1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
Tetrafluoroborate Reaction Main Usage- Product Name
- 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
- CAS No.
- 140681-55-6
- Chemical Name
- 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
- Synonyms
- Selectfluor;Selectfluoro;1-(chloroMethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diiuM;selectfluor fluorinating reagent;1-(ChloroMethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diiuM tetrafluoroborate;selectfluor fluorinating;SELECTFLUOR I;1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane ditetrafluoroborate;Selecetfluor;fluorinating reagent
- CBNumber
- CB1254109
- Molecular Formula
- C7H14B2ClF9N2
- Formula Weight
- 354.26
- MOL File
- 140681-55-6.mol
1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) Property
- Melting point:
- 260 °C(lit.)
- Density
- 1.71 at 20℃
- vapor pressure
- 0.001Pa at 25℃
- storage temp.
- 2-8°C
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated), Water
- form
- Powder
- color
- White
- Water Solubility
- soluble
- Sensitive
- Moisture Sensitive
- Merck
- 14,8425
- BRN
- 5368649
- InChIKey
- ZQGDSZPGKPJABN-UHFFFAOYSA-N
- LogP
- -3.39 at 20℃
- Surface tension
- 73.1mN/m at 1g/L and 19℃
- CAS DataBase Reference
- 140681-55-6(CAS DataBase Reference)
- EPA Substance Registry System
- 1,4-Diazoniabicyclo[2.2.2]octane, 1-(chloromethyl)-4-fluoro-, bis[tetrafluoroborate(1-)] (140681-55-6)
Safety
- Hazard Codes
- Xn,O,F,Xi
- Risk Statements
- 22-36/37/38-41-52/53-43
- Safety Statements
- 26-36/37/39-61-21
- RIDADR
- UN 3088 4.2/PG 2
- WGK Germany
- 2
- Hazard Note
- Oxidising Agent
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29335990
- Toxicity
- LD50 in male rats: 640 mg/kg orally; >2 g/kg dermally (Banks, 1998)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 439479
- Product name
- Selectfluor? fluorinating reagent
- Purity
- >95% in F+ active
- Packaging
- 5g
- Price
- $40.1
- Updated
- 2024/03/01
- Product number
- 439479
- Product name
- Selectfluor? fluorinating reagent
- Purity
- >95% in F+ active
- Packaging
- 25g
- Price
- $119
- Updated
- 2024/03/01
- Product number
- F0358
- Product name
- N-Fluoro-N'-(chloromethyl)triethylenediamine Bis(tetrafluoroborate)
- Purity
- >95.0%(T)
- Packaging
- 5g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- F0358
- Product name
- N-Fluoro-N'-(chloromethyl)triethylenediamine Bis(tetrafluoroborate)
- Purity
- >95.0%(T)
- Packaging
- 25g
- Price
- $94
- Updated
- 2024/03/01
- Product number
- L17003
- Product name
- 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), 98+%
- Packaging
- 5g
- Price
- $55.5
- Updated
- 2024/03/01
1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) Chemical Properties,Usage,Production
Tetrafluoroborate
1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), with the formula C7H14B2ClF9N2, is a selective fluorine reagent which is white crystal at room temperature. It is mainly used asfluorinating agent to make single fluoridation with electronic double bond, silyl enol ether and enol lithium salt and so on. It can be used in the preparation of fluorinated steroid drugs, etc.
Reaction
1. It is one of the most efficient and popular reagents for electrophilic fluorination. The product is also useful as a reagent, or catalyst, for oxidative transformations, coupling reactions and halogenations.
2. Useful for the direct electrophilic fluorination of ketones, ketals and enamides.
3. Ritter-type C-H amination of unactivated sp3.
Main Usage
It is mainly used as fluorinating agent to make single fluoridation with electronic double bond, silyl enol ether and enol lithium salt and so on. It can be used in the preparation of fluorinated steroid drugs, etc.
Description
1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)(Selectfluor) is a white solid (mp 190 °C), stable in air and to moisture. It is a dicationic salt soluble in cold water or dilute hydrochloric acid. However, it decomposes in dilute sodium hydroxide and reacts with cold DMSO (rapidly and exothermally) and with DMF (slowly on heating). It is moderately soluble in acetonitrile but only slightly soluble in lower alcohols and acetone, which makes the former the solvent of choice. Occasionally, reactions in these solvents were accelerated by adding a small amount of water or trifluoroacetic acid. Bulk quantities of Selectfluor should be stored in a cool, dry place and not heated above 80 °C. Fainzil’berg et al. have measured the reduction potentials of Selectfluor and other N-F compounds. With a positive reduction potential, E1/2 ) 0.33 V, Selectfluor is predicted to be a more reactive fluorinating reagent than, e.g., N-fluorobenzenesulfonimide, with E1/2 ) -1.24 V[1].
Chemical Properties
White powder
Uses
Effective electrophilic fluorinating reagent for a wide variety of substrates such as aromatics, alkenes, carbohydrates, etc.
Uses
Mild, versatile fluorinating reagent used in pharmaceutical and agricultural applications.
General Description
This product is a fluorine donor also called Selectfluor and has been enhanced for catalysis.
Toxicology
1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (F-TEDA-BF4) is moderately toxic (male rat oral LD50 640 mg kg?1; female rat 350–500 mg kg?1), and is an irritant to the eye and respiratory system. Always use approved dust mask (or respirator), gloves, and safety glasses when handling the solid. Carry out solubility tests on a sensible scale when seeking alternative solvents (note the problem with DMSO referred to above).
Advantages
As the advantages of non-toxicity, non-corrosion and chemical stability, 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) have been widely used in industry and public life.
References
[1] Rajendra P. Singh, Jean’ne M. Shreeve. “Recent Highlights in Electrophilic Fluorination with 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane Bis(tetrafluoroborate).” ChemInform 35 16 (2004).
1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) manufacturers
- Product
- 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) 140681-55-6
- Price
- US $50.00-30.00/kg
- Min. Order
- 500kg
- Purity
- 99.9
- Supply Ability
- 200tons
- Release date
- 2024-03-07
- Product
- -Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) 140681-55-6
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 99.0%
- Supply Ability
- 20mt
- Release date
- 2023-10-20
- Product
- 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) 140681-55-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09