N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
- Product Name
- N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
- CAS No.
- 444731-74-2
- Chemical Name
- N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
- Synonyms
- BNKY007-PZ01;Pazopanib Impurity 20;2H-indazol-6aMine,2,3-diMethyl.HCl(1:1);N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-;6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole;N-(2-chloropyrimidin-4-yl)-N,2,3-dimethyl-2H-indazol -6-amine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine ISO 9001:2015 REACH
- CBNumber
- CB12526161
- Molecular Formula
- C13H12ClN5
- Formula Weight
- 273.72
- MOL File
- 444731-74-2.mol
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Property
- Melting point:
- >216oC (dec.)
- Boiling point:
- 550.0±35.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.56±0.30(Predicted)
- color
- Pale Orange to Light Brown
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- C380080
- Product name
- N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FC32848
- Product name
- N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine
- Packaging
- 250mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- 095743
- Product name
- N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $439
- Updated
- 2021/12/16
- Product number
- FC32848
- Product name
- N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine
- Packaging
- 500mg
- Price
- $525
- Updated
- 2021/12/16
- Product number
- X3179
- Product name
- N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine
- Packaging
- 5g
- Price
- $728
- Updated
- 2021/12/16
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Chemical Properties,Usage,Production
Uses
N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine (N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine) is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
Application
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine is a valuable organic compound that could be used to synthesize N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, N- (2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, and others.
Synthesis
2,3-dimethyl-6-amino-2H- indazole 5.00g,2,4-Dichloropyrimidine 13.9g and sodium bicarbonate 10.4g were dissolved in 100mL absolute ethanol and heated to 79°C.After refluxing for 4 h, cool to room temperature and filter. The cake was washed well with ethyl acetate, and the filtrate was collected. Concentrate under reduced pressure, remove the solvent, and fully beat with ethyl acetate and filter to give an off-white solid. Recrystallization from methanol gave 7.64 g of product N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine as a white solid, yield: 90.0%.
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Suppliers
- Tel
- 0573-0573-87228088 17772796899
- Fax
- 0573-87228088
- triview@triviewbiochem.com
- Country
- China
- ProdList
- 17
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94838
- Advantage
- 76
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2882
- Advantage
- 65
- Tel
- 021-50460086-9 15921403865
- Fax
- +86-21-50462321
- han_yajun@dctc.daicel.com
- Country
- China
- ProdList
- 6854
- Advantage
- 65
- Tel
- 025-58196018 800028039
- Fax
- 025-83453306
- sales@fartop.net
- Country
- China
- ProdList
- 2231
- Advantage
- 55
- Tel
- 0752-5538396 18927339850
- Fax
- 0752-5319394
- sales1@rafflespt.com
- Country
- China
- ProdList
- 216
- Advantage
- 58
- Tel
- 021-021-60451683 15021268886
- Fax
- +86-21-60451682
- sales@arborchemical.com
- Country
- China
- ProdList
- 922
- Advantage
- 55
- Tel
- +86(0)21 60484900
- Fax
- +86(0)21 60484900
- Country
- China
- ProdList
- 764
- Advantage
- 50
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9906
- Advantage
- 55
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17994
- Advantage
- 56
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4619
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10287
- Advantage
- 55
- Tel
- +86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 10015
- Advantage
- 53
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9798
- Advantage
- 50
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4901
- Advantage
- 55
- Tel
- 025-58362220 15250997978
- Fax
- 025-58362220
- 1511893459@qq.com
- Country
- China
- ProdList
- 7740
- Advantage
- 55
- Tel
- 021-57898186
- Fax
- 021-37699262
- Country
- China
- ProdList
- 449
- Advantage
- 55
- Tel
- 13585175604 13585175604
- Fax
- +86-25-52261140
- sales@chicopharm.com
- Country
- China
- ProdList
- 498
- Advantage
- 65
- Tel
- 0514-80939770 13773367191
- Fax
- 0514-82664689
- yzqyyykj@163.com
- Country
- China
- ProdList
- 228
- Advantage
- 55
- Tel
- 0576-89085261 15867635987
- Fax
- 0576-89085262
- jasonhu09@163.com
- Country
- China
- ProdList
- 442
- Advantage
- 50
- Tel
- 025-87193546 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 9030
- Advantage
- 60
- Tel
- 025-5276156 18936048580
- chemxilang@163.com
- Country
- China
- ProdList
- 4008
- Advantage
- 58
- Tel
- 021-58892003
- info@qiaochem.com
- Country
- China
- ProdList
- 5881
- Advantage
- 65
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9934
- Advantage
- 55
- Tel
- 13675155016
- Fax
- 18912765016
- tongtf110@sina.com
- Country
- China
- ProdList
- 963
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 027-50664929, 13971561712
- Fax
- 027-50664927 / QQ: 3452835437
- hubxys2001@163.com
- Country
- China
- ProdList
- 1437
- Advantage
- 55
- Tel
- 025-52343882 18112933882
- Fax
- 025-52343882
- sales@kldbio.com
- Country
- China
- ProdList
- 2019
- Advantage
- 55
- Tel
- 0711-5919292 15307133740
- Fax
- 0711-5919292
- 3451683016@qq.com
- Country
- China
- ProdList
- 1070
- Advantage
- 58
- Tel
- 025-66113011 18112977050
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16028
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17997
- Advantage
- 58
- Tel
- 021-60345187 13917602471
- Fax
- 021-60345187
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 9908
- Advantage
- 58
- Tel
- 021-58958002 18930822973
- Fax
- 021-58958618
- xiaoyangw@gmail.com
- Country
- China
- ProdList
- 2129
- Advantage
- 58
- Tel
- 0371-67991738 13783628208
- Fax
- QQ 412703949
- carl@alchemist-pharm.com
- Country
- China
- ProdList
- 1877
- Advantage
- 58
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10305
- Advantage
- 58
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4880
- Advantage
- 58
- Tel
- 025-84767922 18936879710
- sales@abydoscientific.com
- Country
- China
- ProdList
- 1029
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55896
- Advantage
- 58
- Tel
- 0755-22202135 13316968096
- 1979313431@qq.com
- Country
- China
- ProdList
- 7789
- Advantage
- 58
- Tel
- 0371-55055611 18137792234
- Fax
- QQ:3002694073
- 3002694073@qq.com
- Country
- China
- ProdList
- 10144
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 28761
- Advantage
- 58
- Tel
- 0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25363
- Advantage
- 58
- Tel
- 571-88938639 +8617705817739
- Fax
- +86-571-88938652,+86-571- 88492614
- info@dycnchem.com
- Country
- CHINA
- ProdList
- 52867
- Advantage
- 58
- Tel
- +8615604608665 15604608665
- dominicguo@gk-bio.com
- Country
- CHINA
- ProdList
- 9427
- Advantage
- 58
- Tel
- +8615056975894
- Fax
- 86-0551-62678551
- shawn@hirisunpharm.com
- Country
- CHINA
- ProdList
- 9923
- Advantage
- 58
- Tel
- 0571-85134551
- Fax
- 008657185134895
- info@afinechem.com
- Country
- CHINA
- ProdList
- 15377
- Advantage
- 58
- Tel
- +8617735180244
- mike_yan@xuanranglobal.com
- Country
- CHINA
- ProdList
- 4022
- Advantage
- 58
- Tel
- 17825480238
- Fax
- QQ 3008233717
- 3008233717@qq.com
- Country
- China
- ProdList
- 9843
- Advantage
- 12
- Tel
- +86-13806087780
- sale@simagchem.com
- Country
- China
- ProdList
- 17367
- Advantage
- 58
View Lastest Price from N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine manufacturers
- Product
- N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine 444731-74-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-23
- Product
- 2H-Indazol-6-amine,N-(2-chloro-4-pyrimidinyl)-2,3-dimethyl- 444731-74-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2018-08-13