5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester

Uses

Product Name: 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester
CAS No.: 101187-40-0
Chemical Name: 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester
Synonyms: 13-amino;NH2-PEG3-NHBOC;NHBoc-PEG4-NH2;BOC-NH-PEG3-NH2;NHBoc-PEG3-amine;Amino-PEG4-NHBoc;PROTAC Linker 15;N-Boc-3,6,9-triox;BOC-N-AMIDO-PEG3-NH2;Boc-NH-PEG3-CH2CH2NH2
CBNumber: CB72470859
Molecular Formula: C13H28N2O5
Formula Weight: 292.37
MOL File: 101187-40-0.mol

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5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester Property

Boiling point:: 405.7±35.0 °C(Predicted)
Density: 1.050
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Soluble in Water, DMSO, DCM, DMF
form: clear liquid to cloudy liquid
pka: 12.23±0.46(Predicted)
color: Colorless to Light yellow to Light orange
InChI: InChI=1S/C13H28N2O5/c1-13(2,3)20-12(16)15-5-7-18-9-11-19-10-8-17-6-4-14/h4-11,14H2,1-3H3,(H,15,16)
InChIKey: CUPBLDPRUBNAIE-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCOCCOCCOCCN

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 07185
Product name: N-Boc-1,11-diamino-3,6,9-trioxaundecane oxalate salt
Purity: purum, ≥97.0% (TLC)
Packaging: 100mg
Price: $261
Updated: 2023/06/20

TCI Chemical

Product number: B6080
Product name: Boc-Amino-PEG3-Amine
Packaging: 250MG
Price: $109
Updated: 2025/07/31

TCI Chemical

Product number: B6080
Product name: Boc-Amino-PEG3-Amine
Packaging: 1G
Price: $308
Updated: 2025/07/31

TRC

Product number: B659028
Product name: N-Boc-1,11-diamino-3,6,9-trioxaundecane
Packaging: 100mg
Price: $90
Updated: 2021/12/16

TRC

Product number: B659028
Product name: N-Boc-1,11-diamino-3,6,9-trioxaundecane
Packaging: 500mg
Price: $350
Updated: 2021/12/16

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5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester Chemical Properties,Usage,Production

Uses

N-Boc-1,11-Diamino-3,6,9-trioxaundecane is a useful research chemical.

Description

t-Boc-N-Amido-PEG3-amine is a PEG linker with an amino group and Boc-protected amino. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to free the amine.

Chemical Properties

Colorless viscous liquid

Synthesis

929-75-9

24424-99-5

101187-40-0

General procedure: 3,6,9-Trioxaundecane-1,11-diamine (1 eq.) was dissolved in dichloromethane (DCM, 10 mL/mmol), and di-tert-butyl dicarbonate (Boc2O, 0.15 eq.) was slowly added at 0 °C. The reaction mixture was stirred at 0°C for 5 hours, then brought to room temperature and continued stirring for 18 hours. Upon completion of the reaction, the organic phase was washed several times with water to remove unreacted 3,6,9-trioxaundecane-1,11-diamine. The organic phase was dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to quantitatively yield the Boc-protected product (tert-butyl 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate. 1H NMR (300 MHz, CDCl3) data for product 11a: δ 1.45 (s, 9H), 1.80 (br m, 2H, NH2), 3.25 (m, 2H), 3.38 (m, 2H), 3.50-3.70 (m, 8H), 5.10 (br s, 1H, NHCO2). 1H NMR (300 MHz, CDCl3) data for product 11b: δ 1.42 (s, 9H), 1.75 (br m, 2H, NH2), 2.84 (t, 2H, J = 5.3 Hz), 3.29 (m, 2H), 3.51 (m, 4H), 3.58 (sharp m, 8H), 5.30 (br s, 1H, NHCO2). NHCO2).

References

[1] Tetrahedron, 2012, vol. 68, # 52, p. 10818 - 10826
[2] Journal of the American Chemical Society, 2001, vol. 123, # 37, p. 8914 - 8922
[3] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 3, p. 625 - 637
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 6, p. 853 - 856
[5] Journal of the American Chemical Society, 2015, vol. 137, # 28, p. 9108 - 9116

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester Suppliers

Americas 1 China 176 Europe 1 India 4 Japan 2 United Kingdom 2 United States 15 Global 201

Nanjing Junnahe Biopharmaceutical Co., Ltd

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View Lastest Price from 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester manufacturers

LAURENT

Product: BocNH-PEG3-CH2CH2NH2 101187-40-0
Price: US $23.52/g
Min. Order: 10g
Purity: 98%
Supply Ability: 500kg
Release date: 2025-11-15

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: tert-butyl (2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate 101187-40-0
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-12

Henan Fengda Chemical Co., Ltd

Product: 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester 101187-40-0
Price: US $6.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

101187-40-0, 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl esterRelated Search:

N-(4-AMINOBUTYL)-N-METHYL CARBAMIC ACID TERT-BUTYL ESTER-HCl 2-[2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL 1,14-diamino-3,6,9,12-tetraoxatetradecane alpha, oMega-Dipropionic acid hexaethylene glycol 2-(2-Methoxyethoxy)ethanamine H2N-PEG8-tBu FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID Amino-PEG4-acid Biotin-PEG3-N3 O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- 3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL HO-PEG10-tBu N3-PEG3-tBu DODECAETHYLENE GLYCOL MONOMETHYL ETHER α,ω-dipropionic acid tetraethylene glycol 2,5,8,11,14,17,20-Heptaoxadocosan-22-amine

t-Boc-N-Amido-PEG3-Amine

Boc-N-Amido-PEG3-Amine

tert-butyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate

BOC-NH-PEG3-NH2

tert-Butyl (2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate

N-Boc-1,11-diamino-3,6,9-trioxaundecane≥ 98% (GC)

tert-Boc-N-amido-PEG3-amine

N-Boc-2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}

t-BocNH-PEG3-CH2CH2NH2

NHBoc-PEG3-amine

N-Boc-1,11-diamino-3,6,9-trioxaundecane

1-Boc-amino-11-bromo-3.6.9-trioxadecane

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester

13-Amino-5,8,11-trioxa-2-azatridecanoic acid 1,1-dimethylethyl ester

5,8,11-Trioxa-2-azatridecanoic acid, 13-aMino-, 1,1-diMethylethyl ester

Boc-NH-PEG3-CH2CH2NH2

Amino-PEG4-NHBoc

terr-butyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate

BOC-N-AMIDO-PEG3-NH2

N-Boc-2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethylamine, 98%

NH2-PEG3-NHBOC

NHBoc-PEG4-NH2

N-Boc-2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanamine

13-AMINO-5,8,11-TRIOXA-2-AZATRIDECANOIC ACID TERT-BUTYL ESTER

[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]carbamic Acid tert-Butyl Ester

N-(tert-Butoxycarbonyl)-3,6,9-trioxa-1,11-undecanediamine

N-Boc-3,6,9-triox

PROTAC Linker 15

11-Trioxa-2-azatridecanoic

13-amino

N-Boc-2-{2-[2-(2-amino-ethoxy)-et

（2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate

ert-butylN-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate

t-Boc-Amido-PEG4-Amine

BocNH-PEG3-CH2CH2NH2/5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, 1,1-dimethylethyl ester

1-Boc-amine-11-amino-3,6,9-trioxaundecane

5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethyle

<i>N</i>-Boc-1,11-diamino-3,6,9-trioxaundecane oxalate salt

101187-40-0

1011187-40-0

C13H28N2O5

ADCs Linkers

peg