H2N-PEG2-tBu
- Product Name
- H2N-PEG2-tBu
- CAS No.
- 756525-95-8
- Chemical Name
- H2N-PEG2-tBu
- Synonyms
- tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate;Amino-PEG3-t-butyl ester;Amino-PEG2-t-butyl ester;SDZ-P2-NH2;H2N-PEG2-tBu;NH2-PEG2-C2-Boc;H2N-PEG2-CO-OtBu;Amino-PEG2-COOtBu;NH2-PEG2-C2-COOtBu;NH2-PEG2-CH2CH2COtBu
- CBNumber
- CB12546864
- Molecular Formula
- C11H23NO4
- Formula Weight
- 233.3
- MOL File
- 756525-95-8.mol
H2N-PEG2-tBu Property
- Boiling point:
- 313.7±22.0 °C(Predicted)
- Density
- 1.014±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.74±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3
- InChIKey
- XIVHGTLMLORWEP-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)CCOCCOCCN
Safety
- HS Code
- 2922500090
N-Bromosuccinimide Price
- Product number
- A3325
- Product name
- Amino-PEG2-acid tert-Butyl Ester
- Packaging
- 1G
- Price
- $110
- Updated
- 2025/07/31
- Product number
- A3325
- Product name
- Amino-PEG2-acid tert-Butyl Ester
- Packaging
- 5G
- Price
- $330
- Updated
- 2025/07/31
- Product number
- A577098
- Product name
- 1,1-DimethylethylEster3-[2-(2-Aminoethoxy)Ethoxy]PropanoicAcid
- Packaging
- 500mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- CS-0020723
- Product name
- NH2-PEG2-C2-Boc
- Purity
- 99.62%
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- CS-0020723
- Product name
- NH2-PEG2-C2-Boc
- Purity
- 99.62%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
H2N-PEG2-tBu Chemical Properties,Usage,Production
Description
Amino-PEG2-t-butyl ester is a PEG linker containing an amino group with a t-butyl protected carboxyl group (Boc).The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
3-[2-(2-Aminoethoxy)Ethoxy]Propanoic Acid 1,1-Dimethylethyl Ester is used as reactant in the synthesis of self-localizing ligands that control spatial location of proteins in living cells.
Synthesis
1629676-61-4
756525-95-8
General procedure for the synthesis of tert-butyl 9-amino-4,7-dioxanonanoate from the compound (CAS: 1629676-61-4): 5% Pd/C (JM US 2.14 g) was added to a solution of dibenzylamine 27 (35.0 g, 85 mmol) in methanol (420 mL), and the mixture was placed in an Atlantis reactor and subjected to a hydrogenation reaction at 40 °C and 15 psi hydrogen pressure for the hydrogenation reaction. After 2 h of reaction, the catalyst was removed by filtration and the filtrate was concentrated to yield 18.90 g (96% yield) of amine 7 as a turbid oil, which was used directly in the next step of the reaction without further purification.IR (ATR cells): 2977, 2868, 1727, 1456, 1393, 1367, 1254, 1157, 1113, 847, 755, 589, 564, 547, 536 cm^-1. ^1H NMR (400 MHz, CDCl3): δ = 1.30 (s, 9H), 2.36 (t, J = 6.43 Hz, 2H), 2.71 (t, J = 5.19 Hz, 2H), 3.36 (t, J = 5.19 Hz, 2H), 3.43-3.50 (m, 4H) , 3.57 (t, J = 6.64 Hz, 2H). ^13C NMR (100 MHz, CDCl3): δ = 28.18, 36.36, 41.92, 66.98, 70.32, 70.44, 73.58, 80.52, 170.92. HRMS (ESI): m/z [M + H]^+ Calculated value for C11H24NO4: 234.16998; measured value: 234.17009.
IC 50
PEGs; Alkyl/ether; Non-cleavable Linker
References
[1] Synthesis (Germany), 2014, vol. 46, # 10, p. 1399 - 1406
[2] Patent: WO2016/59622, 2016, A2. Location in patent: Page/Page column 104
[3] Patent: WO2017/46658, 2017, A1. Location in patent: Page/Page column 144
[4] Patent: WO2018/86139, 2018, A1. Location in patent: Page/Page column 152
H2N-PEG2-tBu Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from H2N-PEG2-tBu manufacturers
- Product
- NH2-PEG2-CH2CH2COOtBu 756525-95-8
- Price
- US $22.72/g
- Min. Order
- 10g
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-20
- Product
- tert-butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate 756525-95-8
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-12
- Product
- Amino-PEG2-COOtBu 756525-95-8
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-22