2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide

Product Name: 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide
CAS No.: 474960-44-6
Chemical Name: 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide
Synonyms: CS-1139;SB 657510;SB 657510,SB657510;SB-657510, 10 mM in DMSO;(R)-2-Bromo-N-(4-chloro-3-((1-methylpyrrolidin-3-yl)oxy)phenyl)-4,5-dimethoxybenzenesulfonamide;2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide;2-bromo-N-[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxy-phenyl]-4,5-dimethoxy-benzenesulfonamide;BenzenesulfonaMide, 2-broMo-N-[4-chloro-3-[[(3R)-1-Methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-diMethoxy-
CBNumber: CB12518915
Molecular Formula: C19H22BrClN2O5S
Formula Weight: 505.81
MOL File: 474960-44-6.mol

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2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide Property

Boiling point:: 585.0±60.0 °C(Predicted)
Density: 1.512±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO: ≥30mg/mL
pka: 6.60±0.10(Predicted)
form: powder
color: white to off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7326
Product name: SB 657510
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $160
Updated: 2025/07/31

Sigma-Aldrich

Product number: S7326
Product name: SB 657510
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $632
Updated: 2025/07/31

TRC

Product number: S155043
Product name: SB 657510
Packaging: 25mg
Price: $185
Updated: 2021/12/16

ChemScene

Product number: CS-0002710
Product name: SB 657510
Purity: 99.76%
Packaging: 1mg
Price: $155
Updated: 2021/12/16

ApexBio Technology

Product number: B7432
Product name: SB 657510
Packaging: 10mg
Price: $329
Updated: 2021/12/16

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2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide Chemical Properties,Usage,Production

Uses

SB 657510 is a selective GPR14 (urotensin-II (UT) receptor) antagonist.

Biological Activity

SB 657510 slows development of diabetes-associated atherosclerosis in mouse model of diabetes.1 ', 'SB-657510 is a selective urotensin-II (UT) receptor antagonist. Human urotensin-II (hU-II) is proposed to play a significant role in cardiorenal and metabolic disease states, including heart failure, atherosclerosis, hypertension.

in vivo

SB-657510 inhibits the progression of high-fat diet induced atherosclerosis and diabetes-associated atherosclerosis^[1].
Levels of phosphorylated ERK are significantly attenuated in the aorta of SB-657510-treated (30 mg/kg/day) diabetic mice (Male Apoe KO mice)^[3].

2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide Suppliers

China 39 United Kingdom 2 United States 10 USA 1 Global 52

EMMX Biotechnology LLC

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474960-44-6, 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamideRelated Search:

N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide

CS-1139

SB 657510

BenzenesulfonaMide, 2-broMo-N-[4-chloro-3-[[(3R)-1-Methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-diMethoxy-

2-bromo-N-[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxy-phenyl]-4,5-dimethoxy-benzenesulfonamide

SB 657510,SB657510

(R)-2-Bromo-N-(4-chloro-3-((1-methylpyrrolidin-3-yl)oxy)phenyl)-4,5-dimethoxybenzenesulfonamide

SB-657510, 10 mM in DMSO

474960-44-6

C19H22BrClN2O5S

C19H22BrCIN2O5S