1,14-diamino-3,6,9,12-tetraoxatetradecane

Product Name: 1,14-diamino-3,6,9,12-tetraoxatetradecane
CAS No.: 68960-97-4
Chemical Name: 1,14-diamino-3,6,9,12-tetraoxatetradecane
Synonyms: NH2-PEG4-NH2;3,6,9,12-Tetraoxatetradecane-1,14-diaMine;Amino-PEG4-Amine;mino-PEG4-Amine;Amino-dPEG4-Amino;Amino-PEG4-Amine,NH2-PEG4-NH2;1,14-diamino-3,6,9,12-tetraoxatetradecane;Triethylene Glycol Bis(2-aminoethyl) Ether;2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanamine
CBNumber: CB52469749
Molecular Formula: C10H24N2O4
Formula Weight: 236.31
MOL File: 68960-97-4.mol

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1,14-diamino-3,6,9,12-tetraoxatetradecane Property

Boiling point:: 139°C/0.2mmHg(lit.)
Density: 1.043±0.06 g/cm3(Predicted)
refractive index: 1.4650 to 1.4690
storage temp.: -20°C
solubility: Soluble in Water, DMSO, DCM, DMF
form: clear liquid
pka: 9.04±0.10(Predicted)
color: Colorless to Light yellow
InChI: InChI=1S/C10H24N2O4/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h1-12H2
InChIKey: IFZOPNLVYZYSMQ-UHFFFAOYSA-N
SMILES: C(N)COCCOCCOCCOCCN

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Safety

RIDADR: UN 2735 8/PG III
HazardClass: 8
PackingGroup: III
HS Code: 2942000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JKA12010
Product name: NH2-PEG4-NH2
Packaging: 500MG
Price: $307.8
Updated: 2025/07/31

TCI Chemical

Product number: T3198
Product name: 1,14-Diamino-3,6,9,12-tetraoxatetradecane
Purity: >97.0%(GC)
Packaging: 100mg
Price: $164
Updated: 2025/07/31

TRC

Product number: T306265
Product name: 3,6,9,12-Tetraoxatetradecane-1,14-diamine
Packaging: 1mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T306265
Product name: 3,6,9,12-Tetraoxatetradecane-1,14-diamine
Packaging: 10mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD164979
Product name: 1,14-Diamino-3,6,9,12-tetraoxatetradecane
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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1,14-diamino-3,6,9,12-tetraoxatetradecane Chemical Properties,Usage,Production

Description

Amino-PEG4-Amine is a very useful crosslinker containing two amino groups. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Synthesis

109789-39-1

68960-97-4

The general procedure for the synthesis of 3,6,9,12-tetraoxatetradecane-1,14-diamine from the compound (CAS:109789-39-1) is as follows: 9.1 mmol of methanesulfonyloxy-diethyleneglycol-methanesulfonate (MsO-PEG2-OMs) was dissolved in an appropriate amount of dichloromethane. To this solution, excess ammonia and 2 mmol of tetrabutylammonium bromide were added as a phase transfer catalyst, followed by stirring the reaction at 45 °C for 12 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator and then purified by distillation under reduced pressure to afford the target product 3,6,9,12-tetraoxatetradecane-1,14-diamine (NH2-PEG4-NH2) in a yield of 7.64 mmol and 84%.

IC 50

PEGs

References

[1] Patent: CN107840817, 2018, A. Location in patent: Paragraph 0050; 0052
[2] Inorganic Chemistry, 2015, vol. 54, # 14, p. 6807 - 6820
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2016, vol. 54, # 20, p. 3294 - 3302

1,14-diamino-3,6,9,12-tetraoxatetradecane Preparation Products And Raw materials

Raw materials

Preparation Products

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1,14-diamino-3,6,9,12-tetraoxatetradecane Suppliers

China 115 India 2 Japan 1 United Kingdom 2 United States 10 Global 130

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View Lastest Price from 1,14-diamino-3,6,9,12-tetraoxatetradecane manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: 3,6,9,12-tetraoxatetradecane-1,14-diamine 68960-97-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 68960-97-4
Release date: 2025-09-10

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Amino-PEG4-C2-amine 68960-97-4
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-06

Xian confluore Biological Technology Co., Ltd.

Product: Amino-PEG4-amine 68960-97-4
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-22

68960-97-4, 1,14-diamino-3,6,9,12-tetraoxatetradecaneRelated Search:

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2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanamine

3,6,9,12-Tetraoxatetradecane-1,14-diaMine

Amino-PEG4-Amine

NH2-PEG4-NH2

Amino-dPEG4-Amino

1,14-diamino-3,6,9,12-tetraoxatetradecane

Amino-PEG4-Amine,NH2-PEG4-NH2

mino-PEG4-Amine

Triethylene Glycol Bis(2-aminoethyl) Ether

68960-97-4

PROTAC LINKER

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