N3-PEG3-tBu
- Product Name
- N3-PEG3-tBu
- CAS No.
- 252881-73-5
- Chemical Name
- N3-PEG3-tBu
- Synonyms
- N3-PEG3-tBu;N3-PEG3-TBA;Azido-PEG3-COOtBu;N3-PEG3-CH2CH2-Boc;N?-PEG?-CH?CH?COOtBu;N3-PEG3-CH2CH2COOtBu;Azido-PEG3-tBu Ester;Azido-PEG3-CH2CH2COOtBu;N3-?PEG3-?t-?butyl ester;N3-PEG3-CH2CH2COOt<
- CBNumber
- CB12546985
- Molecular Formula
- C13H25N3O5
- Formula Weight
- 303.3547
- MOL File
- 252881-73-5.mol
N3-PEG3-tBu Property
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A925065
- Product name
- Azido-PEG3-t-butylEster
- Packaging
- 1g
- Price
- $315
- Updated
- 2021/12/16
- Product number
- BP-20637
- Product name
- Azido-PEG3-t-butylester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- BP-20637
- Product name
- Azido-PEG3-t-butylester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- BP-20637
- Product name
- Azido-PEG3-t-butylester
- Purity
- 98%
- Packaging
- 1g
- Price
- $440
- Updated
- 2021/12/16
- Product number
- 280701
- Product name
- N3-PEG3-tBu
- Packaging
- 1g
- Price
- $449
- Updated
- 2021/12/16
N3-PEG3-tBu Chemical Properties,Usage,Production
Description
Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Azido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides.
Biological Activity
N3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| PEGs
| Alkyl/ether
| Cleavable
|
N3-PEG3-tBu Preparation Products And Raw materials
Raw materials
Preparation Products
N3-PEG3-tBu Suppliers
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View Lastest Price from N3-PEG3-tBu manufacturers
- Product
- azido-PEG3-t-Butyl ester 252881-73-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23