α,ω-dipropionic acid tetraethylene glycol
- Product Name
- α,ω-dipropionic acid tetraethylene glycol
- CAS No.
- 439114-13-3
- Chemical Name
- α,ω-dipropionic acid tetraethylene glycol
- Synonyms
- 4,7,10,13,16-Pentaoxanonadecanedioic Acid;Di-Acid-PEG5;Bis-PEG6-acid;Bis-PEG5-COOH;COOH-PEG4-COOH;COOH-PEG5-COOH;Acid-PEG4-Acid;Bis-dPEG??-acid;PROTAC Linker 36;Bis-PEG4-CH2CH2COOH
- CBNumber
- CB52501436
- Molecular Formula
- C14H26O9
- Formula Weight
- 338.35
- MOL File
- 439114-13-3.mol
α,ω-dipropionic acid tetraethylene glycol Property
- Boiling point:
- 513.6±50.0 °C(Predicted)
- Density
- 1.205±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.97±0.10(Predicted)
- form
- Solid
- color
- White to off-white
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P3042
- Product name
- Bis-PEG5-acid
- Purity
- min. 95.0 %
- Packaging
- 250MG
- Price
- $104
- Updated
- 2025/07/31
- Product number
- P3042
- Product name
- Bis-PEG5-acid
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $261
- Updated
- 2025/07/31
- Product number
- P227300
- Product name
- 4,7,10,13,16-PentaoxanonadecanedioicAcid
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- BP-20412
- Product name
- Bis-PEG5-acid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 0453AP
- Product name
- HOOC-PEG4-COOH
- Packaging
- 250mg
- Price
- $132
- Updated
- 2021/12/16
α,ω-dipropionic acid tetraethylene glycol Chemical Properties,Usage,Production
Description
Bis-PEG5-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
A dicarboxylic acid used in the preparation of potent dimeric inhibitors of the PSD-95-NMDA receptor interaction.
Uses
As a dicarboxylic acid, 4,7,10,13,16-Pentaoxanonadecanedioic Acid can be used in the preparation of potent dimeric inhibitors of the PSD-95-NMDA receptor interaction.
Synthesis
439114-12-2
439114-13-3
The general procedure for the synthesis of 4,7,10,13,16-pentaoxa-nineteenthane-1,19-dioic acid from di-tert-butyl 4,7,10,13,16-pentaoxa-nineteenthane-1,19-dioic acid is as follows: tert-butyl 3-{2-[2-[2-(2-{2-[2-(2-tert-butyloxycarbonyl-ethoxy)ethoxy]ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionate (6 g, 18.6 mmol) was dissolved in anisole (20 ml) and cooled in an ice bath. Subsequently, trifluoroacetic acid (65 g) was added slowly. The reaction mixture was stirred at room temperature for 3 hours and the volatiles were removed by distillation under reduced pressure. The residue was extracted by partitioning between ethyl acetate (50 ml) and 5% sodium bicarbonate solution. The aqueous layer was acidified with 1N HCl to pH<2, then saturated with NaCl and extracted with ethyl acetate (3 x 50 ml). The organic layers were combined, washed with saturated brine and dried with anhydrous sodium sulfate. Finally, the solvent was removed by distillation under reduced pressure to afford the target product 4,7,10,13,16-pentaoxadecane-1,19-dioic acid as a colorless liquid, which solidified to a white solid after refrigeration (3.8 g, 82% yield).
IC 50
PEGs
References
[1] Patent: US2006/205670, 2006, A1. Location in patent: Page/Page column 103
[2] Patent: US2008/166364, 2008, A1. Location in patent: Page/Page column 104-105
α,ω-dipropionic acid tetraethylene glycol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from α,ω-dipropionic acid tetraethylene glycol manufacturers
- Product
- 4,7,10,13,16-Pentaoxanonadecanedioic acid 439114-13-3
- Price
- US $193.00-697.00/g
- Min. Order
- 5g
- Purity
- 0.97
- Supply Ability
- 25kg
- Release date
- 2023-12-22
- Product
- Bis-PEG5-acid 439114-13-3
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-23