N3-PEG3-tBu
- Product Name
- N3-PEG3-tBu
- CAS No.
- 252881-73-5
- Chemical Name
- N3-PEG3-tBu
- Synonyms
- N3-PEG3-tBu;Azido-PEG3-COOtBu;N3-PEG3-CH2CH2-Boc;N?-PEG?-CH?CH?COOtBu;N3-PEG3-CH2CH2COOtBu;Azido-PEG3-tBu Ester;Azido-PEG3-CH2CH2COOtBu;N3-?PEG3-?t-?butyl ester;N3-(CH2CH2O)3-CH2CH2COOt-Bu;tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate
- CBNumber
- CB12546985
- Molecular Formula
- C13H25N3O5
- Formula Weight
- 303.3547
- MOL File
- 252881-73-5.mol
N-Bromosuccinimide Price
- Product number
- A925065
- Product name
- Azido-PEG3-t-butylEster
- Packaging
- 1g
- Price
- $315
- Updated
- 2021/12/16
- Product number
- BP-20637
- Product name
- Azido-PEG3-t-butylester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- BP-20637
- Product name
- Azido-PEG3-t-butylester
- Purity
- 98%
- Packaging
- 1g
- Price
- $440
- Updated
- 2021/12/16
- Product number
- 280701
- Product name
- N3-PEG3-tBu
- Packaging
- 1g
- Price
- $449
- Updated
- 2021/12/16
- Product number
- AMTGC716
- Product name
- tert-butyl3-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}propanoate
- Packaging
- 5g
- Price
- $660
- Updated
- 2021/12/16
N3-PEG3-tBu Chemical Properties,Usage,Production
Description
Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Azido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides.
Biological Activity
N3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| PEGs
| Alkyl/ether
| Cleavable
|
N3-PEG3-tBu Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N3-PEG3-tBu manufacturers
- Product
- azido-PEG3-t-Butyl ester 252881-73-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23