ChemicalBook > CAS DataBase List > 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester

3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester

Product Name
3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester
CAS No.
1014691-61-2
Chemical Name
3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester
Synonyms
CS-738;GSK 0660;GSK-0660, >=98%;GSK-0660 (GSK0660);GSK0660 >=98% (HPLC);GSK0660, 10 mM in DMSO;GSK-0660;GSK 0660;GSK0660;GSK 0660, PPARdelta antagonist;4-Chloro-3-iodo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine;METHYL 3-[(4-ANILINO-2-METHOXYPHENYL)SULFAMOYL]THIOPHENE-2-CARBOXYLATE
CBNumber
CB12518768
Molecular Formula
C19H18N2O5S2
Formula Weight
418.49
MOL File
1014691-61-2.mol
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3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Property

Boiling point:
608.1±65.0 °C(Predicted)
Density 
1.413±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
8.51±0.50(Predicted)
color 
white to beige
InChI
InChI=1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3
InChIKey
NDFKBGWLUHKMFY-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)SC=CC=1S(NC1=CC=C(NC2=CC=CC=C2)C=C1OC)(=O)=O
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Safety

WGK Germany 
2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G5797
Product name
GSK0660
Purity
≥98% (HPLC)
Packaging
5mg
Price
$153
Updated
2022/05/15
Cayman Chemical
Product number
15272
Product name
GSK0660
Purity
≥95%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
15272
Product name
GSK0660
Purity
≥95%
Packaging
10mg
Price
$182
Updated
2024/03/01
Cayman Chemical
Product number
15272
Product name
GSK0660
Purity
≥95%
Packaging
25mg
Price
$427
Updated
2024/03/01
Cayman Chemical
Product number
15272
Product name
GSK0660
Purity
≥95%
Packaging
50mg
Price
$711
Updated
2024/03/01
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3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Chemical Properties,Usage,Production

Uses

GSK0660 has been used to study the effects of bezafibrate (BZA) on hypertrophy.

Definition

ChEBI: 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]-2-thiophenecarboxylic acid methyl ester is a sulfonamide.

General Description

GSK0660 has antiangiogenic property in oxygen-induced retinopathy. It also regulates tumor necrosis factor-α (TNFα)-induced inflammation in human retinal microvascular endothelial cells (HRMECs).

Biochem/physiol Actions

GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8 (160 nM). GSK0660 is nearly inactive on PPARα and PPARγ with IC50s greater than 10 μM.

storage

Store at +4°C

3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Suppliers

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View Lastest Price from 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester manufacturers

Career Henan Chemical Co
Product
methyl 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]thiophene-2-carboxylate 1014691-61-2
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

1014691-61-2, 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylesterRelated Search:

Entospletinib (GS-9973) GS9620 GSK2643943A GS967 GSK J1 GSK-114 GSK-626616 Selonsertib Presatovir 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE

  • GSK-0660, >=98%
  • 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester
  • GSK 0660
  • Methyl 3-(N-(2-Methoxy-4-(phenylaMino)phenyl)sulfaMoyl)thiophene-2-carboxylate
  • 2-Thiophenecarboxylic acid, 3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-, methyl ester
  • 4-Chloro-3-iodo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
  • METHYL 3-[(4-ANILINO-2-METHOXYPHENYL)SULFAMOYL]THIOPHENE-2-CARBOXYLATE
  • 3-(2-Methoxy-4-phenylamino-phenylsulfamoyl)-thiophene-2-carboxylic acid methyl ester
  • CS-738
  • GSK-0660 (GSK0660)
  • GSK-0660;GSK 0660;GSK0660
  • GSK0660 >=98% (HPLC)
  • methyl 3-{[2-methoxy-4-(phenylamino)phenyl]sulfamoyl}thiophene-2-carboxylate
  • GSK 0660, PPARdelta antagonist
  • GSK0660, 10 mM in DMSO
  • 1014691-61-2
  • Inhibitors