ChemicalBook > CAS DataBase List > MEPHENESIN

MEPHENESIN

Product Name: MEPHENESIN
CAS No.: 59-47-2
Chemical Name: MEPHENESIN
Synonyms: Rhex;Sinan;Tolax;Xeral;a1141;Ortol;A 1141;Daserd;Glytol;Mephin
CBNumber: CB5210066
Molecular Formula: C10H14O3
Formula Weight: 182.22
MOL File: 59-47-2.mol

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MEPHENESIN Property

Melting point:: 69-71 °C(lit.)
Boiling point:: 153-154 °C4 mm Hg(lit.)
Density: 1.0966 (rough estimate)
refractive index: 1.5320 (estimate)
Flash point:: 153-154°C/4mm
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in alcohol
pka: 13.52±0.20(Predicted)
form: Solid
color: White
Merck: 14,5850

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 2
RTECS: TZ1225000
HS Code: 2909498090
Toxicity: LD50 in mice, rats, hamsters (mg/kg): 471, 283, 322 i.p.; 990, 945, 821 orally (Roszkowski); LD50 in mice (mM/kg): 2.83 i.p.; 10.53 orally (Dresel, Slater)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S423300
Product name: 3-(ORTHO-TOLYLOXY)-1,2-PROPANEDIOL
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S423300
Product name: 3-(ORTHO-TOLYLOXY)-1,2-PROPANEDIOL
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: M3076
Product name: Mephenesin
Purity: >98.0%(GC)
Packaging: 25g
Price: $31
Updated: 2025/07/31

TRC

Product number: M225013
Product name: Mephenesin
Packaging: 250mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: J56551
Product name: Mephenesin
Packaging: 1g
Price: $15
Updated: 2021/12/16

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MEPHENESIN Chemical Properties,Usage,Production

Originator

Tolserol,Squibb,US,1948

Uses

muscle relaxant (skeletal)

Uses

Mephenesin was used in the study of ligand-based virtual screening and design of antimalarial compounds.

Definition

ChEBI: 1-(2-methylphenyl)glycerol is a glycerol ether in which a single 2-methylphenyl group is attached at position 1 of glycerol via an ether linkage. It is an aromatic ether and a glycerol ether. It is functionally related to an o-cresol.

Manufacturing Process

Into an iron or copper reaction vessel having an efficient stirring device and furnished with a refluxing column and condenser, were charged 330 lb of high quality meta-cresol and 150 lb of glycerol, together with 25 lb of sodium acetate to serve as the catalyst in the reaction. The reaction mixture, of this composition, was then heated to 250°C. The water of the reaction distilled off during the heating as the ether formation proceeded, this removal of water from the reaction chamber being promoted by the presence of the excess of phenol, some of which also continued to distill over. Towards the end of the reaction, after about 12 hours, when about 60% of the glycerol had been converted, at which point the reaction slowed down and the distillate was mainly cresol, the batch was cooled and 50 gallons of water were added to it along with 150 lb of xylene. As the result of these additions and the cooling down of the material the batch stratified into an aqueous layer containing unreacted glycerol, polyglycerols and sodium acetate, and a nonaqueous layer containing the ethers that had been formed in the reaction, together with unreacted cresol which remained in the reaction chamber, dissolved in the xylene that had been added to the batch. The aqueous layer was then separated and the water content removed therefrom by evaporation to a degree suitable for the recovery of the glycerol and sodium acetate contents of the layer, for their reuse in the process in a succeeding batch therein. The separated nonaqueous layer containing the ethers was distilled to recover the xylene and cresol contents respectively as the early fractions of the layer thus subjected to distillation. The cresol thus recovered, together with the cresol recovered from the distillate obtained during the heating of the reaction mixture, was returned to the process for reuse in a succeeding batch. Redistillation of the ether mixture recovered is usually necessary and desirable, particularly from the point of view of removing last traces of cresol therefrom. The yield of mixed ethers in this example was about 200 lb, in the relative proportions stated of about 70 parts of monoether to 30 of diether.

brand name

Tolserol (Bristol-Myers Squibb);Bioglan m/q;Decontracyl-baum;Geno-sal;Glykresinum;Glyptol;Kencaps;Mefentil;Mepha-gesic;Mephesol;Midisalb-m;Myocalm;Myolisysin;Neo-xoline-m;Nochyrol;Relaxil-g;Rhex "hobein";Salimed compound;Walconesin.

Therapeutic Function

Muscle relaxant

World Health Organization (WHO)

Mephenesin, a centrally acting muscle relaxant and sedative, was introduced in 1948 and its use has subsequently been associated with some of the undesirable features of barbiturate use. It is of limited efficacy since it is shortacting and does not relieve the spasticity associated with chronic neurological disorders. It has therefore been largely superseded by benzodiazepines but it remains available in some countries.

References

[1] Chemical Communications, 2013, vol. 49, # 52, p. 5886 - 5888
[2] Patent: KR2015/74160, 2015, A. Location in patent: Paragraph 0158-0160

MEPHENESIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MEPHENESIN manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: MEPHENESIN 59-47-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-04

Hebei Chuanghai Biotechnology Co,.LTD

Product: MEPHENESIN 59-47-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000kg
Release date: 2024-08-16

Career Henan Chemical Co

Product: MEPHENESIN 59-47-2
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-12

59-47-2, MEPHENESINRelated Search:

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1,2-Propanediol, 3-(2-methylphenoxy)-

1,2-Propanediol, 3-(o-tolyloxy)-

1-Ortho-tolylglycerol ether

1-ortho-tolylglycerolether

1-o-Tolylglycerol ether

3-(2-Tolyloxy)-1,2-propanediol

3-(o-Methylphenoxy)-1,2-propanediol

3-(o-tolyloxy)-2-propanediol

3-(o-Tolyloxy)propane-1,2-diol

A 1141

Cresossipropandiolo

Cresoxydiol

Curaril

Curarythan

Curythan

Daserd

Daserol

Decontractil

Decontractyl

Diloxol

Dioloxal

Dioloxol

Findolar

Findolor

Glukresin

Glyceryl o-Tolyl ether

glycerylo-tolylether

Glykresin

Glyotol

Glytol

Halabar

Kinavosyl

Kresoxypropandiol

Lissenphan

Lissephen

Mc 2303

Mefenesina

Mefensina

Memphenesin

Mephate

Mephedan

Mephelor

Mephenesine

Mephensin

Mepherol

Mephesin

Mephin

Mephosal

Mephson

Mervaldin

Mianesina

Miolisina

Moctynol

Myanesin

Myanil

Myanol

Myasin

Myastenin