ChemicalBook > CAS DataBase List > N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine

Product Name
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
CAS No.
444731-74-2
Chemical Name
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
Synonyms
BNKY007-PZ01;Pazopanib Impurity 20;2H-indazol-6aMine,2,3-diMethyl.HCl(1:1);N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-;6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole;N-(2-chloropyrimidin-4-yl)-N,2,3-dimethyl-2H-indazol -6-amine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine ISO 9001：2015 REACH
CBNumber
CB12526161
Molecular Formula
C13H12ClN5
Formula Weight
273.72
MOL File
444731-74-2.mol
More
Less

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Property

Melting point:
>216oC (dec.)
Boiling point:
550.0±35.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
2.56±0.30(Predicted)
color 
Pale Orange to Light Brown
Stability:
Hygroscopic
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
C380080
Product name
N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine
Packaging
1g
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC32848
Product name
N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine
Packaging
250mg
Price
$315
Updated
2021/12/16
Matrix Scientific
Product number
095743
Product name
N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine
Purity
95+%
Packaging
250mg
Price
$439
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC32848
Product name
N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine
Packaging
500mg
Price
$525
Updated
2021/12/16
AK Scientific
Product number
X3179
Product name
N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine
Packaging
5g
Price
$728
Updated
2021/12/16
More
Less

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Chemical Properties,Usage,Production

Uses

N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine (N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine) is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Application

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine is a valuable organic compound that could be used to synthesize N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, N- (2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, and others.

Synthesis

2,3-dimethyl-6-amino-2H- indazole 5.00g,2,4-Dichloropyrimidine 13.9g and sodium bicarbonate 10.4g were dissolved in 100mL absolute ethanol and heated to 79°C.After refluxing for 4 h, cool to room temperature and filter. The cake was washed well with ethyl acetate, and the filtrate was collected. Concentrate under reduced pressure, remove the solvent, and fully beat with ethyl acetate and filter to give an off-white solid. Recrystallization from methanol gave 7.64 g of product N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine as a white solid, yield: 90.0%.

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Suppliers

Canada 1 China 114 India 9 United Kingdom 1 United States 8 Global 133
More
Less

View Lastest Price from N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine 444731-74-2
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-23
Career Henan Chemical Co
Product
2H-Indazol-6-amine,N-(2-chloro-4-pyrimidinyl)-2,3-dimethyl- 444731-74-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20tons
Release date
2018-08-13

444731-74-2, N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amineRelated Search:

Pazopanib Related Compound 3 (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Pazopanib Impurity 9 N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE Pazopanib Pazopanib-d6 2,3-dimethyl-2H-indazol-6-amine hydrochloride Pazopanib Related Compound 2 1,3-Dimethyl-6-nitro-1H-indazole 2-Methyl-5-nitrobenzenesulfonamide 3-AMINO-4-METHYLBENZENESULFONAMIDE 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) 1,3-DiMethyl-6-aMino-1H-indazole 4(1H)-Pyrimidinone, 2-chloro- (9CI) Pazopanib Impurity 10

  • N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
  • 2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-
  • N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine
  • N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine
  • 2H-indazol-6aMine,2,3-diMethyl.HCl(1:1)
  • 6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole
  • Pazopanib Impurity 20
  • BNKY007-PZ01
  • N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine ISO 9001：2015 REACH
  • N-(2-chloropyrimidin-4-yl)-N,2,3-dimethyl-2H-indazol -6-amine
  • 444731-74-2