: 025-66113011 18112977050
Fax: (5)02557626880
Email: cb6@aikonchem.com
Country: China
ProdList: 15494
Advantage: 58

Conier Chem & Pharma Limited

Tel: 13368167990
Email: sales@conier.com
Country: China
ProdList: 2839
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6037 18920794737
Email: sales@heowns.com
Country: China
ProdList: 23083
Advantage: 60

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-010-010-62971590 18548936886
Fax: 010-62340519
Email: jack@oka-vip.com
Country: China
ProdList: 6897
Advantage: 58

Shenzhen Botel Biotechnology Co. Ltd.

Tel: 0755-22202135 13316968096
Email: 1979313431@qq.com
Country: China
ProdList: 9120
Advantage: 58

TCI Chemicals

Tel: 021-67121386, 800-988-0390
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 5391
Advantage: 58

Zhengzhou Alfa Chemical Co.,Ltd

Tel: +8618530059196
Email: sale04@alfachem.cn
Country: China
ProdList: 11915
Advantage: 58

Hebei Mujin Biotechnology Co.,Ltd

Tel: +86 13288715578 +8613288715578
Email: sales@hbmojin.com
Country: China
ProdList: 12830
Advantage: 58

Hebei Chuanghai Biotechnology Co,.LTD

Tel: +86-13131129325
Fax: 86-0311-66562153
Email: sales1@chuanghaibio.com
Country: China
ProdList: 5887
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15352
Advantage: 58

HUNAN CHEMFISH SCIENTIFIC CO.,LTD

Tel: +86-0731-85567275 18932438858
Fax: QQ:3554193828
Email: sales05@chemfish.com
Country: China
ProdList: 8340
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Hebei Weibang Biotechnology Co., Ltd

Tel: +8615531157085
Fax: whatapp+8619930503282
Email: abby@weibangbio.com
Country: China
ProdList: 8804
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39894
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Zhongxin Chenshi (Wuhan) Technology Co., Ltd

Tel: 18942922096
Fax: QQ 2662561040
Email: 2662561040@qq.com
Country: China
ProdList: 1001
Advantage: 58

CHG Opto-Electronic Corporation Limited

Tel: 2537653158 16621191650
Fax: QQ 2537653158
Email: 2537653158@qq.com
Country: China
ProdList: 7140
Advantage: 58

Wuhan ShuEr Biology Technology Co.,Ltd

Tel: 027-15827133616-6 15827133616
Fax: QQ 1799696397
Email: 1799696397@qq.com
Country: China
ProdList: 2852
Advantage: 58

Hubei Qifei Pharmaceutical Chemical Co., Ltd

Tel: 027-027-59322506 18071128681
Fax: 027-59322506
Email: 1438082200@qq.com
Country: China
ProdList: 9975
Advantage: 58

Hubei Zhonglong Kangsheng fine chemical Co.,Ltd

Tel: 027-027-82752821 18186694582
Fax: 027-82752821
Email: 323495346@qq.com
Country: China
ProdList: 3584
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-029-81124267 15229202216
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 9923
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 17730
Advantage: 58

Henan Evonik Biotechnology Co. LTD

Tel: 17837010661
Email: 2224986086@qq.com
Country: China
ProdList: 4787
Advantage: 58

Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 9122
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 4997
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 18021050169
Email: market@aladdin-e.com
Country: China
ProdList: 48461
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9266
Advantage: 58

Tianjin Rongshen Chemical Co., Ltd

Tel: 18317763565
Email: 18317763565@163.com
Country: China
ProdList: 8675
Advantage: 58

Tel
Email: sangon@qq.com
Country: CHINA
ProdList: 47239
Advantage: 58

Less

View Lastest Price from MEPHENESIN manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: MEPHENESIN 59-47-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-14

Hebei Weibang Biotechnology Co., Ltd

Product: MEPHENESIN 59-47-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-04

Hebei Chuanghai Biotechnology Co,.LTD

Product: MEPHENESIN 59-47-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000kg
Release date: 2024-08-16

59-47-2, MEPHENESINRelated Search:

NOVOBIOCIN SODIUM SALT Phlorizin NAPHTHOL AS-BI BETA-D-GLUCURONIDE POPULIN MEPHENESIN HELICIN Cromolyn Disodium Salt Novobiocin D-(-)-Salicin CARTHAMUS YELLOW NAPHTHOL AS-BI BETA-D-GALACTOPYRANOSIDE 4-CHLORO-2-CYCLOPENTYLPHENYL-BETA-D-GALACTOPYRANOSIDE 7-[3-(4-ACETYL-3-HYDROXY-2-PROPYLPHENOXY)-2-HYDROXYPROPOXY]-4-OXO-8-PROPYL-4H-1-BENZOPYRAN-2-CARBOXYLIC ACID SODIUM SALT 2-(BETA-D-GALACTOSIDOXY)NAPHTHOL AS-LC RHEIN-8-GLUCOSIDE Ristocetin A sulfate NAPHTHOL AS-BI BETA-L-FUCOPYRANOSIDE 4'-Deoxyphlorizin

1,2-Propanediol, 3-(2-methylphenoxy)-

1,2-Propanediol, 3-(o-tolyloxy)-

1-Ortho-tolylglycerol ether

1-ortho-tolylglycerolether

1-o-Tolylglycerol ether

3-(2-Tolyloxy)-1,2-propanediol

3-(o-Methylphenoxy)-1,2-propanediol

3-(o-tolyloxy)-2-propanediol

3-(o-Tolyloxy)propane-1,2-diol

A 1141

Cresossipropandiolo

Cresoxydiol

Curaril

Curarythan

Curythan

Daserd

Daserol

Decontractil

Decontractyl

Diloxol

Dioloxal

Dioloxol

Findolar

Findolor

Glukresin

Glyceryl o-Tolyl ether

glycerylo-tolylether

Glykresin

Glyotol

Glytol

Halabar

Kinavosyl

Kresoxypropandiol

Lissenphan

Lissephen

Mc 2303

Mefenesina

Mefensina

Memphenesin

Mephate

Mephedan

Mephelor

Mephenesine

Mephensin

Mepherol

Mephesin

Mephin

Mephosal

Mephson

Mervaldin

Mianesina

Miolisina

Moctynol

Myanesin

Myanil

Myanol

Myasin

Myastenin