N1-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE
- Product Name
- N1-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE
- CAS No.
- 25892-08-4
- Chemical Name
- N1-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE
- Synonyms
- N-(2,6-Difluoro-3-nitrophenyl);N-(2,6-Difluoro-3-nitrophenyl)acetaMid;N-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE;N1-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE;Acetamide, N-(2,6-difluoro-3-nitrophenyl)-;N1-(2,6-difluoro-3-nitrophenyl)acetamide 95+%
- CBNumber
- CB1252600
- Molecular Formula
- C8H6F2N2O3
- Formula Weight
- 216.14
- MOL File
- 25892-08-4.mol
N1-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE Property
- Melting point:
- 148 °C
- Boiling point:
- 352.7±42.0 °C(Predicted)
- Density
- 1.513±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.03±0.70(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2924297099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D451180
- Product name
- N-(2,6-Difluoro-3-nitrophenyl)acetamide
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 074736
- Product name
- N-(2,6-Difluoro-3-nitrophenyl)acetamide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $268
- Updated
- 2021/12/16
- Product number
- FD105530
- Product name
- N-(2,6-difluoro-3-nitrophenyl)acetamide
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FD105530
- Product name
- N-(2,6-difluoro-3-nitrophenyl)acetamide
- Packaging
- 2g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- W4923
- Product name
- N-(2,6-Difluoro-3-nitro-phenyl)-acetamide
- Packaging
- 10g
- Price
- $617
- Updated
- 2021/12/16
N1-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE Chemical Properties,Usage,Production
Synthesis
3896-29-5
25892-08-4
1. cool sulfuric acid (53.3 mL, 760 mmol) in an ice-water bath and slowly add nitric acid (25.6 mL, 610 mmol), keeping the temperature below 10°C. 2. add N-(2,6-difluorophenyl)acetamide (13.0 g, 76.0 mmol) to the mixed acid solution. 2. N-(2,6-difluorophenyl)acetamide (13.0 g, 76.0 mmol) was added to the above mixed acid solution in batches, ensuring that the reaction temperature was maintained at room temperature. 3. The reaction mixture was stirred at room temperature for 18 hours to carry out the nitration reaction. 4. Upon completion of the reaction, the mixture was slowly poured into ice water to precipitate a yellow solid. 5. The precipitate was collected by filtration and the solid residue was washed well with cold water. 6. The product was dried over air to give 2,6-difluoro-3-nitro-acetanilide (11.2 g, 51.8 mmol, 68% yield) as a yellow solid. 7. The product was analyzed by LCMS (1:1). 7. The product was characterized by LCMS (ESI, cationic mode): calculated C8H6F2N2O3 [M+H]+ 216.0, measured 217.2. 8. 1H NMR (ESI, cationic mode) was performed on the product. 8. 1H NMR (300 MHz, DMSO-d6) δ ppm: 10.04 (br s, 1H, NH), 8.02-8.28 (m, 1H, ArH), 7.44 (td, J = 9.1, 1.8 Hz, 1H, ArH), 2.11 (s, 3H, CH3).
References
[1] Journal of Chemical Research, 2004, # 10, p. 699 - 701
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 10, p. 2215 - 2234
[3] Patent: WO2012/85127, 2012, A1. Location in patent: Page/Page column 39
[4] Patent: WO2012/101238, 2012, A1. Location in patent: Page/Page column 38
[5] Patent: US2012/322803, 2012, A1. Location in patent: Page/Page column 17
N1-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N1-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE manufacturers
- Product
- N1-(2,6-DIFLUORO-3-NITROPHENYL)ACETAMIDE 25892-08-4
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02